The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans
lncRNAs are transcriptional regulators, but little is known of them functioning as negative feedback regulators of inflammation in humans. Here, the authors show that the human lncRNA LUCAT1 sequesters STAT1 to limit JAK/STAT signaling and the inflammatory response to viral infection or TLR stimulat...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-20165-5 |
| _version_ | 1818993660662906880 |
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| author | Shiuli Agarwal Tim Vierbuchen Sreya Ghosh Jennie Chan Zhaozhao Jiang Richard K. Kandasamy Emiliano Ricci Katherine A. Fitzgerald |
| author_facet | Shiuli Agarwal Tim Vierbuchen Sreya Ghosh Jennie Chan Zhaozhao Jiang Richard K. Kandasamy Emiliano Ricci Katherine A. Fitzgerald |
| author_sort | Shiuli Agarwal |
| collection | DOAJ |
| description | lncRNAs are transcriptional regulators, but little is known of them functioning as negative feedback regulators of inflammation in humans. Here, the authors show that the human lncRNA LUCAT1 sequesters STAT1 to limit JAK/STAT signaling and the inflammatory response to viral infection or TLR stimulation in myeloid cells. |
| first_indexed | 2024-12-20T20:45:35Z |
| format | Article |
| id | doaj.art-1d15ab27155343e5bc98b57512bbe82b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T20:45:35Z |
| publishDate | 2020-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-1d15ab27155343e5bc98b57512bbe82b2022-12-21T19:27:02ZengNature PortfolioNature Communications2041-17232020-12-0111111110.1038/s41467-020-20165-5The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humansShiuli Agarwal0Tim Vierbuchen1Sreya Ghosh2Jennie Chan3Zhaozhao Jiang4Richard K. Kandasamy5Emiliano Ricci6Katherine A. Fitzgerald7Program in Innate Immunity, University of Massachusetts Medical SchoolProgram in Innate Immunity, University of Massachusetts Medical SchoolProgram in Innate Immunity, University of Massachusetts Medical SchoolProgram in Innate Immunity, University of Massachusetts Medical SchoolProgram in Innate Immunity, University of Massachusetts Medical SchoolCentre of Molecular Inflammation Research (CEMIR), Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and TechnologyUniversité de Lyon, ENSL, UCBL, CNRS, INSERM, LBMCProgram in Innate Immunity, University of Massachusetts Medical SchoollncRNAs are transcriptional regulators, but little is known of them functioning as negative feedback regulators of inflammation in humans. Here, the authors show that the human lncRNA LUCAT1 sequesters STAT1 to limit JAK/STAT signaling and the inflammatory response to viral infection or TLR stimulation in myeloid cells.https://doi.org/10.1038/s41467-020-20165-5 |
| spellingShingle | Shiuli Agarwal Tim Vierbuchen Sreya Ghosh Jennie Chan Zhaozhao Jiang Richard K. Kandasamy Emiliano Ricci Katherine A. Fitzgerald The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans Nature Communications |
| title | The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans |
| title_full | The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans |
| title_fullStr | The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans |
| title_full_unstemmed | The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans |
| title_short | The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans |
| title_sort | long non coding rna lucat1 is a negative feedback regulator of interferon responses in humans |
| url | https://doi.org/10.1038/s41467-020-20165-5 |
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