A Neonatal Murine Escherichia coli Sepsis Model Demonstrates That Adjunctive Pentoxifylline Enhances the Ratio of Anti- vs. Pro-inflammatory Cytokines in Blood and Organ Tissues

A Neonatal Murine Escherichia coli Sepsis Model Demonstrates That Adjunctive Pentoxifylline Enhances the Ratio of Anti- vs. Pro-inflammatory Cytokines in Blood and Organ Tissues

Introduction: Neonatal sepsis triggers an inflammatory response that contributes to mortality and multiple organ injury. Pentoxifylline (PTX), a phosphodiesterase inhibitor which suppresses pro-inflammatory cytokines, is a candidate adjunctive therapy for newborn sepsis. We hypothesized that adminis...

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Bibliographic Details
Main Authors: Esther M. Speer, Elizabet Diago-Navarro, Lukasz S. Ozog, Mahnoor Raheel, Ofer Levy, Bettina C. Fries
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
newborn
sepsis
Escherichia coli
anti-inflammatory
pentoxifylline
interleukin 10
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.577878/full

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