Safety Study of Doxicycline in Broiler Chickens
Doxicycline is a structural isomer who meets the European reference standard (Ph.Eur. III 1997:0272) and respect EU Regulations for M.R.L. The good solubility permits high tissular absorption and distribution after administration in drinking water. The aim was to ascertain the clinical effects and t...
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| Format: | Article |
| Language: | English |
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Agroprint Timisoara
2023-10-01
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| Series: | Scientific Papers Animal Science and Biotechnologies |
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| Online Access: | https://spasb.ro/index.php/public_html/article/view/1348 |
| _version_ | 1797215741767843840 |
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| author | Romeo Teodor Cristina Ivo Schmerold Eugenia Dumitrescu Diana Brezovan Snejana Petrovici Sorin Paidac |
| author_facet | Romeo Teodor Cristina Ivo Schmerold Eugenia Dumitrescu Diana Brezovan Snejana Petrovici Sorin Paidac |
| author_sort | Romeo Teodor Cristina |
| collection | DOAJ |
| description | Doxicycline is a structural isomer who meets the European reference standard (Ph.Eur. III 1997:0272) and respect EU Regulations for M.R.L. The good solubility permits high tissular absorption and distribution after administration in drinking water. The aim was to ascertain the clinical effects and tolerance consecutive to risen doses administration, as a part of safety study for this antibiotic in poultry in the respect of current drug testing methodology. The safety study revealed: good local and general tolerance to therapeutic doses (10 mg x kgb.w.-1) and to x2 dose, diarrhoea in lots which received x3 and x5 the therapeutic dose. Comparatively with the Control lot, haemoleucogram doesn’t suffer evident changes the registered values being between the references limits (exception of leucocitary formula). Also it was found an increased creatinin concentration consecutively to x3 and x5 greater doses administration and marked increasing of ASAT level and limited for ALAT’s, comparatively to control lot in the case of E4 lot, but light to reference values. Macro and microscopy revealed for the liver samples: hepatomegaly, diffuse hepatic degenerescence, nuclear heterochromatinization, vacuolar degenerescence; renal changes in nefrons and renal corpuscles, light splenomegaly, caecal sacs distension and brown-yellowish gaseous content to lots E3 and E4. |
| first_indexed | 2024-04-24T11:34:53Z |
| format | Article |
| id | doaj.art-1d13ac76fca04630a9d12e21ed8baa7c |
| institution | Directory Open Access Journal |
| issn | 1841-9364 2344-4576 |
| language | English |
| last_indexed | 2024-04-24T11:34:53Z |
| publishDate | 2023-10-01 |
| publisher | Agroprint Timisoara |
| record_format | Article |
| series | Scientific Papers Animal Science and Biotechnologies |
| spelling | doaj.art-1d13ac76fca04630a9d12e21ed8baa7c2024-04-10T06:50:47ZengAgroprint TimisoaraScientific Papers Animal Science and Biotechnologies1841-93642344-45762023-10-014314744741348Safety Study of Doxicycline in Broiler ChickensRomeo Teodor Cristina0Ivo Schmerold1Eugenia Dumitrescu2Diana Brezovan3Snejana Petrovici4Sorin Paidac5Banat’s University of Agricultural Sciences and Veterinary Medicine, Faculty of Veterinary Medicine, Veterinary Pharmacology and Pharmacy Depts., Calea Aradului, 119, 300645, Timisoara, RomaniaVeterinary University of Vienna, Institute of Pharmacology and Toxicology, Veterinärplatz 1 A-1210 WienBanat’s University of Agricultural Sciences and Veterinary Medicine, Faculty of Veterinary Medicine, Veterinary Pharmacology and Pharmacy Depts., Calea Aradului, 119, 300645, Timisoara, RomaniaBanat’s University of Agricultural Sciences and Veterinary Medicine, Faculty of Veterinary Medicine, Veterinary Pharmacology and Pharmacy Depts., Calea Aradului, 119, 300645, Timisoara, RomaniaBanat’s University of Agricultural Sciences and Veterinary Medicine, Faculty of Veterinary Medicine, Veterinary Pharmacology and Pharmacy Depts., Calea Aradului, 119, 300645, Timisoara, RomaniaBanat’s University of Agricultural Sciences and Veterinary Medicine, Faculty of Veterinary Medicine, Veterinary Pharmacology and Pharmacy Depts., Calea Aradului, 119, 300645, Timisoara, RomaniaDoxicycline is a structural isomer who meets the European reference standard (Ph.Eur. III 1997:0272) and respect EU Regulations for M.R.L. The good solubility permits high tissular absorption and distribution after administration in drinking water. The aim was to ascertain the clinical effects and tolerance consecutive to risen doses administration, as a part of safety study for this antibiotic in poultry in the respect of current drug testing methodology. The safety study revealed: good local and general tolerance to therapeutic doses (10 mg x kgb.w.-1) and to x2 dose, diarrhoea in lots which received x3 and x5 the therapeutic dose. Comparatively with the Control lot, haemoleucogram doesn’t suffer evident changes the registered values being between the references limits (exception of leucocitary formula). Also it was found an increased creatinin concentration consecutively to x3 and x5 greater doses administration and marked increasing of ASAT level and limited for ALAT’s, comparatively to control lot in the case of E4 lot, but light to reference values. Macro and microscopy revealed for the liver samples: hepatomegaly, diffuse hepatic degenerescence, nuclear heterochromatinization, vacuolar degenerescence; renal changes in nefrons and renal corpuscles, light splenomegaly, caecal sacs distension and brown-yellowish gaseous content to lots E3 and E4.https://spasb.ro/index.php/public_html/article/view/1348doxicyclinetolerancebroiler chickensafety study |
| spellingShingle | Romeo Teodor Cristina Ivo Schmerold Eugenia Dumitrescu Diana Brezovan Snejana Petrovici Sorin Paidac Safety Study of Doxicycline in Broiler Chickens Scientific Papers Animal Science and Biotechnologies doxicycline tolerance broiler chicken safety study |
| title | Safety Study of Doxicycline in Broiler Chickens |
| title_full | Safety Study of Doxicycline in Broiler Chickens |
| title_fullStr | Safety Study of Doxicycline in Broiler Chickens |
| title_full_unstemmed | Safety Study of Doxicycline in Broiler Chickens |
| title_short | Safety Study of Doxicycline in Broiler Chickens |
| title_sort | safety study of doxicycline in broiler chickens |
| topic | doxicycline tolerance broiler chicken safety study |
| url | https://spasb.ro/index.php/public_html/article/view/1348 |
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