The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans

The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans

lncRNAs are transcriptional regulators, but little is known of them functioning as negative feedback regulators of inflammation in humans. Here, the authors show that the human lncRNA LUCAT1 sequesters STAT1 to limit JAK/STAT signaling and the inflammatory response to viral infection or TLR stimulat...

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Bibliographic Details
Main Authors: Shiuli Agarwal, Tim Vierbuchen, Sreya Ghosh, Jennie Chan, Zhaozhao Jiang, Richard K. Kandasamy, Emiliano Ricci, Katherine A. Fitzgerald
Format: Article
Language:English
Published: Nature Portfolio 2020-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20165-5
Description
Summary:lncRNAs are transcriptional regulators, but little is known of them functioning as negative feedback regulators of inflammation in humans. Here, the authors show that the human lncRNA LUCAT1 sequesters STAT1 to limit JAK/STAT signaling and the inflammatory response to viral infection or TLR stimulation in myeloid cells.
ISSN:2041-1723

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