Autologous and micro-fragmented adipose tissue for the treatment of diffuse degenerative knee osteoarthritis
Abstract Background Chondral lesions of the knee represent a challenge for the orthopaedic surgeon. Several treatments have been proposed with variable success rate. Recently, new therapeutic approaches, such as the use of mesenchymal stem cells, have shown promising results. The adipose tissue is a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-10-01
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| Series: | Journal of Experimental Orthopaedics |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40634-017-0108-2 |
| _version_ | 1827266540629655552 |
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| author | A. Russo V. Condello V. Madonna M. Guerriero C. Zorzi |
| author_facet | A. Russo V. Condello V. Madonna M. Guerriero C. Zorzi |
| author_sort | A. Russo |
| collection | DOAJ |
| description | Abstract Background Chondral lesions of the knee represent a challenge for the orthopaedic surgeon. Several treatments have been proposed with variable success rate. Recently, new therapeutic approaches, such as the use of mesenchymal stem cells, have shown promising results. The adipose tissue is a good source of these naturally occurring regenerative cells, due to its abundance and easy access. In addition, it can be used to provide cushioning and filling of structural defects. The 1-year safety and outcome of a single intra-articular injection of autologous and micro-fragmented adipose tissue in 30 patients affected by diffuse degenerative chondral lesions was evaluated. Methods Micro-fragmented adipose tissue was obtained using a minimal manipulation technique in a closed system. The safety of the procedure was evaluated by recording type and incidence of any adverse event. The clinical outcomes were determined using the KOOS, IKDC-subjective, Tegner Lysholm Knee, and VAS pain scales taken pre-operatively and at 12 months follow-up. A level of at least 10 points of improvement in the scores has been selected as cut-off representing a clinically significant difference. Results No relevant complications nor clinical worsening were recorded. A total median improvement of 20 points has been observed in IKDC-subjective and total KOOS, and a higher percentage of success was found in VAS pain and Tegner Lysholm Knee, where the total median improvement was 24 and 31 points, respectively. Conclusion The results of this study show the safety and feasibility of using autologous and micro-fragmented adipose tissue in patients affected by diffuse degenerative chondral lesions. The technique is safe, minimally invasive, simple, one-step, with low percentage of complications, and compliant with the regulatory panorama. |
| first_indexed | 2024-03-08T08:28:08Z |
| format | Article |
| id | doaj.art-1d2801db06f246f2914072b741f102ef |
| institution | Directory Open Access Journal |
| issn | 2197-1153 |
| language | English |
| last_indexed | 2025-03-22T04:19:29Z |
| publishDate | 2017-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Experimental Orthopaedics |
| spelling | doaj.art-1d2801db06f246f2914072b741f102ef2024-04-28T07:57:31ZengWileyJournal of Experimental Orthopaedics2197-11532017-10-01411710.1186/s40634-017-0108-2Autologous and micro-fragmented adipose tissue for the treatment of diffuse degenerative knee osteoarthritisA. Russo0V. Condello1V. Madonna2M. Guerriero3C. Zorzi4Orthopaedic Department, Sacro Cuore - Don Calabria HospitalOrthopaedic Department, Sacro Cuore - Don Calabria HospitalOrthopaedic Department, Sacro Cuore - Don Calabria HospitalComputer Science Department, University of VeronaOrthopaedic Department, Sacro Cuore - Don Calabria HospitalAbstract Background Chondral lesions of the knee represent a challenge for the orthopaedic surgeon. Several treatments have been proposed with variable success rate. Recently, new therapeutic approaches, such as the use of mesenchymal stem cells, have shown promising results. The adipose tissue is a good source of these naturally occurring regenerative cells, due to its abundance and easy access. In addition, it can be used to provide cushioning and filling of structural defects. The 1-year safety and outcome of a single intra-articular injection of autologous and micro-fragmented adipose tissue in 30 patients affected by diffuse degenerative chondral lesions was evaluated. Methods Micro-fragmented adipose tissue was obtained using a minimal manipulation technique in a closed system. The safety of the procedure was evaluated by recording type and incidence of any adverse event. The clinical outcomes were determined using the KOOS, IKDC-subjective, Tegner Lysholm Knee, and VAS pain scales taken pre-operatively and at 12 months follow-up. A level of at least 10 points of improvement in the scores has been selected as cut-off representing a clinically significant difference. Results No relevant complications nor clinical worsening were recorded. A total median improvement of 20 points has been observed in IKDC-subjective and total KOOS, and a higher percentage of success was found in VAS pain and Tegner Lysholm Knee, where the total median improvement was 24 and 31 points, respectively. Conclusion The results of this study show the safety and feasibility of using autologous and micro-fragmented adipose tissue in patients affected by diffuse degenerative chondral lesions. The technique is safe, minimally invasive, simple, one-step, with low percentage of complications, and compliant with the regulatory panorama.http://link.springer.com/article/10.1186/s40634-017-0108-2Knee ChondropathyOsteoarthritisMSCsAdipose tissue |
| spellingShingle | A. Russo V. Condello V. Madonna M. Guerriero C. Zorzi Autologous and micro-fragmented adipose tissue for the treatment of diffuse degenerative knee osteoarthritis Journal of Experimental Orthopaedics Knee Chondropathy Osteoarthritis MSCs Adipose tissue |
| title | Autologous and micro-fragmented adipose tissue for the treatment of diffuse degenerative knee osteoarthritis |
| title_full | Autologous and micro-fragmented adipose tissue for the treatment of diffuse degenerative knee osteoarthritis |
| title_fullStr | Autologous and micro-fragmented adipose tissue for the treatment of diffuse degenerative knee osteoarthritis |
| title_full_unstemmed | Autologous and micro-fragmented adipose tissue for the treatment of diffuse degenerative knee osteoarthritis |
| title_short | Autologous and micro-fragmented adipose tissue for the treatment of diffuse degenerative knee osteoarthritis |
| title_sort | autologous and micro fragmented adipose tissue for the treatment of diffuse degenerative knee osteoarthritis |
| topic | Knee Chondropathy Osteoarthritis MSCs Adipose tissue |
| url | http://link.springer.com/article/10.1186/s40634-017-0108-2 |
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