Regulating Pathways of <i>Bacillus pumilus</i> Adamalysin-like Metalloendopeptidase Expression
The minor secreted proteinase of <i>B. pumilus</i> 3-19 MprBp classified as the unique bacillary adamalysin-like enzyme of the metzincin clan. The functional role of this metalloproteinase in the bacilli cells is not clear. Analysis of the regulatory region of the <i>mprBp</i>...
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| Format: | Article |
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MDPI AG
2023-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/1/62 |
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| author | Natalia L. Rudakova Albina R. Sabirova Damir I. Khasanov Iuliia V. Danilova Margarita R. Sharipova |
| author_facet | Natalia L. Rudakova Albina R. Sabirova Damir I. Khasanov Iuliia V. Danilova Margarita R. Sharipova |
| author_sort | Natalia L. Rudakova |
| collection | DOAJ |
| description | The minor secreted proteinase of <i>B. pumilus</i> 3-19 MprBp classified as the unique bacillary adamalysin-like enzyme of the metzincin clan. The functional role of this metalloproteinase in the bacilli cells is not clear. Analysis of the regulatory region of the <i>mprBp</i> gene showed the presence of potential binding sites to the transcription regulatory factors Spo0A (sporulation) and DegU (biodegradation). The study of <i>mprBp</i> activity in mutant strains of <i>B. subtilis</i> defective in regulatory proteins of the Spo- and Deg-systems showed that the <i>mprBp</i> gene is partially controlled by the Deg-system of signal transduction and independent from the Spo-system. |
| first_indexed | 2024-03-08T15:06:06Z |
| format | Article |
| id | doaj.art-1d0fde889d524514be3c4cee1989b3bd |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-08T15:06:06Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-1d0fde889d524514be3c4cee1989b3bd2024-01-10T14:58:01ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-12-012516210.3390/ijms25010062Regulating Pathways of <i>Bacillus pumilus</i> Adamalysin-like Metalloendopeptidase ExpressionNatalia L. Rudakova0Albina R. Sabirova1Damir I. Khasanov2Iuliia V. Danilova3Margarita R. Sharipova4Institute of Fundamental Medicine, Kazan Federal University, Kremlevskaya St. 18, 420008 Kazan, RussiaInstitute of Fundamental Medicine, Kazan Federal University, Kremlevskaya St. 18, 420008 Kazan, RussiaInstitute of Fundamental Medicine, Kazan Federal University, Kremlevskaya St. 18, 420008 Kazan, RussiaInstitute of Fundamental Medicine, Kazan Federal University, Kremlevskaya St. 18, 420008 Kazan, RussiaInstitute of Fundamental Medicine, Kazan Federal University, Kremlevskaya St. 18, 420008 Kazan, RussiaThe minor secreted proteinase of <i>B. pumilus</i> 3-19 MprBp classified as the unique bacillary adamalysin-like enzyme of the metzincin clan. The functional role of this metalloproteinase in the bacilli cells is not clear. Analysis of the regulatory region of the <i>mprBp</i> gene showed the presence of potential binding sites to the transcription regulatory factors Spo0A (sporulation) and DegU (biodegradation). The study of <i>mprBp</i> activity in mutant strains of <i>B. subtilis</i> defective in regulatory proteins of the Spo- and Deg-systems showed that the <i>mprBp</i> gene is partially controlled by the Deg-system of signal transduction and independent from the Spo-system.https://www.mdpi.com/1422-0067/25/1/62Spo0ADegUsignal transduction systemsporulationregulatory mutants |
| spellingShingle | Natalia L. Rudakova Albina R. Sabirova Damir I. Khasanov Iuliia V. Danilova Margarita R. Sharipova Regulating Pathways of <i>Bacillus pumilus</i> Adamalysin-like Metalloendopeptidase Expression International Journal of Molecular Sciences Spo0A DegU signal transduction system sporulation regulatory mutants |
| title | Regulating Pathways of <i>Bacillus pumilus</i> Adamalysin-like Metalloendopeptidase Expression |
| title_full | Regulating Pathways of <i>Bacillus pumilus</i> Adamalysin-like Metalloendopeptidase Expression |
| title_fullStr | Regulating Pathways of <i>Bacillus pumilus</i> Adamalysin-like Metalloendopeptidase Expression |
| title_full_unstemmed | Regulating Pathways of <i>Bacillus pumilus</i> Adamalysin-like Metalloendopeptidase Expression |
| title_short | Regulating Pathways of <i>Bacillus pumilus</i> Adamalysin-like Metalloendopeptidase Expression |
| title_sort | regulating pathways of i bacillus pumilus i adamalysin like metalloendopeptidase expression |
| topic | Spo0A DegU signal transduction system sporulation regulatory mutants |
| url | https://www.mdpi.com/1422-0067/25/1/62 |
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