Dependence of plasminogen activator inhibitor-1 level on -675 4G/5G polymorphism in PAI-1 gene in patients with traumatic brain injury
The purpose. To study relationship between plasminogen activator inhibitor-1 (PAI-1) level in plasma and -675 4G/5G polymorphism in the PAI-1 gene in patients with traumatic brain injury (TBI) in dynamics of treatment.Materials and methods. The state of hemostasis in 200 patients with TBI...
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| Format: | Article |
| Language: | English |
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Romodanov Neurosurgery Institute
2014-12-01
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| Series: | Ukrainian Neurosurgical Journal |
| Online Access: | https://theunj.org/article/view/46604 |
| _version_ | 1797348269105348608 |
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| author | Oleksandr Potapov Jr Oleksii Kmyta |
| author_facet | Oleksandr Potapov Jr Oleksii Kmyta |
| author_sort | Oleksandr Potapov Jr |
| collection | DOAJ |
| description |
The purpose. To study relationship between plasminogen activator inhibitor-1 (PAI-1) level in plasma and -675 4G/5G polymorphism in the PAI-1 gene in patients with traumatic brain injury (TBI) in dynamics of treatment.Materials and methods. The state of hemostasis in 200 patients with TBI was analyzed by means of studying relationship between PAI-1 level in plasma and -675 4G/5G polymorphism in the PAI-1 gene.Results. Correlation between PAI-1 level increasing and 4G/4G and 4G/5G genotype in patients was shown. PAI-1 level increasing in dynamics of treatment was found in patients with 4G/4G and 4G/5G genotypes.Conclusions. The relationship between -675 4G/5G polymorphism in the PAI-1 gene and PAI-1 level in plasma in patients with TBI was proved. |
| first_indexed | 2024-03-08T12:03:20Z |
| format | Article |
| id | doaj.art-1d064d149c914bef86284641e3588bf3 |
| institution | Directory Open Access Journal |
| issn | 2663-9084 2663-9092 |
| language | English |
| last_indexed | 2024-03-08T12:03:20Z |
| publishDate | 2014-12-01 |
| publisher | Romodanov Neurosurgery Institute |
| record_format | Article |
| series | Ukrainian Neurosurgical Journal |
| spelling | doaj.art-1d064d149c914bef86284641e3588bf32024-01-23T13:31:38ZengRomodanov Neurosurgery InstituteUkrainian Neurosurgical Journal2663-90842663-90922014-12-014616410.25305/unj.46604Dependence of plasminogen activator inhibitor-1 level on -675 4G/5G polymorphism in PAI-1 gene in patients with traumatic brain injuryOleksandr Potapov Jr0Oleksii Kmyta1Department of Neurosurgery and Neurology, Medical Institute of Sumy State University, Sumy, UkraineDepartment of Neurosurgery and Neurology, Medical Institute of Sumy State University, Sumy, Ukraine The purpose. To study relationship between plasminogen activator inhibitor-1 (PAI-1) level in plasma and -675 4G/5G polymorphism in the PAI-1 gene in patients with traumatic brain injury (TBI) in dynamics of treatment.Materials and methods. The state of hemostasis in 200 patients with TBI was analyzed by means of studying relationship between PAI-1 level in plasma and -675 4G/5G polymorphism in the PAI-1 gene.Results. Correlation between PAI-1 level increasing and 4G/4G and 4G/5G genotype in patients was shown. PAI-1 level increasing in dynamics of treatment was found in patients with 4G/4G and 4G/5G genotypes.Conclusions. The relationship between -675 4G/5G polymorphism in the PAI-1 gene and PAI-1 level in plasma in patients with TBI was proved.https://theunj.org/article/view/46604 |
| spellingShingle | Oleksandr Potapov Jr Oleksii Kmyta Dependence of plasminogen activator inhibitor-1 level on -675 4G/5G polymorphism in PAI-1 gene in patients with traumatic brain injury Ukrainian Neurosurgical Journal |
| title | Dependence of plasminogen activator inhibitor-1 level on -675 4G/5G polymorphism in PAI-1 gene in patients with traumatic brain injury |
| title_full | Dependence of plasminogen activator inhibitor-1 level on -675 4G/5G polymorphism in PAI-1 gene in patients with traumatic brain injury |
| title_fullStr | Dependence of plasminogen activator inhibitor-1 level on -675 4G/5G polymorphism in PAI-1 gene in patients with traumatic brain injury |
| title_full_unstemmed | Dependence of plasminogen activator inhibitor-1 level on -675 4G/5G polymorphism in PAI-1 gene in patients with traumatic brain injury |
| title_short | Dependence of plasminogen activator inhibitor-1 level on -675 4G/5G polymorphism in PAI-1 gene in patients with traumatic brain injury |
| title_sort | dependence of plasminogen activator inhibitor 1 level on 675 4g 5g polymorphism in pai 1 gene in patients with traumatic brain injury |
| url | https://theunj.org/article/view/46604 |
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