The possible role of EBV in carcinogenesis of colorectal carcinoma.
Background: Except for the tight correlation to nasopharyngeal carcinoma, accumulating evidences show that Epstein-Barr virus (EBV) is correlated to other carcinomas. This study was to investigate the association of EBV with colorectal tumors. Materials & methods: Forty paraffin embedded blocks...
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| Format: | Article |
| Language: | English |
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College of Medicine University of Baghdad
2010-07-01
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| Series: | مجلة كلية الطب |
| Subjects: | |
| Online Access: | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1016 |
| _version_ | 1797330592130400256 |
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| author | Manal A. habib |
| author_facet | Manal A. habib |
| author_sort | Manal A. habib |
| collection | DOAJ |
| description | Background: Except for the tight correlation to nasopharyngeal carcinoma, accumulating evidences show that Epstein-Barr virus (EBV) is correlated to other carcinomas. This study was to investigate the association of EBV with colorectal tumors.
Materials & methods: Forty paraffin embedded blocks of colorectal tumors (thirty were adenocarcinoma and ten were benign tumors) were all examined for the presence of EBV DNA with
the application of In Situ hybridization.
Results: In Situ EBV DNA signals was detected in 6 out of 30 (20%) of colorectal carcinoma with no observed signals in the sections from benign group.
Conclusion: Our results showed that infection of EBV exists in human colorectal adenocarcinoma, which indicates that EBV may be involved in the carcinogenesis process. |
| first_indexed | 2024-03-08T07:22:03Z |
| format | Article |
| id | doaj.art-1d188af518964fa4b5a18bd3a4356992 |
| institution | Directory Open Access Journal |
| issn | 0041-9419 2410-8057 |
| language | English |
| last_indexed | 2024-03-08T07:22:03Z |
| publishDate | 2010-07-01 |
| publisher | College of Medicine University of Baghdad |
| record_format | Article |
| series | مجلة كلية الطب |
| spelling | doaj.art-1d188af518964fa4b5a18bd3a43569922024-02-02T22:55:11ZengCollege of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572010-07-0152210.32007/jfacmedbagdad.v2172-174%The possible role of EBV in carcinogenesis of colorectal carcinoma.Manal A. habib0Department of Pathology, College of Medicine, University of Baghdad.Background: Except for the tight correlation to nasopharyngeal carcinoma, accumulating evidences show that Epstein-Barr virus (EBV) is correlated to other carcinomas. This study was to investigate the association of EBV with colorectal tumors. Materials & methods: Forty paraffin embedded blocks of colorectal tumors (thirty were adenocarcinoma and ten were benign tumors) were all examined for the presence of EBV DNA with the application of In Situ hybridization. Results: In Situ EBV DNA signals was detected in 6 out of 30 (20%) of colorectal carcinoma with no observed signals in the sections from benign group. Conclusion: Our results showed that infection of EBV exists in human colorectal adenocarcinoma, which indicates that EBV may be involved in the carcinogenesis process.http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1016EBV, In Situ Hybridization, colorectal tumors. |
| spellingShingle | Manal A. habib The possible role of EBV in carcinogenesis of colorectal carcinoma. مجلة كلية الطب EBV, In Situ Hybridization, colorectal tumors. |
| title | The possible role of EBV in carcinogenesis of colorectal carcinoma. |
| title_full | The possible role of EBV in carcinogenesis of colorectal carcinoma. |
| title_fullStr | The possible role of EBV in carcinogenesis of colorectal carcinoma. |
| title_full_unstemmed | The possible role of EBV in carcinogenesis of colorectal carcinoma. |
| title_short | The possible role of EBV in carcinogenesis of colorectal carcinoma. |
| title_sort | possible role of ebv in carcinogenesis of colorectal carcinoma |
| topic | EBV, In Situ Hybridization, colorectal tumors. |
| url | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1016 |
| work_keys_str_mv | AT manalahabib thepossibleroleofebvincarcinogenesisofcolorectalcarcinoma AT manalahabib possibleroleofebvincarcinogenesisofcolorectalcarcinoma |