Triple-hit explanation for the worse prognosis of pediatric acute lymphoblastic leukemia among Mexican and Hispanic children
Acute lymphoblastic leukemia (ALL) is the most common malignancy among Mexican and Hispanic children and the first cause of death by disease in Mexico. We propose a “triple-hit” explanation for the survival gap affecting this population. The first hit can be attributed to epidemiology and social, cu...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1072811/full |
| _version_ | 1811321332040728576 |
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| author | Roberto Rivera-Luna Roberto Rivera-Luna Patricia Perez-Vera Cesar Galvan-Diaz Liliana Velasco-Hidalgo Alberto Olaya-Vargas Rocio Cardenas-Cardos Marco Aguilar-Ortiz Jesus Ponce-Cruz |
| author_facet | Roberto Rivera-Luna Roberto Rivera-Luna Patricia Perez-Vera Cesar Galvan-Diaz Liliana Velasco-Hidalgo Alberto Olaya-Vargas Rocio Cardenas-Cardos Marco Aguilar-Ortiz Jesus Ponce-Cruz |
| author_sort | Roberto Rivera-Luna |
| collection | DOAJ |
| description | Acute lymphoblastic leukemia (ALL) is the most common malignancy among Mexican and Hispanic children and the first cause of death by disease in Mexico. We propose a “triple-hit” explanation for the survival gap affecting this population. The first hit can be attributed to epidemiology and social, cultural, and economic burdens. The second hit refers to cancer biology, with a high incidence of unfavorable genetic characteristics associated with an unfavorable response to treatment and, subsequently, poor survival. Finally, the third hit relates to sub-optimal treatment and support. Society and culture, leukemia biology, and treatment approach limitations are key factors that should not be seen apart and must be considered comprehensively in any strategy to improve the prognosis of Mexican and Hispanic children with ALL. |
| first_indexed | 2024-04-13T13:14:50Z |
| format | Article |
| id | doaj.art-1d16f895b2c84c959352c389193e4c35 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-13T13:14:50Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-1d16f895b2c84c959352c389193e4c352022-12-22T02:45:29ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-11-011210.3389/fonc.2022.10728111072811Triple-hit explanation for the worse prognosis of pediatric acute lymphoblastic leukemia among Mexican and Hispanic childrenRoberto Rivera-Luna0Roberto Rivera-Luna1Patricia Perez-Vera2Cesar Galvan-Diaz3Liliana Velasco-Hidalgo4Alberto Olaya-Vargas5Rocio Cardenas-Cardos6Marco Aguilar-Ortiz7Jesus Ponce-Cruz8Department of Oncology, National Institute of Pediatrics, Mexico City, MexicoProgenitor and Hematopoietic Cell Transplant Unit, National Institute of Pediatrics, Mexico City, MexicoLaboratory of Genetics and Cancer, National Institute of Pediatrics, Mexico City, MexicoDepartment of Oncology, National Institute of Pediatrics, Mexico City, MexicoDepartment of Oncology, National Institute of Pediatrics, Mexico City, MexicoProgenitor and Hematopoietic Cell Transplant Unit, National Institute of Pediatrics, Mexico City, MexicoDepartment of Oncology, National Institute of Pediatrics, Mexico City, MexicoDepartment of Oncology, National Institute of Pediatrics, Mexico City, MexicoPediatric Oncology Unit, ABC Medical Center, Mexico City, MexicoAcute lymphoblastic leukemia (ALL) is the most common malignancy among Mexican and Hispanic children and the first cause of death by disease in Mexico. We propose a “triple-hit” explanation for the survival gap affecting this population. The first hit can be attributed to epidemiology and social, cultural, and economic burdens. The second hit refers to cancer biology, with a high incidence of unfavorable genetic characteristics associated with an unfavorable response to treatment and, subsequently, poor survival. Finally, the third hit relates to sub-optimal treatment and support. Society and culture, leukemia biology, and treatment approach limitations are key factors that should not be seen apart and must be considered comprehensively in any strategy to improve the prognosis of Mexican and Hispanic children with ALL.https://www.frontiersin.org/articles/10.3389/fonc.2022.1072811/fullacute lymphoblastic leukemiapediatricHispanicMexicansurvival gap |
| spellingShingle | Roberto Rivera-Luna Roberto Rivera-Luna Patricia Perez-Vera Cesar Galvan-Diaz Liliana Velasco-Hidalgo Alberto Olaya-Vargas Rocio Cardenas-Cardos Marco Aguilar-Ortiz Jesus Ponce-Cruz Triple-hit explanation for the worse prognosis of pediatric acute lymphoblastic leukemia among Mexican and Hispanic children Frontiers in Oncology acute lymphoblastic leukemia pediatric Hispanic Mexican survival gap |
| title | Triple-hit explanation for the worse prognosis of pediatric acute lymphoblastic leukemia among Mexican and Hispanic children |
| title_full | Triple-hit explanation for the worse prognosis of pediatric acute lymphoblastic leukemia among Mexican and Hispanic children |
| title_fullStr | Triple-hit explanation for the worse prognosis of pediatric acute lymphoblastic leukemia among Mexican and Hispanic children |
| title_full_unstemmed | Triple-hit explanation for the worse prognosis of pediatric acute lymphoblastic leukemia among Mexican and Hispanic children |
| title_short | Triple-hit explanation for the worse prognosis of pediatric acute lymphoblastic leukemia among Mexican and Hispanic children |
| title_sort | triple hit explanation for the worse prognosis of pediatric acute lymphoblastic leukemia among mexican and hispanic children |
| topic | acute lymphoblastic leukemia pediatric Hispanic Mexican survival gap |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1072811/full |
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