Visible and angular interrogation of Kretschmann-based SPR using hybrid Au–ZnO optical sensor for hyperuricemia detection
Uric acid is a waste product of the human body where high levels of it or hyperuricemia can lead to gout, kidney disease and other health issues. In this paper, Finite Difference Time Doman (FDTD) simulation method was used to develop a plasmonic optical sensor to detect uric acid with molarity rang...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023101344 |
| _version_ | 1827577443741859840 |
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| author | Siti Nasuha Mustaffa Nadhrah Md Yatim Affa Rozana Abdul Rashid Nadrah Md Yatim Vatsala Pithaih Nur Shahirah Sha'ari Ahmad Razif Muhammad Azaham Abdul Rahman Nur Akmar Jamil P. Susthitha Menon |
| author_facet | Siti Nasuha Mustaffa Nadhrah Md Yatim Affa Rozana Abdul Rashid Nadrah Md Yatim Vatsala Pithaih Nur Shahirah Sha'ari Ahmad Razif Muhammad Azaham Abdul Rahman Nur Akmar Jamil P. Susthitha Menon |
| author_sort | Siti Nasuha Mustaffa |
| collection | DOAJ |
| description | Uric acid is a waste product of the human body where high levels of it or hyperuricemia can lead to gout, kidney disease and other health issues. In this paper, Finite Difference Time Doman (FDTD) simulation method was used to develop a plasmonic optical sensor to detect uric acid with molarity ranging from 0 to 3.0 mM. A hybrid layer of gold-zinc oxide (Au–ZnO) was used in this Kretschmann-based Surface Plasmon Resonance (K-SPR) technique with angular interrogation at 670 nm and 785 nm visible optical wavelengths. The purpose of this study is to observe the ability of the hybrid material as a sensing performance enhancer for differentiating between healthy and unhealthy uric acid levels based on the refractive index values from previous study. Upon exposure to 670 nm wavelength, the average sensitivity of this sensor was found to be 0.028°/mM with a linearity of 98.67 % and Q-factor value of 0.0053 mM−1. While at 785 nm, the average sensitivity is equal to 0.0193°/mM with slightly lower linearity at 94.46 % and Q-factor value of 0.0076 mM−1. The results have proven the ability of hybrid material Au–ZnO as a sensing performance enhancer for detecting uric acid when compared with bare Au and can be further explored in experimental work. |
| first_indexed | 2024-03-08T21:27:53Z |
| format | Article |
| id | doaj.art-1d1746d2394746019e96b5e7a8405d34 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-08T21:27:53Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-1d1746d2394746019e96b5e7a8405d342023-12-21T07:35:10ZengElsevierHeliyon2405-84402023-12-01912e22926Visible and angular interrogation of Kretschmann-based SPR using hybrid Au–ZnO optical sensor for hyperuricemia detectionSiti Nasuha Mustaffa0Nadhrah Md Yatim1Affa Rozana Abdul Rashid2Nadrah Md Yatim3Vatsala Pithaih4Nur Shahirah Sha'ari5Ahmad Razif Muhammad6Azaham Abdul Rahman7Nur Akmar Jamil8P. Susthitha Menon9Institute of Microengineering and Nanoelectronics (IMEN), Universiti Kebangsaan Malaysia, 43600, UKM Bangi, Selangor, MalaysiaFaculty of Science and Technology, Universiti Sains Islam Malaysia (USIM), Bandar Baharu Nilai, 71800, Nilai, Negeri Sembilan, MalaysiaFaculty of Science and Technology, Universiti Sains Islam Malaysia (USIM), Bandar Baharu Nilai, 71800, Nilai, Negeri Sembilan, MalaysiaFaculty of Science and Technology, Universiti Sains Islam Malaysia (USIM), Bandar Baharu Nilai, 71800, Nilai, Negeri Sembilan, MalaysiaInstitute of Microengineering and Nanoelectronics (IMEN), Universiti Kebangsaan Malaysia, 43600, UKM Bangi, Selangor, MalaysiaFaculty of Science and Technology, Universiti Sains Islam Malaysia (USIM), Bandar Baharu Nilai, 71800, Nilai, Negeri Sembilan, MalaysiaInstitute of Microengineering and Nanoelectronics (IMEN), Universiti Kebangsaan Malaysia, 43600, UKM Bangi, Selangor, MalaysiaKulim Hi-Tech Pte Ltd, No.1, Jalan Bukit Hijau 26/24, Section 26, 40400, Shah Alam, Selangor, MalaysiaInstitute of Microengineering and Nanoelectronics (IMEN), Universiti Kebangsaan Malaysia, 43600, UKM Bangi, Selangor, MalaysiaInstitute of Microengineering and Nanoelectronics (IMEN), Universiti Kebangsaan Malaysia, 43600, UKM Bangi, Selangor, Malaysia; Corresponding author.Uric acid is a waste product of the human body where high levels of it or hyperuricemia can lead to gout, kidney disease and other health issues. In this paper, Finite Difference Time Doman (FDTD) simulation method was used to develop a plasmonic optical sensor to detect uric acid with molarity ranging from 0 to 3.0 mM. A hybrid layer of gold-zinc oxide (Au–ZnO) was used in this Kretschmann-based Surface Plasmon Resonance (K-SPR) technique with angular interrogation at 670 nm and 785 nm visible optical wavelengths. The purpose of this study is to observe the ability of the hybrid material as a sensing performance enhancer for differentiating between healthy and unhealthy uric acid levels based on the refractive index values from previous study. Upon exposure to 670 nm wavelength, the average sensitivity of this sensor was found to be 0.028°/mM with a linearity of 98.67 % and Q-factor value of 0.0053 mM−1. While at 785 nm, the average sensitivity is equal to 0.0193°/mM with slightly lower linearity at 94.46 % and Q-factor value of 0.0076 mM−1. The results have proven the ability of hybrid material Au–ZnO as a sensing performance enhancer for detecting uric acid when compared with bare Au and can be further explored in experimental work.http://www.sciencedirect.com/science/article/pii/S2405844023101344KretschmannSurface plasmon resonanceOptical sensorFDTD simulationUric acidZinc oxide |
| spellingShingle | Siti Nasuha Mustaffa Nadhrah Md Yatim Affa Rozana Abdul Rashid Nadrah Md Yatim Vatsala Pithaih Nur Shahirah Sha'ari Ahmad Razif Muhammad Azaham Abdul Rahman Nur Akmar Jamil P. Susthitha Menon Visible and angular interrogation of Kretschmann-based SPR using hybrid Au–ZnO optical sensor for hyperuricemia detection Heliyon Kretschmann Surface plasmon resonance Optical sensor FDTD simulation Uric acid Zinc oxide |
| title | Visible and angular interrogation of Kretschmann-based SPR using hybrid Au–ZnO optical sensor for hyperuricemia detection |
| title_full | Visible and angular interrogation of Kretschmann-based SPR using hybrid Au–ZnO optical sensor for hyperuricemia detection |
| title_fullStr | Visible and angular interrogation of Kretschmann-based SPR using hybrid Au–ZnO optical sensor for hyperuricemia detection |
| title_full_unstemmed | Visible and angular interrogation of Kretschmann-based SPR using hybrid Au–ZnO optical sensor for hyperuricemia detection |
| title_short | Visible and angular interrogation of Kretschmann-based SPR using hybrid Au–ZnO optical sensor for hyperuricemia detection |
| title_sort | visible and angular interrogation of kretschmann based spr using hybrid au zno optical sensor for hyperuricemia detection |
| topic | Kretschmann Surface plasmon resonance Optical sensor FDTD simulation Uric acid Zinc oxide |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023101344 |
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