Disconnected circadian and cell cycles in a tumor-driven cell line
Cell division occurs at a specific time of day in numerous species, suggesting that the circadian and cell cycles are coupled in vivo. By measuring the cell cycle rhythm in real-time, we recently showed that the circadian and cell cycles are not coupled in immortalized fibroblasts, resulting in a ra...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2010-11-01
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| Series: | Communicative & Integrative Biology |
| Online Access: | https://www.tandfonline.com/doi/10.4161/cib.3.6.12841 |
| _version_ | 1797683789044908032 |
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| author | Julie S. Pendergast Mijung Yeom Bryan A. Reyes Yoshihiro Ohmiya Shin Yamazaki |
| author_facet | Julie S. Pendergast Mijung Yeom Bryan A. Reyes Yoshihiro Ohmiya Shin Yamazaki |
| author_sort | Julie S. Pendergast |
| collection | DOAJ |
| description | Cell division occurs at a specific time of day in numerous species, suggesting that the circadian and cell cycles are coupled in vivo. By measuring the cell cycle rhythm in real-time, we recently showed that the circadian and cell cycles are not coupled in immortalized fibroblasts, resulting in a rapid rate of cell division even though the circadian rhythm is normal in these cells. Here we report that tumor-driven Lewis Lung Carcinoma (LLC) cells have perfectly temperature compensated circadian clocks, but the periods of their cell cycle gene expression rhythms are temperature-dependent, suggesting that their circadian and cell cycles are not connected. These data support our hypothesis that decoupling of the circadian and cell cycles may underlie aberrant cell division in tumor cells. |
| first_indexed | 2024-03-12T00:20:54Z |
| format | Article |
| id | doaj.art-1d11b6c5b0b34b91b306c384c04657c2 |
| institution | Directory Open Access Journal |
| issn | 1942-0889 |
| language | English |
| last_indexed | 2024-03-12T00:20:54Z |
| publishDate | 2010-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Communicative & Integrative Biology |
| spelling | doaj.art-1d11b6c5b0b34b91b306c384c04657c22023-09-15T13:06:45ZengTaylor & Francis GroupCommunicative & Integrative Biology1942-08892010-11-013653653910.4161/cib.3.6.12841Disconnected circadian and cell cycles in a tumor-driven cell lineJulie S. Pendergast0Mijung Yeom1Bryan A. Reyes2Yoshihiro Ohmiya3Shin Yamazaki4Department of Biological Sciences, Vanderbilt University, Nashville, TN USADepartment of Biological Sciences, Vanderbilt University, Nashville, TN USADepartment of Biological Sciences, Vanderbilt University, Nashville, TN USABioproduction Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki JapanDepartment of Biological Sciences, Vanderbilt University, Nashville, TN USACell division occurs at a specific time of day in numerous species, suggesting that the circadian and cell cycles are coupled in vivo. By measuring the cell cycle rhythm in real-time, we recently showed that the circadian and cell cycles are not coupled in immortalized fibroblasts, resulting in a rapid rate of cell division even though the circadian rhythm is normal in these cells. Here we report that tumor-driven Lewis Lung Carcinoma (LLC) cells have perfectly temperature compensated circadian clocks, but the periods of their cell cycle gene expression rhythms are temperature-dependent, suggesting that their circadian and cell cycles are not connected. These data support our hypothesis that decoupling of the circadian and cell cycles may underlie aberrant cell division in tumor cells.https://www.tandfonline.com/doi/10.4161/cib.3.6.12841 |
| spellingShingle | Julie S. Pendergast Mijung Yeom Bryan A. Reyes Yoshihiro Ohmiya Shin Yamazaki Disconnected circadian and cell cycles in a tumor-driven cell line Communicative & Integrative Biology |
| title | Disconnected circadian and cell cycles in a tumor-driven cell line |
| title_full | Disconnected circadian and cell cycles in a tumor-driven cell line |
| title_fullStr | Disconnected circadian and cell cycles in a tumor-driven cell line |
| title_full_unstemmed | Disconnected circadian and cell cycles in a tumor-driven cell line |
| title_short | Disconnected circadian and cell cycles in a tumor-driven cell line |
| title_sort | disconnected circadian and cell cycles in a tumor driven cell line |
| url | https://www.tandfonline.com/doi/10.4161/cib.3.6.12841 |
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