Asthma and atopic dermatitis as risk factors for rheumatoid arthritis: a bidirectional mendelian randomization study
Abstract Background Previous observational studies have shown an association between asthma, atopic dermatitis (AD) and rheumatoid arthritis (RA). However, the bidirectional cause-effect chain between asthma and AD and RA has not been proven yet. Methods We performed bidirectional two-sample Mendeli...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-03-01
|
| Series: | BMC Medical Genomics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12920-023-01461-7 |
| _version_ | 1797863248153804800 |
|---|---|
| author | Chuiji Chen Le Su Wenhao Duan Yansen Zheng Dianzhong Zhang Yucai Wang |
| author_facet | Chuiji Chen Le Su Wenhao Duan Yansen Zheng Dianzhong Zhang Yucai Wang |
| author_sort | Chuiji Chen |
| collection | DOAJ |
| description | Abstract Background Previous observational studies have shown an association between asthma, atopic dermatitis (AD) and rheumatoid arthritis (RA). However, the bidirectional cause-effect chain between asthma and AD and RA has not been proven yet. Methods We performed bidirectional two-sample Mendelian randomization (TSMR) and selected single nucleotide polymorphisms (SNPs) associated with asthma, AD, and RA as instrumental variables. All of the SNPs were obtained from the latest genome-wide association study in Europeans. Inverse variance weighted (IVW) was the main method used in MR analysis. MR-Egger, weighted model, simple model, and weighted median were used for quality control. The robustness of the results was tested by sensitivity analysis. Results Asthma was found to be the largest effect size for RA susceptibility using the IVW method (OR, 1.35;95%CI, 1.13–1.60; P, 0.001), followed by AD (OR, 1.10;95%CI, 1.02–1.19; P, 0.019). In contrast, there was no causal relationship between RA and asthma (IVW: P = 0.673) or AD (IVW: P = 0.342). No pleiotropy or heterogeneity was found in the sensitivity analysis. Conclusion Findings from this study showed a causal relationship between genetic susceptibility to asthma or AD and increased risk of RA, but do not support a causal relationship between genetic susceptibility to RA and asthma or AD. |
| first_indexed | 2024-04-09T22:32:30Z |
| format | Article |
| id | doaj.art-1d1de7f6d69a4cc89588279995c09955 |
| institution | Directory Open Access Journal |
| issn | 1755-8794 |
| language | English |
| last_indexed | 2024-04-09T22:32:30Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Genomics |
| spelling | doaj.art-1d1de7f6d69a4cc89588279995c099552023-03-22T12:38:07ZengBMCBMC Medical Genomics1755-87942023-03-011611710.1186/s12920-023-01461-7Asthma and atopic dermatitis as risk factors for rheumatoid arthritis: a bidirectional mendelian randomization studyChuiji Chen0Le Su1Wenhao Duan2Yansen Zheng3Dianzhong Zhang4Yucai Wang5Department of Orthopedic Surgery, Tangdu Hospital, Fourth Military Medical UniversityDepartment of Orthopedic Surgery, The Fourth People’s Hospital of ZiboXi’an Medical UniversitySchool of Medicine, Yellow River Institute of Science and TechnologyDepartment of Orthopedic Surgery, Tangdu Hospital, Fourth Military Medical UniversityDepartment of Orthopedic Surgery, Tangdu Hospital, Fourth Military Medical UniversityAbstract Background Previous observational studies have shown an association between asthma, atopic dermatitis (AD) and rheumatoid arthritis (RA). However, the bidirectional cause-effect chain between asthma and AD and RA has not been proven yet. Methods We performed bidirectional two-sample Mendelian randomization (TSMR) and selected single nucleotide polymorphisms (SNPs) associated with asthma, AD, and RA as instrumental variables. All of the SNPs were obtained from the latest genome-wide association study in Europeans. Inverse variance weighted (IVW) was the main method used in MR analysis. MR-Egger, weighted model, simple model, and weighted median were used for quality control. The robustness of the results was tested by sensitivity analysis. Results Asthma was found to be the largest effect size for RA susceptibility using the IVW method (OR, 1.35;95%CI, 1.13–1.60; P, 0.001), followed by AD (OR, 1.10;95%CI, 1.02–1.19; P, 0.019). In contrast, there was no causal relationship between RA and asthma (IVW: P = 0.673) or AD (IVW: P = 0.342). No pleiotropy or heterogeneity was found in the sensitivity analysis. Conclusion Findings from this study showed a causal relationship between genetic susceptibility to asthma or AD and increased risk of RA, but do not support a causal relationship between genetic susceptibility to RA and asthma or AD.https://doi.org/10.1186/s12920-023-01461-7AsthmaAtopic dermatitisRheumatoid arthritisGeneticsMendelian randomization |
| spellingShingle | Chuiji Chen Le Su Wenhao Duan Yansen Zheng Dianzhong Zhang Yucai Wang Asthma and atopic dermatitis as risk factors for rheumatoid arthritis: a bidirectional mendelian randomization study BMC Medical Genomics Asthma Atopic dermatitis Rheumatoid arthritis Genetics Mendelian randomization |
| title | Asthma and atopic dermatitis as risk factors for rheumatoid arthritis: a bidirectional mendelian randomization study |
| title_full | Asthma and atopic dermatitis as risk factors for rheumatoid arthritis: a bidirectional mendelian randomization study |
| title_fullStr | Asthma and atopic dermatitis as risk factors for rheumatoid arthritis: a bidirectional mendelian randomization study |
| title_full_unstemmed | Asthma and atopic dermatitis as risk factors for rheumatoid arthritis: a bidirectional mendelian randomization study |
| title_short | Asthma and atopic dermatitis as risk factors for rheumatoid arthritis: a bidirectional mendelian randomization study |
| title_sort | asthma and atopic dermatitis as risk factors for rheumatoid arthritis a bidirectional mendelian randomization study |
| topic | Asthma Atopic dermatitis Rheumatoid arthritis Genetics Mendelian randomization |
| url | https://doi.org/10.1186/s12920-023-01461-7 |
| work_keys_str_mv | AT chuijichen asthmaandatopicdermatitisasriskfactorsforrheumatoidarthritisabidirectionalmendelianrandomizationstudy AT lesu asthmaandatopicdermatitisasriskfactorsforrheumatoidarthritisabidirectionalmendelianrandomizationstudy AT wenhaoduan asthmaandatopicdermatitisasriskfactorsforrheumatoidarthritisabidirectionalmendelianrandomizationstudy AT yansenzheng asthmaandatopicdermatitisasriskfactorsforrheumatoidarthritisabidirectionalmendelianrandomizationstudy AT dianzhongzhang asthmaandatopicdermatitisasriskfactorsforrheumatoidarthritisabidirectionalmendelianrandomizationstudy AT yucaiwang asthmaandatopicdermatitisasriskfactorsforrheumatoidarthritisabidirectionalmendelianrandomizationstudy |