The therapeutic value of thiazole and thiazolidine derivatives in Alzheimer's disease: a systematic literature review
Background and purpose: Alzheimer's disease (AD) is a common neurodegenerative disease and the fifth leading cause of death among the elderly. The development of drugs for AD treatment is based on inhibiting cholinesterase (ChE) activity and inhibiting amyloid-beta peptide and tau protein aggre...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Research in Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2024;volume=19;issue=1;spage=1;epage=12;aulast=Abdollahi |
| _version_ | 1827309258867212288 |
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| author | Zahra Abdollahi Mojgan Nejabat Khalil Abnous Farzin Hadizadeh |
| author_facet | Zahra Abdollahi Mojgan Nejabat Khalil Abnous Farzin Hadizadeh |
| author_sort | Zahra Abdollahi |
| collection | DOAJ |
| description | Background and purpose: Alzheimer's disease (AD) is a common neurodegenerative disease and the fifth leading cause of death among the elderly. The development of drugs for AD treatment is based on inhibiting cholinesterase (ChE) activity and inhibiting amyloid-beta peptide and tau protein aggregations. Many in vitro findings have demonstrated that thiazole- and thiazolidine-based compounds have a good inhibitory effect on ChE and other elements involved in the AD pathogenicity cascade.
Experimental approach: In the present review, we collected available documents to verify whether these synthetic compounds can be a step forward in developing new medications for AD. A systematic literature search was performed in major electronic databases in April 2021. Twenty-eight relevant in vitro and in vivo studies were found and used for data extraction.
Findings/Results: Findings demonstrated that thiazole- and thiazolidine-based compounds could ameliorate AD's pathologic condition by affecting various targets, including inhibition of ChE activity, amyloid-beta, and tau aggregation in addition to cyclin-dependent kinase 5/p25, beta-secretase-1, cyclooxygenase, and glycogen synthase kinase-3β.
Conclusion and implications: Due to multitarget effects at micromolar concentration, this review demonstrated that these synthetic compounds could be considered promising candidates for developing anti-Alzheimer drugs. |
| first_indexed | 2024-04-24T19:36:04Z |
| format | Article |
| id | doaj.art-1d11471833b04d098a5462237a825275 |
| institution | Directory Open Access Journal |
| issn | 1735-5362 1735-9414 |
| language | English |
| last_indexed | 2024-04-24T19:36:04Z |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Research in Pharmaceutical Sciences |
| spelling | doaj.art-1d11471833b04d098a5462237a8252752024-03-25T13:04:12ZengWolters Kluwer Medknow PublicationsResearch in Pharmaceutical Sciences1735-53621735-94142024-01-0119111210.4103/1735-5362.394816The therapeutic value of thiazole and thiazolidine derivatives in Alzheimer's disease: a systematic literature reviewZahra AbdollahiMojgan NejabatKhalil AbnousFarzin HadizadehBackground and purpose: Alzheimer's disease (AD) is a common neurodegenerative disease and the fifth leading cause of death among the elderly. The development of drugs for AD treatment is based on inhibiting cholinesterase (ChE) activity and inhibiting amyloid-beta peptide and tau protein aggregations. Many in vitro findings have demonstrated that thiazole- and thiazolidine-based compounds have a good inhibitory effect on ChE and other elements involved in the AD pathogenicity cascade. Experimental approach: In the present review, we collected available documents to verify whether these synthetic compounds can be a step forward in developing new medications for AD. A systematic literature search was performed in major electronic databases in April 2021. Twenty-eight relevant in vitro and in vivo studies were found and used for data extraction. Findings/Results: Findings demonstrated that thiazole- and thiazolidine-based compounds could ameliorate AD's pathologic condition by affecting various targets, including inhibition of ChE activity, amyloid-beta, and tau aggregation in addition to cyclin-dependent kinase 5/p25, beta-secretase-1, cyclooxygenase, and glycogen synthase kinase-3β. Conclusion and implications: Due to multitarget effects at micromolar concentration, this review demonstrated that these synthetic compounds could be considered promising candidates for developing anti-Alzheimer drugs.http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2024;volume=19;issue=1;spage=1;epage=12;aulast=Abdollahialzheimer's disease; amyloid beta; cholinesterase; glycogen synthase kinase; thiazolidine; thiazole. |
| spellingShingle | Zahra Abdollahi Mojgan Nejabat Khalil Abnous Farzin Hadizadeh The therapeutic value of thiazole and thiazolidine derivatives in Alzheimer's disease: a systematic literature review Research in Pharmaceutical Sciences alzheimer's disease; amyloid beta; cholinesterase; glycogen synthase kinase; thiazolidine; thiazole. |
| title | The therapeutic value of thiazole and thiazolidine derivatives in Alzheimer's disease: a systematic literature review |
| title_full | The therapeutic value of thiazole and thiazolidine derivatives in Alzheimer's disease: a systematic literature review |
| title_fullStr | The therapeutic value of thiazole and thiazolidine derivatives in Alzheimer's disease: a systematic literature review |
| title_full_unstemmed | The therapeutic value of thiazole and thiazolidine derivatives in Alzheimer's disease: a systematic literature review |
| title_short | The therapeutic value of thiazole and thiazolidine derivatives in Alzheimer's disease: a systematic literature review |
| title_sort | therapeutic value of thiazole and thiazolidine derivatives in alzheimer s disease a systematic literature review |
| topic | alzheimer's disease; amyloid beta; cholinesterase; glycogen synthase kinase; thiazolidine; thiazole. |
| url | http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2024;volume=19;issue=1;spage=1;epage=12;aulast=Abdollahi |
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