Incidence and Progression of Coronary Artery Calcium in South Asians Compared With 4 Race/Ethnic Groups
Background South Asians have a relatively high prevalence of coronary artery calcium (CAC) compared with other race/ethnic groups. We determined CAC incidence and progression among South Asians, and compared them with 4 race/ethnic groups. Methods and Results Data from the MASALA (Mediators of Ather...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.118.011053 |
| _version_ | 1828878419357597696 |
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| author | Alka M. Kanaya Eric Vittinghoff Feng Lin Namratha R. Kandula David Herrington Kiang Liu Michael Blaha Matthew J. Budoff |
| author_facet | Alka M. Kanaya Eric Vittinghoff Feng Lin Namratha R. Kandula David Herrington Kiang Liu Michael Blaha Matthew J. Budoff |
| author_sort | Alka M. Kanaya |
| collection | DOAJ |
| description | Background South Asians have a relatively high prevalence of coronary artery calcium (CAC) compared with other race/ethnic groups. We determined CAC incidence and progression among South Asians, and compared them with 4 race/ethnic groups. Methods and Results Data from the MASALA (Mediators of Atherosclerosis in South Asians Living in America) study were used to calculate CAC incidence and progression rates and any CAC change. Data from the MESA (Multi‐Ethnic Study of Atherosclerosis) were used to compare the CAC incidence and progression rates. A total of 698 South Asians had repeat CAC measurements after 4.8±0.8 years. Among those with no CAC at baseline, the age‐adjusted CAC incidence was 8.8% (95% CI, 6.8–10.8%) in men and 3.6% (2.5–4.8%) in women. The median annual CAC progression was 26 (interquartile range, 11–62) for men and 13 (interquartile range, 4–34) for women. Compared with MESA, age‐adjusted CAC incidence was similar in South Asian men compared with white, black, and Latino men, but significantly higher than Chinese men (11.1% versus 5.7%, P=0.008). After adjusting for age, diabetes mellitus, hypertension, and statin medication use, Chinese, black, and Latino men had significantly less CAC change compared with South Asian men, but there were no differences between South Asian and white men. There was no difference in CAC incidence or progression between South Asian women and women in MESA. Conclusions South Asian men had greater CAC change than Chinese, black, and Latino men but similar change to that of whites after adjusting for traditional risk factors. |
| first_indexed | 2024-12-13T09:05:16Z |
| format | Article |
| id | doaj.art-1d1b9426ef9e42f08a8501848e007305 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-13T09:05:16Z |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-1d1b9426ef9e42f08a8501848e0073052022-12-21T23:53:05ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802019-01-018210.1161/JAHA.118.011053Incidence and Progression of Coronary Artery Calcium in South Asians Compared With 4 Race/Ethnic GroupsAlka M. Kanaya0Eric Vittinghoff1Feng Lin2Namratha R. Kandula3David Herrington4Kiang Liu5Michael Blaha6Matthew J. Budoff7University of California, San Francisco San Francisco USAUniversity of California, San Francisco San Francisco USAUniversity of California, San Francisco San Francisco USANorthwestern University Chicago USAWake Forest University Medical Center Winston‐Salem USANorthwestern University Chicago USAJohns Hopkins University Baltimore USALA Biomed Research Center Torrance USABackground South Asians have a relatively high prevalence of coronary artery calcium (CAC) compared with other race/ethnic groups. We determined CAC incidence and progression among South Asians, and compared them with 4 race/ethnic groups. Methods and Results Data from the MASALA (Mediators of Atherosclerosis in South Asians Living in America) study were used to calculate CAC incidence and progression rates and any CAC change. Data from the MESA (Multi‐Ethnic Study of Atherosclerosis) were used to compare the CAC incidence and progression rates. A total of 698 South Asians had repeat CAC measurements after 4.8±0.8 years. Among those with no CAC at baseline, the age‐adjusted CAC incidence was 8.8% (95% CI, 6.8–10.8%) in men and 3.6% (2.5–4.8%) in women. The median annual CAC progression was 26 (interquartile range, 11–62) for men and 13 (interquartile range, 4–34) for women. Compared with MESA, age‐adjusted CAC incidence was similar in South Asian men compared with white, black, and Latino men, but significantly higher than Chinese men (11.1% versus 5.7%, P=0.008). After adjusting for age, diabetes mellitus, hypertension, and statin medication use, Chinese, black, and Latino men had significantly less CAC change compared with South Asian men, but there were no differences between South Asian and white men. There was no difference in CAC incidence or progression between South Asian women and women in MESA. Conclusions South Asian men had greater CAC change than Chinese, black, and Latino men but similar change to that of whites after adjusting for traditional risk factors.https://www.ahajournals.org/doi/10.1161/JAHA.118.011053coronary artery calciumepidemiologyethnic differences |
| spellingShingle | Alka M. Kanaya Eric Vittinghoff Feng Lin Namratha R. Kandula David Herrington Kiang Liu Michael Blaha Matthew J. Budoff Incidence and Progression of Coronary Artery Calcium in South Asians Compared With 4 Race/Ethnic Groups Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease coronary artery calcium epidemiology ethnic differences |
| title | Incidence and Progression of Coronary Artery Calcium in South Asians Compared With 4 Race/Ethnic Groups |
| title_full | Incidence and Progression of Coronary Artery Calcium in South Asians Compared With 4 Race/Ethnic Groups |
| title_fullStr | Incidence and Progression of Coronary Artery Calcium in South Asians Compared With 4 Race/Ethnic Groups |
| title_full_unstemmed | Incidence and Progression of Coronary Artery Calcium in South Asians Compared With 4 Race/Ethnic Groups |
| title_short | Incidence and Progression of Coronary Artery Calcium in South Asians Compared With 4 Race/Ethnic Groups |
| title_sort | incidence and progression of coronary artery calcium in south asians compared with 4 race ethnic groups |
| topic | coronary artery calcium epidemiology ethnic differences |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.118.011053 |
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