A meta-analysis of active smoking and risk of meningioma
Introduction Cigarette smoking has been hypothesized to be a risk factor for meningioma. However, the results of studies exploring the relationship between smoking exposure and the occurrence of meningioma are inconsistent. Methods A search of PubMed, Medline, Embase, and Science Direct (up to June...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
European Publishing
2021-05-01
|
| Series: | Tobacco Induced Diseases |
| Subjects: | |
| Online Access: | http://www.tobaccoinduceddiseases.org/A-meta-analysis-of-active-smoking-and-risk-of-meningioma,133704,0,2.html |
| _version_ | 1818792234212917248 |
|---|---|
| author | Hong Chao<sup>+</sup> Yu Cheng<sup>+</sup> Jie Shan Hai-Feng Xue Wei-Lan Xu Hong-Jie Li Meng E |
| author_facet | Hong Chao<sup>+</sup> Yu Cheng<sup>+</sup> Jie Shan Hai-Feng Xue Wei-Lan Xu Hong-Jie Li Meng E |
| author_sort | Hong Chao<sup>+</sup> |
| collection | DOAJ |
| description | Introduction
Cigarette smoking has been hypothesized to be a risk factor for
meningioma. However, the results of studies exploring the relationship between
smoking exposure and the occurrence of meningioma are inconsistent.
Methods
A search of PubMed, Medline, Embase, and Science Direct (up to June
2020) databases was performed. Two authors independently extracted the data.
The Newcastle–Ottawa Scale was employed for judging the quality of articles. A
random-effects model was utilized for meta-analysis. Association analysis between
smoking and meningioma was based on the adjusted RR and the 95% CI, as
reported by eligible studies. Subgroup and sensitivity analyses were performed and
publication bias was assessed. Subgroup analysis was conducted by geographical
region, study design, sex, study quality, and adjustments of RR score. Begg’s and
Egger’s tests were employed for detecting publication bias.
Results
Twelve articles, including 2 cohort studies and 10 case–control studies,
and a total of 1210167 participants were identified. The pooled relative risk (RR)
with 95% confidence interval (95% CI) implied that smoking was not associated
with increased risk of meningioma in men and women combined (RR=1.09; 95%
CI: 0.90–1.33). From the sex-stratified subgroup analysis, the risk of meningioma
was significant in men (RR=1.42; 95% CI: 1.16–1.74). Risk of meningioma in
women did not remain significant (RR=0.92; 95% CI: 0.73–1.16). There was
a high heterogeneity in the results (I2=58.4%, p=0.002). Sensitivity analyses
showed stable results and there was no evidence of publication bias.
Conclusions
Cigarette smoking is not associated with a significantly increased risk
of meningioma in the whole population, but there is a positive association in men
but not in women. |
| first_indexed | 2024-12-18T15:24:00Z |
| format | Article |
| id | doaj.art-1d0c20014b7a46d09b0863f65f89c690 |
| institution | Directory Open Access Journal |
| issn | 1617-9625 |
| language | English |
| last_indexed | 2024-12-18T15:24:00Z |
| publishDate | 2021-05-01 |
| publisher | European Publishing |
| record_format | Article |
| series | Tobacco Induced Diseases |
| spelling | doaj.art-1d0c20014b7a46d09b0863f65f89c6902022-12-21T21:03:19ZengEuropean PublishingTobacco Induced Diseases1617-96252021-05-0119May1810.18332/tid/133704133704A meta-analysis of active smoking and risk of meningiomaHong Chao<sup>+</sup>0Yu Cheng<sup>+</sup>1Jie Shan2Hai-Feng Xue3Wei-Lan Xu4Hong-Jie Li5Meng E6Public Health College, Qiqihar Medical University, Qiqihar, ChinaPublic Health College, Qiqihar Medical University, Qiqihar, ChinaThe Third Affiliated Hospital, Qiqihar Medical University, Qiqihar, ChinaPublic Health College, Qiqihar Medical University, Qiqihar, ChinaInternational Education College, Qiqihar Medical University, Qiqihar, ChinaPublic Health College, Qiqihar Medical University, Qiqihar, ChinaYangzhou Center for Disease Control and Prevention, Yangzhou, ChinaIntroduction Cigarette smoking has been hypothesized to be a risk factor for meningioma. However, the results of studies exploring the relationship between smoking exposure and the occurrence of meningioma are inconsistent. Methods A search of PubMed, Medline, Embase, and Science Direct (up to June 2020) databases was performed. Two authors independently extracted the data. The Newcastle–Ottawa Scale was employed for judging the quality of articles. A random-effects model was utilized for meta-analysis. Association analysis between smoking and meningioma was based on the adjusted RR and the 95% CI, as reported by eligible studies. Subgroup and sensitivity analyses were performed and publication bias was assessed. Subgroup analysis was conducted by geographical region, study design, sex, study quality, and adjustments of RR score. Begg’s and Egger’s tests were employed for detecting publication bias. Results Twelve articles, including 2 cohort studies and 10 case–control studies, and a total of 1210167 participants were identified. The pooled relative risk (RR) with 95% confidence interval (95% CI) implied that smoking was not associated with increased risk of meningioma in men and women combined (RR=1.09; 95% CI: 0.90–1.33). From the sex-stratified subgroup analysis, the risk of meningioma was significant in men (RR=1.42; 95% CI: 1.16–1.74). Risk of meningioma in women did not remain significant (RR=0.92; 95% CI: 0.73–1.16). There was a high heterogeneity in the results (I2=58.4%, p=0.002). Sensitivity analyses showed stable results and there was no evidence of publication bias. Conclusions Cigarette smoking is not associated with a significantly increased risk of meningioma in the whole population, but there is a positive association in men but not in women.http://www.tobaccoinduceddiseases.org/A-meta-analysis-of-active-smoking-and-risk-of-meningioma,133704,0,2.htmlmeningiomasmokingmeta-analysis |
| spellingShingle | Hong Chao<sup>+</sup> Yu Cheng<sup>+</sup> Jie Shan Hai-Feng Xue Wei-Lan Xu Hong-Jie Li Meng E A meta-analysis of active smoking and risk of meningioma Tobacco Induced Diseases meningioma smoking meta-analysis |
| title | A meta-analysis of active smoking and risk of meningioma |
| title_full | A meta-analysis of active smoking and risk of meningioma |
| title_fullStr | A meta-analysis of active smoking and risk of meningioma |
| title_full_unstemmed | A meta-analysis of active smoking and risk of meningioma |
| title_short | A meta-analysis of active smoking and risk of meningioma |
| title_sort | meta analysis of active smoking and risk of meningioma |
| topic | meningioma smoking meta-analysis |
| url | http://www.tobaccoinduceddiseases.org/A-meta-analysis-of-active-smoking-and-risk-of-meningioma,133704,0,2.html |
| work_keys_str_mv | AT hongchaosupsup ametaanalysisofactivesmokingandriskofmeningioma AT yuchengsupsup ametaanalysisofactivesmokingandriskofmeningioma AT jieshan ametaanalysisofactivesmokingandriskofmeningioma AT haifengxue ametaanalysisofactivesmokingandriskofmeningioma AT weilanxu ametaanalysisofactivesmokingandriskofmeningioma AT hongjieli ametaanalysisofactivesmokingandriskofmeningioma AT menge ametaanalysisofactivesmokingandriskofmeningioma AT hongchaosupsup metaanalysisofactivesmokingandriskofmeningioma AT yuchengsupsup metaanalysisofactivesmokingandriskofmeningioma AT jieshan metaanalysisofactivesmokingandriskofmeningioma AT haifengxue metaanalysisofactivesmokingandriskofmeningioma AT weilanxu metaanalysisofactivesmokingandriskofmeningioma AT hongjieli metaanalysisofactivesmokingandriskofmeningioma AT menge metaanalysisofactivesmokingandriskofmeningioma |