Toward the Development of Epigenome Editing-Based Therapeutics: Potentials and Challenges
The advancement in epigenetics research over the past several decades has led to the potential application of epigenome-editing technologies for the treatment of various diseases. In particular, epigenome editing is potentially useful in the treatment of genetic and other related diseases, including...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/5/4778 |
| _version_ | 1797615138155528192 |
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| author | Jun Ueda Taiga Yamazaki Hiroshi Funakoshi |
| author_facet | Jun Ueda Taiga Yamazaki Hiroshi Funakoshi |
| author_sort | Jun Ueda |
| collection | DOAJ |
| description | The advancement in epigenetics research over the past several decades has led to the potential application of epigenome-editing technologies for the treatment of various diseases. In particular, epigenome editing is potentially useful in the treatment of genetic and other related diseases, including rare imprinted diseases, as it can regulate the expression of the epigenome of the target region, and thereby the causative gene, with minimal or no modification of the genomic DNA. Various efforts are underway to successfully apply epigenome editing in vivo, such as improving target specificity, enzymatic activity, and drug delivery for the development of reliable therapeutics. In this review, we introduce the latest findings, summarize the current limitations and future challenges in the practical application of epigenome editing for disease therapy, and introduce important factors to consider, such as chromatin plasticity, for a more effective epigenome editing-based therapy. |
| first_indexed | 2024-03-11T07:22:17Z |
| format | Article |
| id | doaj.art-1d1c3bbabc9e4fa69fcb8cc89e2d4b75 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T07:22:17Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-1d1c3bbabc9e4fa69fcb8cc89e2d4b752023-11-17T07:53:16ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-03-01245477810.3390/ijms24054778Toward the Development of Epigenome Editing-Based Therapeutics: Potentials and ChallengesJun Ueda0Taiga Yamazaki1Hiroshi Funakoshi2Department of Advanced Medical Science, Asahikawa Medical University, Asahikawa 078-8510, Hokkaido, JapanDivision of Biomedical Research, Kitasato University Medical Center, Kitasato University, 6-100 Arai, Kitamoto 364-8501, Saitama, JapanDepartment of Advanced Medical Science, Asahikawa Medical University, Asahikawa 078-8510, Hokkaido, JapanThe advancement in epigenetics research over the past several decades has led to the potential application of epigenome-editing technologies for the treatment of various diseases. In particular, epigenome editing is potentially useful in the treatment of genetic and other related diseases, including rare imprinted diseases, as it can regulate the expression of the epigenome of the target region, and thereby the causative gene, with minimal or no modification of the genomic DNA. Various efforts are underway to successfully apply epigenome editing in vivo, such as improving target specificity, enzymatic activity, and drug delivery for the development of reliable therapeutics. In this review, we introduce the latest findings, summarize the current limitations and future challenges in the practical application of epigenome editing for disease therapy, and introduce important factors to consider, such as chromatin plasticity, for a more effective epigenome editing-based therapy.https://www.mdpi.com/1422-0067/24/5/4778epigenome editingepigeneticschromatinchromatin plasticityin vivodrug delivery |
| spellingShingle | Jun Ueda Taiga Yamazaki Hiroshi Funakoshi Toward the Development of Epigenome Editing-Based Therapeutics: Potentials and Challenges International Journal of Molecular Sciences epigenome editing epigenetics chromatin chromatin plasticity in vivo drug delivery |
| title | Toward the Development of Epigenome Editing-Based Therapeutics: Potentials and Challenges |
| title_full | Toward the Development of Epigenome Editing-Based Therapeutics: Potentials and Challenges |
| title_fullStr | Toward the Development of Epigenome Editing-Based Therapeutics: Potentials and Challenges |
| title_full_unstemmed | Toward the Development of Epigenome Editing-Based Therapeutics: Potentials and Challenges |
| title_short | Toward the Development of Epigenome Editing-Based Therapeutics: Potentials and Challenges |
| title_sort | toward the development of epigenome editing based therapeutics potentials and challenges |
| topic | epigenome editing epigenetics chromatin chromatin plasticity in vivo drug delivery |
| url | https://www.mdpi.com/1422-0067/24/5/4778 |
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