Myeloid lineage cells evince distinct steady-state level of certain gene groups in dependence on hereditary angioedema severity

Myeloid lineage cells evince distinct steady-state level of certain gene groups in dependence on hereditary angioedema severity

Hereditary angioedema (HAE) is a rare genetic disorder with variable expressivity even in carriers of the same underlying genetic defect, suggesting other genetic and epigenetic factors participate in modifying HAE severity. Recent knowledge indicates the role of immune cells in several aspects of H...

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Bibliographic Details
Main Authors: Lucie Ballonová, Přemysl Souček, Peter Slanina, Kamila Réblová, Ondřej Zapletal, Marcela Vlková, Roman Hakl, Viktor Bíly, Hana Grombiříková, Eliška Svobodová, Petra Kulíšková, Julie Štíchová, Marta Sobotková, Radana Zachová, Jana Hanzlíková, Martina Vachová, Pavlína Králíčková, Irena Krčmová, Miloš Jeseňák, Tomáš Freiberger
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Genetics
Subjects:
FXII
hereditary angioedema
immune cell
interferon-gamma
gene expression
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2023.1123914/full

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