ARID1A loss derepresses a group of human endogenous retrovirus-H loci to modulate BRD4-dependent transcription

ARID1A loss derepresses a group of human endogenous retrovirus-H loci to modulate BRD4-dependent transcription

Here the authors show mutation of the BAF chromatin remodeler subunit ARID1A results in an ARID1B-dependent upregulation of HERVH, an ERV required for the pluripotency regulatory network. These HERVH RNAs can partition into BRD4 foci, affecting BRD4-dependent transcription. Suppression of HERVH in c...

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Bibliographic Details
Main Authors: Chunhong Yu, Xiaoyun Lei, Fang Chen, Song Mao, Lu Lv, Honglu Liu, Xueying Hu, Runhan Wang, Licong Shen, Na Zhang, Yang Meng, Yunfan Shen, Jiale Chen, Pishun Li, Shi Huang, Changwei Lin, Zhuohua Zhang, Kai Yuan
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-31197-4

Internet

https://doi.org/10.1038/s41467-022-31197-4

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