The roles of connexins and gap junctions in the progression of cancer
Abstract Gap junctions (GJs), which are composed of connexins (Cxs), provide channels for direct information exchange between cells. Cx expression has a strong spatial specificity; however, its influence on cell behavior and information exchange between cells cannot be ignored. A variety of factors...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-022-01009-9 |
| _version_ | 1828063575252402176 |
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| author | Mingming Zhou Minying Zheng Xinyue Zhou Shifeng Tian Xiaohui Yang Yidi Ning Yuwei Li Shiwu Zhang |
| author_facet | Mingming Zhou Minying Zheng Xinyue Zhou Shifeng Tian Xiaohui Yang Yidi Ning Yuwei Li Shiwu Zhang |
| author_sort | Mingming Zhou |
| collection | DOAJ |
| description | Abstract Gap junctions (GJs), which are composed of connexins (Cxs), provide channels for direct information exchange between cells. Cx expression has a strong spatial specificity; however, its influence on cell behavior and information exchange between cells cannot be ignored. A variety of factors in organisms can modulate Cxs and subsequently trigger a series of responses that have important effects on cellular behavior. The expression and function of Cxs and the number and function of GJs are in dynamic change. Cxs have been characterized as tumor suppressors in the past, but recent studies have highlighted the critical roles of Cxs and GJs in cancer pathogenesis. The complex mechanism underlying Cx and GJ involvement in cancer development is a major obstacle to the evolution of therapy targeting Cxs. In this paper, we review the post-translational modifications of Cxs, the interactions of Cxs with several chaperone proteins, and the effects of Cxs and GJs on cancer. Video Abstract |
| first_indexed | 2024-04-10T22:46:44Z |
| format | Article |
| id | doaj.art-1d11e54395ea4f36a278b884c5df76c9 |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-04-10T22:46:44Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-1d11e54395ea4f36a278b884c5df76c92023-01-15T12:16:57ZengBMCCell Communication and Signaling1478-811X2023-01-0121111910.1186/s12964-022-01009-9The roles of connexins and gap junctions in the progression of cancerMingming Zhou0Minying Zheng1Xinyue Zhou2Shifeng Tian3Xiaohui Yang4Yidi Ning5Yuwei Li6Shiwu Zhang7Graduate School, Tianjin Medical UniversityDepartment of Pathology, Tianjin Union Medical Center, Nankai UniversityGraduate School, Tianjin Medical UniversityGraduate School, Tianjin Medical UniversityNankai University School of Medicine, Nankai UniversityNankai University School of Medicine, Nankai UniversityDepartment of Colorectal Surgery, Tianjin Union Medical CenterDepartment of Pathology, Tianjin Union Medical Center, Nankai UniversityAbstract Gap junctions (GJs), which are composed of connexins (Cxs), provide channels for direct information exchange between cells. Cx expression has a strong spatial specificity; however, its influence on cell behavior and information exchange between cells cannot be ignored. A variety of factors in organisms can modulate Cxs and subsequently trigger a series of responses that have important effects on cellular behavior. The expression and function of Cxs and the number and function of GJs are in dynamic change. Cxs have been characterized as tumor suppressors in the past, but recent studies have highlighted the critical roles of Cxs and GJs in cancer pathogenesis. The complex mechanism underlying Cx and GJ involvement in cancer development is a major obstacle to the evolution of therapy targeting Cxs. In this paper, we review the post-translational modifications of Cxs, the interactions of Cxs with several chaperone proteins, and the effects of Cxs and GJs on cancer. Video Abstracthttps://doi.org/10.1186/s12964-022-01009-9Gap junctionsConnexinsPost-translational modificationCancerEpithelial–mesenchymal transition |
| spellingShingle | Mingming Zhou Minying Zheng Xinyue Zhou Shifeng Tian Xiaohui Yang Yidi Ning Yuwei Li Shiwu Zhang The roles of connexins and gap junctions in the progression of cancer Cell Communication and Signaling Gap junctions Connexins Post-translational modification Cancer Epithelial–mesenchymal transition |
| title | The roles of connexins and gap junctions in the progression of cancer |
| title_full | The roles of connexins and gap junctions in the progression of cancer |
| title_fullStr | The roles of connexins and gap junctions in the progression of cancer |
| title_full_unstemmed | The roles of connexins and gap junctions in the progression of cancer |
| title_short | The roles of connexins and gap junctions in the progression of cancer |
| title_sort | roles of connexins and gap junctions in the progression of cancer |
| topic | Gap junctions Connexins Post-translational modification Cancer Epithelial–mesenchymal transition |
| url | https://doi.org/10.1186/s12964-022-01009-9 |
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