Evaluation of immunomodulatory activity of " Shirishavaleha"-An Ayurvedic compound formulation in albino rats
The immunomodulatory activity of Shirishavaleha prepared from two different parts of Shirisha (Albizia lebbeck Benth), i.e., Twak (Bark) and Sara (Heartwood) as main ingredients was evaluated for humoral antibody formation and cell-mediated immunity in established experimental models. The study used...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2011-01-01
|
| Series: | Journal of Ayurveda and Integrative Medicine |
| Subjects: | |
| Online Access: | http://www.jaim.in/article.asp?issn=0975-9476;year=2011;volume=2;issue=4;spage=192;epage=196;aulast=Yadav |
| _version_ | 1818132558743863296 |
|---|---|
| author | Shyamlal Singh Yadav Galib P K Prajapati B K Ashok B Ravishankar |
| author_facet | Shyamlal Singh Yadav Galib P K Prajapati B K Ashok B Ravishankar |
| author_sort | Shyamlal Singh Yadav |
| collection | DOAJ |
| description | The immunomodulatory activity of Shirishavaleha prepared from two different parts of Shirisha (Albizia lebbeck Benth), i.e., Twak (Bark) and Sara (Heartwood) as main ingredients was evaluated for humoral antibody formation and cell-mediated immunity in established experimental models. The study used Wistar rats of either sex weighing 200 ± 40 g, while the test drug was administered orally at a dose of 1.8 g/kg. Hemagglutination titer and body weight were recorded to assess effects on humoral immunity; immunological paw edema was assessed for cell-mediated immunity. Shirishavaleha prepared from heartwood shows significant enhancement in antibody formation, attenuation of body weight changes, and suppression of immunological paw edema, while Shirishavaleha prepared from bark shows weak immunomodulatory activity. The study therefore concludes that Shirishavaleha prepared from heartwood has significant immunomodulatory activity. |
| first_indexed | 2024-12-11T08:38:45Z |
| format | Article |
| id | doaj.art-1d0e86d4a5874fa89ba2ab39a12b7cc0 |
| institution | Directory Open Access Journal |
| issn | 0975-9476 |
| language | English |
| last_indexed | 2024-12-11T08:38:45Z |
| publishDate | 2011-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Ayurveda and Integrative Medicine |
| spelling | doaj.art-1d0e86d4a5874fa89ba2ab39a12b7cc02022-12-22T01:14:18ZengElsevierJournal of Ayurveda and Integrative Medicine0975-94762011-01-012419219610.4103/0975-9476.90775Evaluation of immunomodulatory activity of " Shirishavaleha"-An Ayurvedic compound formulation in albino ratsShyamlal Singh YadavGalibP K PrajapatiB K AshokB RavishankarThe immunomodulatory activity of Shirishavaleha prepared from two different parts of Shirisha (Albizia lebbeck Benth), i.e., Twak (Bark) and Sara (Heartwood) as main ingredients was evaluated for humoral antibody formation and cell-mediated immunity in established experimental models. The study used Wistar rats of either sex weighing 200 ± 40 g, while the test drug was administered orally at a dose of 1.8 g/kg. Hemagglutination titer and body weight were recorded to assess effects on humoral immunity; immunological paw edema was assessed for cell-mediated immunity. Shirishavaleha prepared from heartwood shows significant enhancement in antibody formation, attenuation of body weight changes, and suppression of immunological paw edema, while Shirishavaleha prepared from bark shows weak immunomodulatory activity. The study therefore concludes that Shirishavaleha prepared from heartwood has significant immunomodulatory activity.http://www.jaim.in/article.asp?issn=0975-9476;year=2011;volume=2;issue=4;spage=192;epage=196;aulast=YadavAlbizia lebbeckavaleha hemagglutination titerimmunomodulatory activity |
| spellingShingle | Shyamlal Singh Yadav Galib P K Prajapati B K Ashok B Ravishankar Evaluation of immunomodulatory activity of " Shirishavaleha"-An Ayurvedic compound formulation in albino rats Journal of Ayurveda and Integrative Medicine Albizia lebbeck avaleha hemagglutination titer immunomodulatory activity |
| title | Evaluation of immunomodulatory activity of " Shirishavaleha"-An Ayurvedic compound formulation in albino rats |
| title_full | Evaluation of immunomodulatory activity of " Shirishavaleha"-An Ayurvedic compound formulation in albino rats |
| title_fullStr | Evaluation of immunomodulatory activity of " Shirishavaleha"-An Ayurvedic compound formulation in albino rats |
| title_full_unstemmed | Evaluation of immunomodulatory activity of " Shirishavaleha"-An Ayurvedic compound formulation in albino rats |
| title_short | Evaluation of immunomodulatory activity of " Shirishavaleha"-An Ayurvedic compound formulation in albino rats |
| title_sort | evaluation of immunomodulatory activity of shirishavaleha an ayurvedic compound formulation in albino rats |
| topic | Albizia lebbeck avaleha hemagglutination titer immunomodulatory activity |
| url | http://www.jaim.in/article.asp?issn=0975-9476;year=2011;volume=2;issue=4;spage=192;epage=196;aulast=Yadav |
| work_keys_str_mv | AT shyamlalsinghyadav evaluationofimmunomodulatoryactivityofshirishavalehaanayurvediccompoundformulationinalbinorats AT galib evaluationofimmunomodulatoryactivityofshirishavalehaanayurvediccompoundformulationinalbinorats AT pkprajapati evaluationofimmunomodulatoryactivityofshirishavalehaanayurvediccompoundformulationinalbinorats AT bkashok evaluationofimmunomodulatoryactivityofshirishavalehaanayurvediccompoundformulationinalbinorats AT bravishankar evaluationofimmunomodulatoryactivityofshirishavalehaanayurvediccompoundformulationinalbinorats |