Potential Psychoactive Effects of Microalgal Bioactive Compounds for the Case of Sleep and Mood Regulation: Opportunities and Challenges
Sleep deficiency is now considered an emerging global epidemic associated with many serious health problems, and a major cause of financial and social burdens. Sleep and mental health are closely connected, further exacerbating the negative impact of sleep deficiency on overall health and well-being...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/20/8/493 |
| _version_ | 1797443812736368640 |
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| author | Bozena McCarthy Graham O’Neill Nissreen Abu-Ghannam |
| author_facet | Bozena McCarthy Graham O’Neill Nissreen Abu-Ghannam |
| author_sort | Bozena McCarthy |
| collection | DOAJ |
| description | Sleep deficiency is now considered an emerging global epidemic associated with many serious health problems, and a major cause of financial and social burdens. Sleep and mental health are closely connected, further exacerbating the negative impact of sleep deficiency on overall health and well-being. A major drawback of conventional treatments is the wide range of undesirable side-effects typically associated with benzodiazepines and antidepressants, which can be more debilitating than the initial disorder. It is therefore valuable to explore the efficiency of other remedies for complementarity and synergism with existing conventional treatments, leading to possible reduction in undesirable side-effects. This review explores the relevance of microalgae bioactives as a sustainable source of valuable phytochemicals that can contribute positively to mood and sleep disorders. Microalgae species producing these compounds are also catalogued, thus creating a useful reference of the state of the art for further exploration of this proposed approach. While we highlight possibilities awaiting investigation, we also identify the associated issues, including minimum dose for therapeutic effect, bioavailability, possible interactions with conventional treatments and the ability to cross the blood brain barrier. We conclude that physical and biological functionalization of microalgae bioactives can have potential in overcoming some of these challenges. |
| first_indexed | 2024-03-09T13:02:26Z |
| format | Article |
| id | doaj.art-1d1470a834a34ec09cffd15c5f400fac |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-09T13:02:26Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-1d1470a834a34ec09cffd15c5f400fac2023-11-30T21:51:46ZengMDPI AGMarine Drugs1660-33972022-07-0120849310.3390/md20080493Potential Psychoactive Effects of Microalgal Bioactive Compounds for the Case of Sleep and Mood Regulation: Opportunities and ChallengesBozena McCarthy0Graham O’Neill1Nissreen Abu-Ghannam2Environmental Sustainability & Health Institute (ESHI), Technological University Dublin, Grangegorman, D07 H6K8 Dublin 7, IrelandEnvironmental Sustainability & Health Institute (ESHI), Technological University Dublin, Grangegorman, D07 H6K8 Dublin 7, IrelandEnvironmental Sustainability & Health Institute (ESHI), Technological University Dublin, Grangegorman, D07 H6K8 Dublin 7, IrelandSleep deficiency is now considered an emerging global epidemic associated with many serious health problems, and a major cause of financial and social burdens. Sleep and mental health are closely connected, further exacerbating the negative impact of sleep deficiency on overall health and well-being. A major drawback of conventional treatments is the wide range of undesirable side-effects typically associated with benzodiazepines and antidepressants, which can be more debilitating than the initial disorder. It is therefore valuable to explore the efficiency of other remedies for complementarity and synergism with existing conventional treatments, leading to possible reduction in undesirable side-effects. This review explores the relevance of microalgae bioactives as a sustainable source of valuable phytochemicals that can contribute positively to mood and sleep disorders. Microalgae species producing these compounds are also catalogued, thus creating a useful reference of the state of the art for further exploration of this proposed approach. While we highlight possibilities awaiting investigation, we also identify the associated issues, including minimum dose for therapeutic effect, bioavailability, possible interactions with conventional treatments and the ability to cross the blood brain barrier. We conclude that physical and biological functionalization of microalgae bioactives can have potential in overcoming some of these challenges.https://www.mdpi.com/1660-3397/20/8/493microalgaebioactive compoundspolyunsaturated fatty acidspigmentssleepmood regulation |
| spellingShingle | Bozena McCarthy Graham O’Neill Nissreen Abu-Ghannam Potential Psychoactive Effects of Microalgal Bioactive Compounds for the Case of Sleep and Mood Regulation: Opportunities and Challenges Marine Drugs microalgae bioactive compounds polyunsaturated fatty acids pigments sleep mood regulation |
| title | Potential Psychoactive Effects of Microalgal Bioactive Compounds for the Case of Sleep and Mood Regulation: Opportunities and Challenges |
| title_full | Potential Psychoactive Effects of Microalgal Bioactive Compounds for the Case of Sleep and Mood Regulation: Opportunities and Challenges |
| title_fullStr | Potential Psychoactive Effects of Microalgal Bioactive Compounds for the Case of Sleep and Mood Regulation: Opportunities and Challenges |
| title_full_unstemmed | Potential Psychoactive Effects of Microalgal Bioactive Compounds for the Case of Sleep and Mood Regulation: Opportunities and Challenges |
| title_short | Potential Psychoactive Effects of Microalgal Bioactive Compounds for the Case of Sleep and Mood Regulation: Opportunities and Challenges |
| title_sort | potential psychoactive effects of microalgal bioactive compounds for the case of sleep and mood regulation opportunities and challenges |
| topic | microalgae bioactive compounds polyunsaturated fatty acids pigments sleep mood regulation |
| url | https://www.mdpi.com/1660-3397/20/8/493 |
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