Impact of Curcumin (with or without Piperine) on the Pharmacokinetics of Tamoxifen

Impact of Curcumin (with or without Piperine) on the Pharmacokinetics of Tamoxifen

Tamoxifen is a prodrug that is primarily metabolized into the pharmacologically active metabolite endoxifen and eventually into inactive metabolites. The herb curcumin may increase endoxifen exposure by affecting phase II metabolism. We compared endoxifen and tamoxifen exposure in breast cancer pati...

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Bibliographic Details
Main Authors: Koen G.A.M. Hussaarts, Daan P. Hurkmans, Esther Oomen-de Hoop, Leonie J. van Harten, Stan Berghuis, Robbert J. van Alphen, Leontine E.A. Spierings, Quirine C. van Rossum-Schornagel, Mijntje B. Vastbinder, Ron H.N. van Schaik, Teun van Gelder, Agnes Jager, Roelof W.F. van Leeuwen, Ron H.J. Mathijssen
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Cancers
Subjects:
tamoxifen
curcumin
piperine
pharmacokinetics
drug interactions
Online Access:https://www.mdpi.com/2072-6694/11/3/403

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