Marital Status of Never Married with Rey Auditory Verbal Learning Test Cognition Performance Is Associated with Mild Cognitive Impairment
A small number of robust studies have explored the association between cognitive tests and marital status levels of mild cognitive impairment (MCI) patients using the TADPOLE dataset. Rey Auditory Verbal Learning Test (RAVLT) cognition performance combined with marital status levels is associated wi...
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MDPI AG
2023-01-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/13/3/1656 |
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| author | Yohn Jairo Parra Bautista Samia S. Messeha Carlos Theran Richard Aló Clement Yedjou Victor Adankai Samuel Babatunde on behalf of the Alzheimer’s Disease Prediction of Longitudinal Evolution (TADPOLE) |
| author_facet | Yohn Jairo Parra Bautista Samia S. Messeha Carlos Theran Richard Aló Clement Yedjou Victor Adankai Samuel Babatunde on behalf of the Alzheimer’s Disease Prediction of Longitudinal Evolution (TADPOLE) |
| author_sort | Yohn Jairo Parra Bautista |
| collection | DOAJ |
| description | A small number of robust studies have explored the association between cognitive tests and marital status levels of mild cognitive impairment (MCI) patients using the TADPOLE dataset. Rey Auditory Verbal Learning Test (RAVLT) cognition performance combined with marital status levels is associated with increased odds of MCI than either RAVLT in isolation. The cross-sectional association between RAVLT performance in immediate response, learning, forgetting, and perception of forgetting with marital status and MCI was evaluated using TADPOLE data. We included participants with MCI and normal cognition in our study. Based on our logistic regression model, four RAVLT subgroups are associated with MCI (low and high response performance, immediate response with learning, immediate response with learning and forgetting, immediate response with learning, forgetting, and perception of forgetting). We adjusted models for sex, age, race, marital status, education, ethnicity, APOE4 genotype, hippocampus, whole brain, ventricles, and ICV. A mean age of 77/67 years was observed in the sample (n = 6560), 44% of participants were females, and 58% had mild cognitive impairment. Subgroups whose ages are 61 to 70 (OR 0.26, 95% CI 0.15–0.45) and older (OR 0.07, 95% CI 0.04–0.12), as well as race: black/African American (OR 0.13, 95% CI 0.03–0.52), multiple races (OR 0.05, 95% CI 0.01–0.24), and never married (OR 0.2, 95% CI 0.12–0.34) were negatively associated with immediate response and forgetting subgroup tests. There is a need for studies that evaluate other cognitive tests in the TADPOLE dataset with missing data as a predictive tool that aligns with the factors associated with MCI. |
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| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-11T09:51:46Z |
| publishDate | 2023-01-01 |
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| series | Applied Sciences |
| spelling | doaj.art-1d1f6cc86e5d43118dd3decb4770f0b02023-11-16T16:08:36ZengMDPI AGApplied Sciences2076-34172023-01-01133165610.3390/app13031656Marital Status of Never Married with Rey Auditory Verbal Learning Test Cognition Performance Is Associated with Mild Cognitive ImpairmentYohn Jairo Parra Bautista0Samia S. Messeha1Carlos Theran2Richard Aló3Clement Yedjou4Victor Adankai5Samuel Babatunde6on behalf of the Alzheimer’s Disease Prediction of Longitudinal Evolution (TADPOLE)Department of Computer Information Sciences, College of Science and Technology, Florida A&M University, Tallahassee, FL 32307, USACollege of Pharmacy and Pharmaceutical Sciences, College of Science and Technology, Florida A&M University, Tallahassee, FL 32307, USADepartment of Computer Information Sciences, College of Science and Technology, Florida A&M University, Tallahassee, FL 32307, USADepartment of Computer Information Sciences, College of Science and Technology, Florida A&M University, Tallahassee, FL 32307, USADepartment of Biological Sciences, College of Science and Technology, Florida A&M University, Tallahassee, FL 32307, USADepartment of Computer Information Sciences, College of Science and Technology, Florida A&M University, Tallahassee, FL 32307, USADepartment of Computer Information Sciences, College of Science and Technology, Florida A&M University, Tallahassee, FL 32307, USAA small number of robust studies have explored the association between cognitive tests and marital status levels of mild cognitive impairment (MCI) patients using the TADPOLE dataset. Rey Auditory Verbal Learning Test (RAVLT) cognition performance combined with marital status levels is associated with increased odds of MCI than either RAVLT in isolation. The cross-sectional association between RAVLT performance in immediate response, learning, forgetting, and perception of forgetting with marital status and MCI was evaluated using TADPOLE data. We included participants with MCI and normal cognition in our study. Based on our logistic regression model, four RAVLT subgroups are associated with MCI (low and high response performance, immediate response with learning, immediate response with learning and forgetting, immediate response with learning, forgetting, and perception of forgetting). We adjusted models for sex, age, race, marital status, education, ethnicity, APOE4 genotype, hippocampus, whole brain, ventricles, and ICV. A mean age of 77/67 years was observed in the sample (n = 6560), 44% of participants were females, and 58% had mild cognitive impairment. Subgroups whose ages are 61 to 70 (OR 0.26, 95% CI 0.15–0.45) and older (OR 0.07, 95% CI 0.04–0.12), as well as race: black/African American (OR 0.13, 95% CI 0.03–0.52), multiple races (OR 0.05, 95% CI 0.01–0.24), and never married (OR 0.2, 95% CI 0.12–0.34) were negatively associated with immediate response and forgetting subgroup tests. There is a need for studies that evaluate other cognitive tests in the TADPOLE dataset with missing data as a predictive tool that aligns with the factors associated with MCI.https://www.mdpi.com/2076-3417/13/3/1656cognitive testeducationcognitive impairmentdementia |
| spellingShingle | Yohn Jairo Parra Bautista Samia S. Messeha Carlos Theran Richard Aló Clement Yedjou Victor Adankai Samuel Babatunde on behalf of the Alzheimer’s Disease Prediction of Longitudinal Evolution (TADPOLE) Marital Status of Never Married with Rey Auditory Verbal Learning Test Cognition Performance Is Associated with Mild Cognitive Impairment Applied Sciences cognitive test education cognitive impairment dementia |
| title | Marital Status of Never Married with Rey Auditory Verbal Learning Test Cognition Performance Is Associated with Mild Cognitive Impairment |
| title_full | Marital Status of Never Married with Rey Auditory Verbal Learning Test Cognition Performance Is Associated with Mild Cognitive Impairment |
| title_fullStr | Marital Status of Never Married with Rey Auditory Verbal Learning Test Cognition Performance Is Associated with Mild Cognitive Impairment |
| title_full_unstemmed | Marital Status of Never Married with Rey Auditory Verbal Learning Test Cognition Performance Is Associated with Mild Cognitive Impairment |
| title_short | Marital Status of Never Married with Rey Auditory Verbal Learning Test Cognition Performance Is Associated with Mild Cognitive Impairment |
| title_sort | marital status of never married with rey auditory verbal learning test cognition performance is associated with mild cognitive impairment |
| topic | cognitive test education cognitive impairment dementia |
| url | https://www.mdpi.com/2076-3417/13/3/1656 |
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