A Machine Learning Model to Predict Knee Osteoarthritis Cartilage Volume Changes over Time Using Baseline Bone Curvature
The hallmark of osteoarthritis (OA), the most prevalent musculoskeletal disease, is the loss of cartilage. By using machine learning (ML), we aimed to assess if baseline knee bone curvature (BC) could predict cartilage volume loss (CVL) at one year, and to develop a gender-based model. BC and cartil...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/6/1247 |
| _version_ | 1797489780168065024 |
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| author | Hossein Bonakdari Jean-Pierre Pelletier François Abram Johanne Martel-Pelletier |
| author_facet | Hossein Bonakdari Jean-Pierre Pelletier François Abram Johanne Martel-Pelletier |
| author_sort | Hossein Bonakdari |
| collection | DOAJ |
| description | The hallmark of osteoarthritis (OA), the most prevalent musculoskeletal disease, is the loss of cartilage. By using machine learning (ML), we aimed to assess if baseline knee bone curvature (BC) could predict cartilage volume loss (CVL) at one year, and to develop a gender-based model. BC and cartilage volume were assessed on 1246 participants using magnetic resonance imaging. Variables included age, body mass index, and baseline values of eight BC regions. The outcome consisted of CVL at one year in 12 regions. Five ML methods were evaluated. Validation demonstrated very good accuracy for both genders (R ≥ 0.78), except the medial tibial plateau for the woman. In conclusion, we demonstrated, for the first time, that knee CVL at one year could be predicted using five baseline BC region values. This would benefit patients at risk of structural progressive knee OA. |
| first_indexed | 2024-03-10T00:21:30Z |
| format | Article |
| id | doaj.art-1d213a324a5f45a2884c8309a8da25b1 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T00:21:30Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-1d213a324a5f45a2884c8309a8da25b12023-11-23T15:41:30ZengMDPI AGBiomedicines2227-90592022-05-01106124710.3390/biomedicines10061247A Machine Learning Model to Predict Knee Osteoarthritis Cartilage Volume Changes over Time Using Baseline Bone CurvatureHossein Bonakdari0Jean-Pierre Pelletier1François Abram2Johanne Martel-Pelletier3Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC H2X 0A9, CanadaOsteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC H2X 0A9, CanadaMedical Imaging Consultant, ArthroLab Inc., Montreal, QC H2X 0A9, CanadaOsteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC H2X 0A9, CanadaThe hallmark of osteoarthritis (OA), the most prevalent musculoskeletal disease, is the loss of cartilage. By using machine learning (ML), we aimed to assess if baseline knee bone curvature (BC) could predict cartilage volume loss (CVL) at one year, and to develop a gender-based model. BC and cartilage volume were assessed on 1246 participants using magnetic resonance imaging. Variables included age, body mass index, and baseline values of eight BC regions. The outcome consisted of CVL at one year in 12 regions. Five ML methods were evaluated. Validation demonstrated very good accuracy for both genders (R ≥ 0.78), except the medial tibial plateau for the woman. In conclusion, we demonstrated, for the first time, that knee CVL at one year could be predicted using five baseline BC region values. This would benefit patients at risk of structural progressive knee OA.https://www.mdpi.com/2227-9059/10/6/1247cartilage volume lossbone curvatureosteoarthritispredictionmachine learning |
| spellingShingle | Hossein Bonakdari Jean-Pierre Pelletier François Abram Johanne Martel-Pelletier A Machine Learning Model to Predict Knee Osteoarthritis Cartilage Volume Changes over Time Using Baseline Bone Curvature Biomedicines cartilage volume loss bone curvature osteoarthritis prediction machine learning |
| title | A Machine Learning Model to Predict Knee Osteoarthritis Cartilage Volume Changes over Time Using Baseline Bone Curvature |
| title_full | A Machine Learning Model to Predict Knee Osteoarthritis Cartilage Volume Changes over Time Using Baseline Bone Curvature |
| title_fullStr | A Machine Learning Model to Predict Knee Osteoarthritis Cartilage Volume Changes over Time Using Baseline Bone Curvature |
| title_full_unstemmed | A Machine Learning Model to Predict Knee Osteoarthritis Cartilage Volume Changes over Time Using Baseline Bone Curvature |
| title_short | A Machine Learning Model to Predict Knee Osteoarthritis Cartilage Volume Changes over Time Using Baseline Bone Curvature |
| title_sort | machine learning model to predict knee osteoarthritis cartilage volume changes over time using baseline bone curvature |
| topic | cartilage volume loss bone curvature osteoarthritis prediction machine learning |
| url | https://www.mdpi.com/2227-9059/10/6/1247 |
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