Developmental regulation of spatio-temporal patterns of cortical circuit activation
Neural circuits are refined in an experience-dependent manner during early postnatal development. How development modulates the spatio-temporal propagation of activity through cortical circuits is poorly understood. Here we use voltage sensitive dye imaging (VSD) to show that there are significant c...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-01-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncel.2012.00065/full |
| _version_ | 1811256069225185280 |
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| author | Trevor Charles Griffen Trevor Charles Griffen Trevor Charles Griffen Lang eWang Alfredo eFontanini Arianna eMaffei |
| author_facet | Trevor Charles Griffen Trevor Charles Griffen Trevor Charles Griffen Lang eWang Alfredo eFontanini Arianna eMaffei |
| author_sort | Trevor Charles Griffen |
| collection | DOAJ |
| description | Neural circuits are refined in an experience-dependent manner during early postnatal development. How development modulates the spatio-temporal propagation of activity through cortical circuits is poorly understood. Here we use voltage sensitive dye imaging (VSD) to show that there are significant changes in the spatio-temporal patterns of intracortical signals in primary visual cortex from postnatal day 13 (P13), eye opening, to P28, the peak of the critical period for rodent visual cortical plasticity. Upon direct stimulation of layer 4 (L4), activity spreads to L2/3 and to L5 at all ages. However, while from eye opening to the peak of the critical period, the amplitude and persistence of the voltage signal decrease, peak activation is reached more quickly and the interlaminar gain increases with age. The lateral spread of activation within layers remains unchanged throughout the time window under analysis. These developmental changes in spatio-temporal patterns of intracortical circuit activation are mediated by differences in the contributions of excitatory and inhibitory synaptic components. Our results demonstrate that after eye opening the circuit in primary visual cortex is refined through a progression of changes that shape the spatio-temporal patterns of circuit activation. Signals become more efficiently propagated across layers through developmentally regulated changes in interlaminar gain. |
| first_indexed | 2024-04-12T17:35:32Z |
| format | Article |
| id | doaj.art-1d0f6a552eee4566863c2ea9cf4f7d96 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-04-12T17:35:32Z |
| publishDate | 2013-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-1d0f6a552eee4566863c2ea9cf4f7d962022-12-22T03:23:00ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022013-01-01610.3389/fncel.2012.0006539055Developmental regulation of spatio-temporal patterns of cortical circuit activationTrevor Charles Griffen0Trevor Charles Griffen1Trevor Charles Griffen2Lang eWang3Alfredo eFontanini4Arianna eMaffei5SUNY Stony BrookStony Brook UniversityStony Brook UniversitySUNY Stony BrookSUNY Stony BrookSUNY Stony BrookNeural circuits are refined in an experience-dependent manner during early postnatal development. How development modulates the spatio-temporal propagation of activity through cortical circuits is poorly understood. Here we use voltage sensitive dye imaging (VSD) to show that there are significant changes in the spatio-temporal patterns of intracortical signals in primary visual cortex from postnatal day 13 (P13), eye opening, to P28, the peak of the critical period for rodent visual cortical plasticity. Upon direct stimulation of layer 4 (L4), activity spreads to L2/3 and to L5 at all ages. However, while from eye opening to the peak of the critical period, the amplitude and persistence of the voltage signal decrease, peak activation is reached more quickly and the interlaminar gain increases with age. The lateral spread of activation within layers remains unchanged throughout the time window under analysis. These developmental changes in spatio-temporal patterns of intracortical circuit activation are mediated by differences in the contributions of excitatory and inhibitory synaptic components. Our results demonstrate that after eye opening the circuit in primary visual cortex is refined through a progression of changes that shape the spatio-temporal patterns of circuit activation. Signals become more efficiently propagated across layers through developmentally regulated changes in interlaminar gain.http://journal.frontiersin.org/Journal/10.3389/fncel.2012.00065/fullVisual CortexGABANMDAsynaptic plasticityAMPApostnatal development |
| spellingShingle | Trevor Charles Griffen Trevor Charles Griffen Trevor Charles Griffen Lang eWang Alfredo eFontanini Arianna eMaffei Developmental regulation of spatio-temporal patterns of cortical circuit activation Frontiers in Cellular Neuroscience Visual Cortex GABA NMDA synaptic plasticity AMPA postnatal development |
| title | Developmental regulation of spatio-temporal patterns of cortical circuit activation |
| title_full | Developmental regulation of spatio-temporal patterns of cortical circuit activation |
| title_fullStr | Developmental regulation of spatio-temporal patterns of cortical circuit activation |
| title_full_unstemmed | Developmental regulation of spatio-temporal patterns of cortical circuit activation |
| title_short | Developmental regulation of spatio-temporal patterns of cortical circuit activation |
| title_sort | developmental regulation of spatio temporal patterns of cortical circuit activation |
| topic | Visual Cortex GABA NMDA synaptic plasticity AMPA postnatal development |
| url | http://journal.frontiersin.org/Journal/10.3389/fncel.2012.00065/full |
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