Single‐Cell Transcriptomics of Engineered Cardiac Tissues From Patient‐Specific Induced Pluripotent Stem Cell–Derived Cardiomyocytes Reveals Abnormal Developmental Trajectory and Intrinsic Contractile Defects in Hypoplastic Right Heart Syndrome

Single‐Cell Transcriptomics of Engineered Cardiac Tissues From Patient‐Specific Induced Pluripotent Stem Cell–Derived Cardiomyocytes Reveals Abnormal Developmental Trajectory and Intrinsic Contractile Defects in Hypoplastic Right Heart Syndrome

Background To understand the intrinsic cardiac developmental and functional abnormalities in pulmonary atresia with intact ventricular septum (PAIVS) free from effects secondary to anatomic defects, we performed and compared single‐cell transcriptomic and phenotypic analyses of patient‐ and healthy...

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Bibliographic Details
Main Authors: Yin‐Yu Lam, Wendy Keung, Chun‐Ho Chan, Lin Geng, Nicodemus Wong, David Brenière‐Letuffe, Ronald A. Li, Yiu‐Fai Cheung
Format: Article
Language:English
Published: Wiley 2020-10-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
hypoplastic right heart syndrome
induced pluripotent stem cells
pulmonary atresia with intact ventricular septum
single cell transcriptomics
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.120.016528

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