Proximal tubular dysfunction as an indicator of chronic graft dysfunction
New strategies are being devised to limit the impact of renal sclerosis on graft function. Individualization of immunosuppression, specifically the interruption of calcineurin-inhibitors has been tried in order to promote better graft survival once chronic graft dysfunction has been established. How...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Associação Brasileira de Divulgação Científica
2009-03-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000300003 |
| _version_ | 1818110900191625216 |
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| author | N.O.S. Câmara W.W. Williams Jr. A. Pacheco-Silva |
| author_facet | N.O.S. Câmara W.W. Williams Jr. A. Pacheco-Silva |
| author_sort | N.O.S. Câmara |
| collection | DOAJ |
| description | New strategies are being devised to limit the impact of renal sclerosis on graft function. Individualization of immunosuppression, specifically the interruption of calcineurin-inhibitors has been tried in order to promote better graft survival once chronic graft dysfunction has been established. However, the long-term impact of these approaches is still not totally clear. Nevertheless, patients at higher risk for tubular atrophy and interstitial fibrosis (TA/IF) development should be carefully monitored for tubular function as well as glomerular performance. Since tubular-interstitial impairment is an early event in TA/IF pathogenesis and associated with graft function, it seems reasonable that strategies directed at assessing tubular structural integrity and function would yield important functional and prognostic data. The measurement of small proteins in urine such as α-1-microglobulin, N-acetyl-beta-D-glucosaminidase, alpha/pi S-glutathione transferases, β-2 microglobulin, and retinol binding protein is associated with proximal tubular cell dysfunction. Therefore, its straightforward assessment could provide a powerful tool in patient monitoring and ongoing clinical assessment of graft function, ultimately helping to facilitate longer patient and graft survival associated with good graft function. |
| first_indexed | 2024-12-11T02:54:29Z |
| format | Article |
| id | doaj.art-1d1c7ae91f1c4251ad19e6118917929b |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-12-11T02:54:29Z |
| publishDate | 2009-03-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-1d1c7ae91f1c4251ad19e6118917929b2022-12-22T01:23:12ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2009-03-01423229236Proximal tubular dysfunction as an indicator of chronic graft dysfunctionN.O.S. CâmaraW.W. Williams Jr.A. Pacheco-SilvaNew strategies are being devised to limit the impact of renal sclerosis on graft function. Individualization of immunosuppression, specifically the interruption of calcineurin-inhibitors has been tried in order to promote better graft survival once chronic graft dysfunction has been established. However, the long-term impact of these approaches is still not totally clear. Nevertheless, patients at higher risk for tubular atrophy and interstitial fibrosis (TA/IF) development should be carefully monitored for tubular function as well as glomerular performance. Since tubular-interstitial impairment is an early event in TA/IF pathogenesis and associated with graft function, it seems reasonable that strategies directed at assessing tubular structural integrity and function would yield important functional and prognostic data. The measurement of small proteins in urine such as α-1-microglobulin, N-acetyl-beta-D-glucosaminidase, alpha/pi S-glutathione transferases, β-2 microglobulin, and retinol binding protein is associated with proximal tubular cell dysfunction. Therefore, its straightforward assessment could provide a powerful tool in patient monitoring and ongoing clinical assessment of graft function, ultimately helping to facilitate longer patient and graft survival associated with good graft function.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000300003Renal transplantationTubular proteinsProximal tubular dysfunctionChronic allograft nephropathyRetinol binding protein |
| spellingShingle | N.O.S. Câmara W.W. Williams Jr. A. Pacheco-Silva Proximal tubular dysfunction as an indicator of chronic graft dysfunction Brazilian Journal of Medical and Biological Research Renal transplantation Tubular proteins Proximal tubular dysfunction Chronic allograft nephropathy Retinol binding protein |
| title | Proximal tubular dysfunction as an indicator of chronic graft dysfunction |
| title_full | Proximal tubular dysfunction as an indicator of chronic graft dysfunction |
| title_fullStr | Proximal tubular dysfunction as an indicator of chronic graft dysfunction |
| title_full_unstemmed | Proximal tubular dysfunction as an indicator of chronic graft dysfunction |
| title_short | Proximal tubular dysfunction as an indicator of chronic graft dysfunction |
| title_sort | proximal tubular dysfunction as an indicator of chronic graft dysfunction |
| topic | Renal transplantation Tubular proteins Proximal tubular dysfunction Chronic allograft nephropathy Retinol binding protein |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000300003 |
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