Persistent Colonization of Ciprofloxacin-Resistant and Extended-Spectrum β-Lactamase (ESBL)-Producing Salmonella enterica Serovar Kentucky ST198 in a Patient with Inflammatory Bowel Disease
Yue Jiang,1,2,* Huilin Yang,3,* Zhen-Yu Wang,1,2 Da-Chuan Lin,4 Xinan Jiao,1,2 Yunlong Hu,3,4 Jing Wang1,2 1Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou, 225009, People’s Republic of China; 2Key Laboratory of Prevention and Control of Biological Hazard Factors (A...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2024-04-01
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| Series: | Infection and Drug Resistance |
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| Online Access: | https://www.dovepress.com/persistent-colonization-of-ciprofloxacin-resistant-and-extended-spectr-peer-reviewed-fulltext-article-IDR |
| _version_ | 1797208903294910464 |
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| author | Jiang Y Yang H Wang ZY Lin DC Jiao X Hu Y Wang J |
| author_facet | Jiang Y Yang H Wang ZY Lin DC Jiao X Hu Y Wang J |
| author_sort | Jiang Y |
| collection | DOAJ |
| description | Yue Jiang,1,2,* Huilin Yang,3,* Zhen-Yu Wang,1,2 Da-Chuan Lin,4 Xinan Jiao,1,2 Yunlong Hu,3,4 Jing Wang1,2 1Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou, 225009, People’s Republic of China; 2Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture of China, Yangzhou University, Yangzhou, 225009, People’s Republic of China; 3Department of Clinical Laboratory, Peking University Shenzhen Hospital, Shenzhen, 518036, People’s Republic of China; 4Guangdong Key Laboratory of Regional Immunity and Diseases, Shenzhen University School of Medicine, Shenzhen University, Shenzhen, 518060, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yunlong Hu; Jing Wang, Email huyunlong@pkuszh.com; wj1231@yzu.edu.cnObjective: Salmonella enterica serovar Kentucky ST198 has emerged as a global threat to humans. In this study, we aimed to characterize the prolonged carriage of ciprofloxacin-resistant and extended-spectrum β-lactamase (ESBL)-producing S. Kentucky ST198 in a single patient with inflammatory bowel disease (IBD).Methods: Three S. Kentucky strains were collected from a single patient with IBD on 11th January, 23rd January, and 8th February, 2022, respectively. Antimicrobial susceptibility testing, whole-genome sequencing, and phylogenetic analysis with 38 previously described Chinese S. Kentucky ST198 strains from patients and food were performed.Results: All three S. Kentucky isolates belonged to ST198. They carried identical 16 resistance genes, such as blaCTX-M-55, tet(A), and qnrS1, and had identical mutations within gyrA (S83F and D87N) and parC (S80I). Therefore, they exhibited identical multidrug-resistant profiles, including the clinically important antibiotics cephalosporins (ceftazidime and cefepime), fluoroquinolones (ciprofloxacin and levofloxacin), and third-generation tetracycline (tigecycline). Our three S. Kentucky strains were classified into the subclade ST198.2– 2, and were genetically identical (2– 6 SNPs) to each other. They exhibited a close genetic similarity (15– 20 SNPs) to the isolate NT-h3189 from a patient and AH19MCS1 from chicken meat in China, indicating a possible epidemiological link between these S. Kentucky ST198 isolates from the patients and chicken meat.Conclusion: Long-term colonization of ciprofloxacin-resistant and ESBL-producing S. Kentucky ST198 in a single patient is a matter of concern. Due to the potential transfer of S. Kentucky ST198 from food sources to humans, ongoing surveillance of this particular clone in animals, animal-derived food products, and humans should be strengthened.Keywords: Salmonella, MDR, Kentucky, persistent colonization |
| first_indexed | 2024-04-24T09:46:12Z |
| format | Article |
| id | doaj.art-1d24f0f5dca948019d92ca6883dc3814 |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-04-24T09:46:12Z |
| publishDate | 2024-04-01 |
| publisher | Dove Medical Press |
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| series | Infection and Drug Resistance |
| spelling | doaj.art-1d24f0f5dca948019d92ca6883dc38142024-04-14T19:52:36ZengDove Medical PressInfection and Drug Resistance1178-69732024-04-01Volume 171459146691938Persistent Colonization of Ciprofloxacin-Resistant and Extended-Spectrum β-Lactamase (ESBL)-Producing Salmonella enterica Serovar Kentucky ST198 in a Patient with Inflammatory Bowel DiseaseJiang YYang HWang ZYLin DCJiao XHu YWang JYue Jiang,1,2,* Huilin Yang,3,* Zhen-Yu Wang,1,2 Da-Chuan Lin,4 Xinan Jiao,1,2 Yunlong Hu,3,4 Jing Wang1,2 1Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou, 225009, People’s Republic of China; 2Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture of China, Yangzhou University, Yangzhou, 225009, People’s Republic of China; 3Department of Clinical Laboratory, Peking University Shenzhen Hospital, Shenzhen, 518036, People’s Republic of China; 4Guangdong Key Laboratory of Regional Immunity and Diseases, Shenzhen University School of Medicine, Shenzhen University, Shenzhen, 518060, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yunlong Hu; Jing Wang, Email huyunlong@pkuszh.com; wj1231@yzu.edu.cnObjective: Salmonella enterica serovar Kentucky ST198 has emerged as a global threat to humans. In this study, we aimed to characterize the prolonged carriage of ciprofloxacin-resistant and extended-spectrum β-lactamase (ESBL)-producing S. Kentucky ST198 in a single patient with inflammatory bowel disease (IBD).Methods: Three S. Kentucky strains were collected from a single patient with IBD on 11th January, 23rd January, and 8th February, 2022, respectively. Antimicrobial susceptibility testing, whole-genome sequencing, and phylogenetic analysis with 38 previously described Chinese S. Kentucky ST198 strains from patients and food were performed.Results: All three S. Kentucky isolates belonged to ST198. They carried identical 16 resistance genes, such as blaCTX-M-55, tet(A), and qnrS1, and had identical mutations within gyrA (S83F and D87N) and parC (S80I). Therefore, they exhibited identical multidrug-resistant profiles, including the clinically important antibiotics cephalosporins (ceftazidime and cefepime), fluoroquinolones (ciprofloxacin and levofloxacin), and third-generation tetracycline (tigecycline). Our three S. Kentucky strains were classified into the subclade ST198.2– 2, and were genetically identical (2– 6 SNPs) to each other. They exhibited a close genetic similarity (15– 20 SNPs) to the isolate NT-h3189 from a patient and AH19MCS1 from chicken meat in China, indicating a possible epidemiological link between these S. Kentucky ST198 isolates from the patients and chicken meat.Conclusion: Long-term colonization of ciprofloxacin-resistant and ESBL-producing S. Kentucky ST198 in a single patient is a matter of concern. Due to the potential transfer of S. Kentucky ST198 from food sources to humans, ongoing surveillance of this particular clone in animals, animal-derived food products, and humans should be strengthened.Keywords: Salmonella, MDR, Kentucky, persistent colonizationhttps://www.dovepress.com/persistent-colonization-of-ciprofloxacin-resistant-and-extended-spectr-peer-reviewed-fulltext-article-IDRsalmonellamdrkentuckypersistent colonization |
| spellingShingle | Jiang Y Yang H Wang ZY Lin DC Jiao X Hu Y Wang J Persistent Colonization of Ciprofloxacin-Resistant and Extended-Spectrum β-Lactamase (ESBL)-Producing Salmonella enterica Serovar Kentucky ST198 in a Patient with Inflammatory Bowel Disease Infection and Drug Resistance salmonella mdr kentucky persistent colonization |
| title | Persistent Colonization of Ciprofloxacin-Resistant and Extended-Spectrum β-Lactamase (ESBL)-Producing Salmonella enterica Serovar Kentucky ST198 in a Patient with Inflammatory Bowel Disease |
| title_full | Persistent Colonization of Ciprofloxacin-Resistant and Extended-Spectrum β-Lactamase (ESBL)-Producing Salmonella enterica Serovar Kentucky ST198 in a Patient with Inflammatory Bowel Disease |
| title_fullStr | Persistent Colonization of Ciprofloxacin-Resistant and Extended-Spectrum β-Lactamase (ESBL)-Producing Salmonella enterica Serovar Kentucky ST198 in a Patient with Inflammatory Bowel Disease |
| title_full_unstemmed | Persistent Colonization of Ciprofloxacin-Resistant and Extended-Spectrum β-Lactamase (ESBL)-Producing Salmonella enterica Serovar Kentucky ST198 in a Patient with Inflammatory Bowel Disease |
| title_short | Persistent Colonization of Ciprofloxacin-Resistant and Extended-Spectrum β-Lactamase (ESBL)-Producing Salmonella enterica Serovar Kentucky ST198 in a Patient with Inflammatory Bowel Disease |
| title_sort | persistent colonization of ciprofloxacin resistant and extended spectrum beta lactamase esbl producing salmonella enterica serovar kentucky st198 in a patient with inflammatory bowel disease |
| topic | salmonella mdr kentucky persistent colonization |
| url | https://www.dovepress.com/persistent-colonization-of-ciprofloxacin-resistant-and-extended-spectr-peer-reviewed-fulltext-article-IDR |
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