Topographic analysis of macular choriocapillaris flow deficits in diabetic retinopathy using swept–source optical coherence tomography angiography
Abstract Background The purpose of this study was to investigate the association between diabetic retinopathy (DR) severity and macular choriocapillaris (CC) flow deficit percentage (FD %) in different macular regions using swept-source optical coherence tomography angiography (SS-OCTA). Methods Dia...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-03-01
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| Series: | International Journal of Retina and Vitreous |
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| Online Access: | http://link.springer.com/article/10.1186/s40942-020-00209-0 |
| _version_ | 1818668325395234816 |
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| author | Isaac Gendelman A. Yasin Alibhai Eric M. Moult Emily S. Levine Phillip X. Braun Nihaal Mehta Yi Zhao Akihiro Ishibazawa Osama A. Sorour Caroline R. Baumal Andre J. Witkin Elias Reichel James G. Fujimoto Jay S. Duker Nadia K. Waheed |
| author_facet | Isaac Gendelman A. Yasin Alibhai Eric M. Moult Emily S. Levine Phillip X. Braun Nihaal Mehta Yi Zhao Akihiro Ishibazawa Osama A. Sorour Caroline R. Baumal Andre J. Witkin Elias Reichel James G. Fujimoto Jay S. Duker Nadia K. Waheed |
| author_sort | Isaac Gendelman |
| collection | DOAJ |
| description | Abstract Background The purpose of this study was to investigate the association between diabetic retinopathy (DR) severity and macular choriocapillaris (CC) flow deficit percentage (FD %) in different macular regions using swept-source optical coherence tomography angiography (SS-OCTA). Methods Diabetic patients with SS-OCTA images were graded by severity and retrospectively assessed. CC FD % was calculated in four different regions of the OCTA image: inner, middle, outer, and full-field region. The generalized estimating equations (GEE) approach for clustered eye data was used to determine effect size and significance of age and disease severity on FD % for each region. Results 160 eyes from 90 total diabetic patients met inclusion criteria. Out of 90 patients, 33 had no DR, 17 had mild nonproliferative DR (NPDR), 8 had moderate NPDR, 10 had severe NPDR and 22 had proliferative DR. Age and DR severity had a significant positive association with FD % for each region studied with a greater effect in the two centermost regions. The increase in flow deficit percentage per year of age by region was: inner 0.12 (p < 0.001), middle 0.09 (p < 0.001), outer 0.05 (p < 0.001, full-field 0.06 (p < 0.001). The increase in flow deficit percentage per increase in diabetic retinopathy severity stage by region was: inner 0.65 (p < 0.0087), middle 0.56 (p < 0.0012), outer 0.33 (p < 0.045), full-field 0.36 (p < 0.018). Conclusions Topographic analysis of the CC FD % in diabetic eyes suggests that CC flow impairment corresponds to DR severity, with all studied regions of the CC significantly affected. There was greater regional impairment due to age and disease severity in the inner and middle regions. |
| first_indexed | 2024-12-17T06:34:31Z |
| format | Article |
| id | doaj.art-1d1cd57c12b941baa4b37f8773c0e2b4 |
| institution | Directory Open Access Journal |
| issn | 2056-9920 |
| language | English |
| last_indexed | 2024-12-17T06:34:31Z |
| publishDate | 2020-03-01 |
| publisher | BMC |
| record_format | Article |
| series | International Journal of Retina and Vitreous |
| spelling | doaj.art-1d1cd57c12b941baa4b37f8773c0e2b42022-12-21T22:00:03ZengBMCInternational Journal of Retina and Vitreous2056-99202020-03-01611810.1186/s40942-020-00209-0Topographic analysis of macular choriocapillaris flow deficits in diabetic retinopathy using swept–source optical coherence tomography angiographyIsaac Gendelman0A. Yasin Alibhai1Eric M. Moult2Emily S. Levine3Phillip X. Braun4Nihaal Mehta5Yi Zhao6Akihiro Ishibazawa7Osama A. Sorour8Caroline R. Baumal9Andre J. Witkin10Elias Reichel11James G. Fujimoto12Jay S. Duker13Nadia K. Waheed14New England Eye Center, Tufts Medical CenterNew England Eye Center, Tufts Medical CenterDepartment Electrical Engineering and Computer Science, Massachusetts Institute of TechnologyNew England Eye Center, Tufts Medical CenterNew England Eye Center, Tufts Medical CenterNew England Eye Center, Tufts Medical CenterFriedman School of Nutrition Science and Policy, Tufts UniversityNew England Eye Center, Tufts Medical CenterNew England Eye Center, Tufts Medical CenterNew England Eye Center, Tufts Medical CenterNew England Eye Center, Tufts Medical CenterNew England Eye Center, Tufts Medical CenterDepartment Electrical Engineering and Computer Science, Massachusetts Institute of TechnologyNew England Eye Center, Tufts Medical CenterNew England Eye Center, Tufts Medical CenterAbstract Background The purpose of this study was to investigate the association between diabetic retinopathy (DR) severity and macular choriocapillaris (CC) flow deficit percentage (FD %) in different macular regions using swept-source optical coherence tomography angiography (SS-OCTA). Methods Diabetic patients with SS-OCTA images were graded by severity and retrospectively assessed. CC FD % was calculated in four different regions of the OCTA image: inner, middle, outer, and full-field region. The generalized estimating equations (GEE) approach for clustered eye data was used to determine effect size and significance of age and disease severity on FD % for each region. Results 160 eyes from 90 total diabetic patients met inclusion criteria. Out of 90 patients, 33 had no DR, 17 had mild nonproliferative DR (NPDR), 8 had moderate NPDR, 10 had severe NPDR and 22 had proliferative DR. Age and DR severity had a significant positive association with FD % for each region studied with a greater effect in the two centermost regions. The increase in flow deficit percentage per year of age by region was: inner 0.12 (p < 0.001), middle 0.09 (p < 0.001), outer 0.05 (p < 0.001, full-field 0.06 (p < 0.001). The increase in flow deficit percentage per increase in diabetic retinopathy severity stage by region was: inner 0.65 (p < 0.0087), middle 0.56 (p < 0.0012), outer 0.33 (p < 0.045), full-field 0.36 (p < 0.018). Conclusions Topographic analysis of the CC FD % in diabetic eyes suggests that CC flow impairment corresponds to DR severity, with all studied regions of the CC significantly affected. There was greater regional impairment due to age and disease severity in the inner and middle regions.http://link.springer.com/article/10.1186/s40942-020-00209-0ChoriocapillarisDiabetic retinopathyImagingOCT angiographyOphthalmologyRetina |
| spellingShingle | Isaac Gendelman A. Yasin Alibhai Eric M. Moult Emily S. Levine Phillip X. Braun Nihaal Mehta Yi Zhao Akihiro Ishibazawa Osama A. Sorour Caroline R. Baumal Andre J. Witkin Elias Reichel James G. Fujimoto Jay S. Duker Nadia K. Waheed Topographic analysis of macular choriocapillaris flow deficits in diabetic retinopathy using swept–source optical coherence tomography angiography International Journal of Retina and Vitreous Choriocapillaris Diabetic retinopathy Imaging OCT angiography Ophthalmology Retina |
| title | Topographic analysis of macular choriocapillaris flow deficits in diabetic retinopathy using swept–source optical coherence tomography angiography |
| title_full | Topographic analysis of macular choriocapillaris flow deficits in diabetic retinopathy using swept–source optical coherence tomography angiography |
| title_fullStr | Topographic analysis of macular choriocapillaris flow deficits in diabetic retinopathy using swept–source optical coherence tomography angiography |
| title_full_unstemmed | Topographic analysis of macular choriocapillaris flow deficits in diabetic retinopathy using swept–source optical coherence tomography angiography |
| title_short | Topographic analysis of macular choriocapillaris flow deficits in diabetic retinopathy using swept–source optical coherence tomography angiography |
| title_sort | topographic analysis of macular choriocapillaris flow deficits in diabetic retinopathy using swept source optical coherence tomography angiography |
| topic | Choriocapillaris Diabetic retinopathy Imaging OCT angiography Ophthalmology Retina |
| url | http://link.springer.com/article/10.1186/s40942-020-00209-0 |
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