Reduction of the Plasma Uric Acid Level in Potassium Oxoate-Induced Hyperuricemic Rats by Heat-Concentrated <i>Prunus mume</i> Fruit Extract Containing Three Chlorogenic Acid Isomers
Gout is a common rheumatic disease, resulting from hyperuricemia. <i>Prunus mume</i> fruit extract, after being heat-concentrated named mei extract, was empirically found to reduce the risk of gout. While neochlorogenic acid was found as the predominant phenolic compound in the fresh jui...
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MDPI AG
2023-02-01
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| Online Access: | https://www.mdpi.com/2673-6918/3/1/14 |
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| author | Yi-Ching Wu Ping-Chung Kuo Wen-Ying Chen Jason T. C. Tzen |
| author_facet | Yi-Ching Wu Ping-Chung Kuo Wen-Ying Chen Jason T. C. Tzen |
| author_sort | Yi-Ching Wu |
| collection | DOAJ |
| description | Gout is a common rheumatic disease, resulting from hyperuricemia. <i>Prunus mume</i> fruit extract, after being heat-concentrated named mei extract, was empirically found to reduce the risk of gout. While neochlorogenic acid was found as the predominant phenolic compound in the fresh juice of <i>Prunus mume</i>, neochlorogenic acid, chlorogenic acid, and cryptogenic acid were detected as the major phenolic compounds in the mei extract. In vitro testing showed that all the three chlorogenic acid isomers exhibited comparable inhibitory activities on xanthine oxidase. The hypouricemic effects of the mei extract were evaluated in potassium oxonate-induced hyperuricemic rats. Oral administrations of the mei extract significantly reduced the plasma uric acid level in hyperuricemic rats, but did not elevate the urinary uric acid level. The results provide in vivo evidence for the anti-hyperuricemic effects of mei extract for the first time, rationalize its therapeutic usage for the treatment of hyperuricemia and gout, and propose chlorogenic acid isomers as the active ingredients. Mei extract seems to be a potential natural functional food product. |
| first_indexed | 2024-03-11T06:43:28Z |
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| issn | 2673-6918 |
| language | English |
| last_indexed | 2024-03-11T06:43:28Z |
| publishDate | 2023-02-01 |
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| spelling | doaj.art-1d15e797edf04509ac300ab4d1a529752023-11-17T10:25:50ZengMDPI AGCompounds2673-69182023-02-013116917910.3390/compounds3010014Reduction of the Plasma Uric Acid Level in Potassium Oxoate-Induced Hyperuricemic Rats by Heat-Concentrated <i>Prunus mume</i> Fruit Extract Containing Three Chlorogenic Acid IsomersYi-Ching Wu0Ping-Chung Kuo1Wen-Ying Chen2Jason T. C. Tzen3Graduate Institute of Biotechnology, National Chung-Hsing University, Taichung 402, TaiwanSchool of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, TaiwanDepartment of Veterinary Medicine, National Chung-Hsing University, Taichung 402, TaiwanGraduate Institute of Biotechnology, National Chung-Hsing University, Taichung 402, TaiwanGout is a common rheumatic disease, resulting from hyperuricemia. <i>Prunus mume</i> fruit extract, after being heat-concentrated named mei extract, was empirically found to reduce the risk of gout. While neochlorogenic acid was found as the predominant phenolic compound in the fresh juice of <i>Prunus mume</i>, neochlorogenic acid, chlorogenic acid, and cryptogenic acid were detected as the major phenolic compounds in the mei extract. In vitro testing showed that all the three chlorogenic acid isomers exhibited comparable inhibitory activities on xanthine oxidase. The hypouricemic effects of the mei extract were evaluated in potassium oxonate-induced hyperuricemic rats. Oral administrations of the mei extract significantly reduced the plasma uric acid level in hyperuricemic rats, but did not elevate the urinary uric acid level. The results provide in vivo evidence for the anti-hyperuricemic effects of mei extract for the first time, rationalize its therapeutic usage for the treatment of hyperuricemia and gout, and propose chlorogenic acid isomers as the active ingredients. Mei extract seems to be a potential natural functional food product.https://www.mdpi.com/2673-6918/3/1/14chlorogenic acid isomerhyperuricemiamei extract<i>Prunus mume</i>xanthine oxidase |
| spellingShingle | Yi-Ching Wu Ping-Chung Kuo Wen-Ying Chen Jason T. C. Tzen Reduction of the Plasma Uric Acid Level in Potassium Oxoate-Induced Hyperuricemic Rats by Heat-Concentrated <i>Prunus mume</i> Fruit Extract Containing Three Chlorogenic Acid Isomers Compounds chlorogenic acid isomer hyperuricemia mei extract <i>Prunus mume</i> xanthine oxidase |
| title | Reduction of the Plasma Uric Acid Level in Potassium Oxoate-Induced Hyperuricemic Rats by Heat-Concentrated <i>Prunus mume</i> Fruit Extract Containing Three Chlorogenic Acid Isomers |
| title_full | Reduction of the Plasma Uric Acid Level in Potassium Oxoate-Induced Hyperuricemic Rats by Heat-Concentrated <i>Prunus mume</i> Fruit Extract Containing Three Chlorogenic Acid Isomers |
| title_fullStr | Reduction of the Plasma Uric Acid Level in Potassium Oxoate-Induced Hyperuricemic Rats by Heat-Concentrated <i>Prunus mume</i> Fruit Extract Containing Three Chlorogenic Acid Isomers |
| title_full_unstemmed | Reduction of the Plasma Uric Acid Level in Potassium Oxoate-Induced Hyperuricemic Rats by Heat-Concentrated <i>Prunus mume</i> Fruit Extract Containing Three Chlorogenic Acid Isomers |
| title_short | Reduction of the Plasma Uric Acid Level in Potassium Oxoate-Induced Hyperuricemic Rats by Heat-Concentrated <i>Prunus mume</i> Fruit Extract Containing Three Chlorogenic Acid Isomers |
| title_sort | reduction of the plasma uric acid level in potassium oxoate induced hyperuricemic rats by heat concentrated i prunus mume i fruit extract containing three chlorogenic acid isomers |
| topic | chlorogenic acid isomer hyperuricemia mei extract <i>Prunus mume</i> xanthine oxidase |
| url | https://www.mdpi.com/2673-6918/3/1/14 |
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