Extracellular vesicles: novel communicators in lung diseases
Abstract The lung is the organ with the highest vascular density in the human body. It is therefore perceivable that the endothelium of the lung contributes significantly to the circulation of extracellular vesicles (EVs), which include exosomes, microvesicles, and apoptotic bodies. In addition to t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-07-01
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| Series: | Respiratory Research |
| Online Access: | http://link.springer.com/article/10.1186/s12931-020-01423-y |
| _version_ | 1819039265083883520 |
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| author | Aradhana Mohan Stuti Agarwal Matthias Clauss Nicholas S. Britt Navneet K. Dhillon |
| author_facet | Aradhana Mohan Stuti Agarwal Matthias Clauss Nicholas S. Britt Navneet K. Dhillon |
| author_sort | Aradhana Mohan |
| collection | DOAJ |
| description | Abstract The lung is the organ with the highest vascular density in the human body. It is therefore perceivable that the endothelium of the lung contributes significantly to the circulation of extracellular vesicles (EVs), which include exosomes, microvesicles, and apoptotic bodies. In addition to the endothelium, EVs may arise from alveolar macrophages, fibroblasts and epithelial cells. Because EVs harbor cargo molecules, such as miRNA, mRNA, and proteins, these intercellular communicators provide important insight into the health and disease condition of donor cells and may serve as useful biomarkers of lung disease processes. This comprehensive review focuses on what is currently known about the role of EVs as markers and mediators of lung pathologies including COPD, pulmonary hypertension, asthma, lung cancer and ALI/ARDS. We also explore the role EVs can potentially serve as therapeutics for these lung diseases when released from healthy progenitor cells, such as mesenchymal stem cells. |
| first_indexed | 2024-12-21T08:50:27Z |
| format | Article |
| id | doaj.art-1d13df90fd7c44028a534dfd544511d2 |
| institution | Directory Open Access Journal |
| issn | 1465-993X |
| language | English |
| last_indexed | 2024-12-21T08:50:27Z |
| publishDate | 2020-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-1d13df90fd7c44028a534dfd544511d22022-12-21T19:09:42ZengBMCRespiratory Research1465-993X2020-07-0121112110.1186/s12931-020-01423-yExtracellular vesicles: novel communicators in lung diseasesAradhana Mohan0Stuti Agarwal1Matthias Clauss2Nicholas S. Britt3Navneet K. Dhillon4Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Kansas Medical CenterDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Kansas Medical CenterDivision of Pulmonary, Critical Care, Sleep & Occupational Medicine, Indiana University School of MedicineDepartment of Pharmacy Practice, University of Kansas School of PharmacyDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Kansas Medical CenterAbstract The lung is the organ with the highest vascular density in the human body. It is therefore perceivable that the endothelium of the lung contributes significantly to the circulation of extracellular vesicles (EVs), which include exosomes, microvesicles, and apoptotic bodies. In addition to the endothelium, EVs may arise from alveolar macrophages, fibroblasts and epithelial cells. Because EVs harbor cargo molecules, such as miRNA, mRNA, and proteins, these intercellular communicators provide important insight into the health and disease condition of donor cells and may serve as useful biomarkers of lung disease processes. This comprehensive review focuses on what is currently known about the role of EVs as markers and mediators of lung pathologies including COPD, pulmonary hypertension, asthma, lung cancer and ALI/ARDS. We also explore the role EVs can potentially serve as therapeutics for these lung diseases when released from healthy progenitor cells, such as mesenchymal stem cells.http://link.springer.com/article/10.1186/s12931-020-01423-y |
| spellingShingle | Aradhana Mohan Stuti Agarwal Matthias Clauss Nicholas S. Britt Navneet K. Dhillon Extracellular vesicles: novel communicators in lung diseases Respiratory Research |
| title | Extracellular vesicles: novel communicators in lung diseases |
| title_full | Extracellular vesicles: novel communicators in lung diseases |
| title_fullStr | Extracellular vesicles: novel communicators in lung diseases |
| title_full_unstemmed | Extracellular vesicles: novel communicators in lung diseases |
| title_short | Extracellular vesicles: novel communicators in lung diseases |
| title_sort | extracellular vesicles novel communicators in lung diseases |
| url | http://link.springer.com/article/10.1186/s12931-020-01423-y |
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