Wss1 metalloprotease partners with Cdc48/Doa1 in processing genotoxic SUMO conjugates

Wss1 metalloprotease partners with Cdc48/Doa1 in processing genotoxic SUMO conjugates

Sumoylation during genotoxic stress regulates the composition of DNA repair complexes. The yeast metalloprotease Wss1 clears chromatin-bound sumoylated proteins. Wss1 and its mammalian analog, DVC1/Spartan, belong to minigluzincins family of proteases. Wss1 proteolytic activity is regulated by a cys...

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Bibliographic Details
Main Authors: Maxim Y Balakirev, James E Mullally, Adrien Favier, Nicole Assard, Eric Sulpice, David F Lindsey, Anastasia V Rulina, Xavier Gidrol, Keith D Wilkinson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-09-01
Series:eLife
Subjects:
SUMO metabolism
DNA repair
poly SUMO
Cdc48
Doa1
vacuole
Online Access:https://elifesciences.org/articles/06763

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