Colchicine for the treatment of COVID-19: short path from theory to practice
Colchicine is an alkaloid isolated from plants of the Colchicum genus. Colchicine has been used for thousands of years and remains one of the few drugs whose use remains relevant today. The therapeutic use of colchicine is widely known for gout, familial Mediterranean fever, Behcet’s disease, cardio...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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Remedium Group LLC
2022-07-01
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| Series: | Медицинский совет |
| Subjects: | |
| Online Access: | https://www.med-sovet.pro/jour/article/view/6958 |
| _version_ | 1797841479790493696 |
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| author | M. S. Eliseev O. V. Zheliabina |
| author_facet | M. S. Eliseev O. V. Zheliabina |
| author_sort | M. S. Eliseev |
| collection | DOAJ |
| description | Colchicine is an alkaloid isolated from plants of the Colchicum genus. Colchicine has been used for thousands of years and remains one of the few drugs whose use remains relevant today. The therapeutic use of colchicine is widely known for gout, familial Mediterranean fever, Behcet’s disease, cardiovascular diseases (pericarditis, coronary heart disease, pericarditis, after coronary artery bypass grafting, etc.) and other diseases and is due to anti-inflammatory effects, which are based, including , inhibition of NLRP3 inflammasome and interleukin (IL)-1β production. The mechanisms of anti-inflammatory action of colchicine are diverse. It is primarily an inhibitor of mitosis and microtubule assembly. Colchicine destroys the structure of microtubules and reduces the elasticity and relaxation of neutrophils, thereby preventing the extravasation of neutrophils from blood vessels to the site of inflammation. Systemic inflammation is also a hallmark of coronavirus disease (COVID-19), which develops immunological disorders accompanied by the production of a large number of pro-inflammatory cytokines, including interleukin-1. Coronavirus disease 2019 (COVID-19), which has become the most urgent medical problem in the world in the last 2 years, given the mechanisms of inflammation similar to rheumatic diseases, is also considered a disease with the potential effectiveness of colchicine treatment. SARS-CoV-2 vaccines also have a trigger factor for the development of an exacerbation of arthritis. On average, colchicine use was associated with a 47% reduction in post-vaccination arthritis. This article provides an update on the mechanisms of action and current experience with colchicine in COVID-19, including in patients with microcrystalline arthritis. |
| first_indexed | 2024-04-09T16:31:33Z |
| format | Article |
| id | doaj.art-1d22ea9988be40e38da9a907a897f931 |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:31:33Z |
| publishDate | 2022-07-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-1d22ea9988be40e38da9a907a897f9312023-04-23T06:57:03ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902022-07-01011717910.21518/2079-701X-2022-16-11-71-796232Colchicine for the treatment of COVID-19: short path from theory to practiceM. S. Eliseev0O. V. Zheliabina1Nasonova Research Institute of RheumatologyNasonova Research Institute of RheumatologyColchicine is an alkaloid isolated from plants of the Colchicum genus. Colchicine has been used for thousands of years and remains one of the few drugs whose use remains relevant today. The therapeutic use of colchicine is widely known for gout, familial Mediterranean fever, Behcet’s disease, cardiovascular diseases (pericarditis, coronary heart disease, pericarditis, after coronary artery bypass grafting, etc.) and other diseases and is due to anti-inflammatory effects, which are based, including , inhibition of NLRP3 inflammasome and interleukin (IL)-1β production. The mechanisms of anti-inflammatory action of colchicine are diverse. It is primarily an inhibitor of mitosis and microtubule assembly. Colchicine destroys the structure of microtubules and reduces the elasticity and relaxation of neutrophils, thereby preventing the extravasation of neutrophils from blood vessels to the site of inflammation. Systemic inflammation is also a hallmark of coronavirus disease (COVID-19), which develops immunological disorders accompanied by the production of a large number of pro-inflammatory cytokines, including interleukin-1. Coronavirus disease 2019 (COVID-19), which has become the most urgent medical problem in the world in the last 2 years, given the mechanisms of inflammation similar to rheumatic diseases, is also considered a disease with the potential effectiveness of colchicine treatment. SARS-CoV-2 vaccines also have a trigger factor for the development of an exacerbation of arthritis. On average, colchicine use was associated with a 47% reduction in post-vaccination arthritis. This article provides an update on the mechanisms of action and current experience with colchicine in COVID-19, including in patients with microcrystalline arthritis.https://www.med-sovet.pro/jour/article/view/6958colchicinemechanism of actioninflammationpharmacokineticscovid-19gout |
| spellingShingle | M. S. Eliseev O. V. Zheliabina Colchicine for the treatment of COVID-19: short path from theory to practice Медицинский совет colchicine mechanism of action inflammation pharmacokinetics covid-19 gout |
| title | Colchicine for the treatment of COVID-19: short path from theory to practice |
| title_full | Colchicine for the treatment of COVID-19: short path from theory to practice |
| title_fullStr | Colchicine for the treatment of COVID-19: short path from theory to practice |
| title_full_unstemmed | Colchicine for the treatment of COVID-19: short path from theory to practice |
| title_short | Colchicine for the treatment of COVID-19: short path from theory to practice |
| title_sort | colchicine for the treatment of covid 19 short path from theory to practice |
| topic | colchicine mechanism of action inflammation pharmacokinetics covid-19 gout |
| url | https://www.med-sovet.pro/jour/article/view/6958 |
| work_keys_str_mv | AT mseliseev colchicineforthetreatmentofcovid19shortpathfromtheorytopractice AT ovzheliabina colchicineforthetreatmentofcovid19shortpathfromtheorytopractice |