Regulating Pathways of <i>Bacillus pumilus</i> Adamalysin-like Metalloendopeptidase Expression
The minor secreted proteinase of <i>B. pumilus</i> 3-19 MprBp classified as the unique bacillary adamalysin-like enzyme of the metzincin clan. The functional role of this metalloproteinase in the bacilli cells is not clear. Analysis of the regulatory region of the <i>mprBp</i>...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-12-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/25/1/62 |
| Summary: | The minor secreted proteinase of <i>B. pumilus</i> 3-19 MprBp classified as the unique bacillary adamalysin-like enzyme of the metzincin clan. The functional role of this metalloproteinase in the bacilli cells is not clear. Analysis of the regulatory region of the <i>mprBp</i> gene showed the presence of potential binding sites to the transcription regulatory factors Spo0A (sporulation) and DegU (biodegradation). The study of <i>mprBp</i> activity in mutant strains of <i>B. subtilis</i> defective in regulatory proteins of the Spo- and Deg-systems showed that the <i>mprBp</i> gene is partially controlled by the Deg-system of signal transduction and independent from the Spo-system. |
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| ISSN: | 1661-6596 1422-0067 |