TCF7L2 Polymorphism rs7903146 (C/T) and Gestational Diabetes Influence on Obstetric Outcome: A Romanian Case–Control Study
Gestational diabetes mellitus (GDM) is one of the most frequent predictors of obstetric outcome among Romanian pregnant women. Thus, we aimed to investigate the role of rs7903146 (C/T) TCF7L2 gene polymorphism in the presence of GDM and to evaluate the influence on maternal-fetal outcomes in a cohor...
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MDPI AG
2024-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/7/4039 |
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| author | Gheorghe Cruciat Andreea Roxana Florian Mariam-Suzana Chaikh-Sulaiman Adelina Staicu Gabriela Valentina Caracostea Lucia Maria Procopciuc Florin Stamatian Daniel Muresan |
| author_facet | Gheorghe Cruciat Andreea Roxana Florian Mariam-Suzana Chaikh-Sulaiman Adelina Staicu Gabriela Valentina Caracostea Lucia Maria Procopciuc Florin Stamatian Daniel Muresan |
| author_sort | Gheorghe Cruciat |
| collection | DOAJ |
| description | Gestational diabetes mellitus (GDM) is one of the most frequent predictors of obstetric outcome among Romanian pregnant women. Thus, we aimed to investigate the role of rs7903146 (C/T) TCF7L2 gene polymorphism in the presence of GDM and to evaluate the influence on maternal-fetal outcomes in a cohort of pregnant women from Northern Transylvania. Our prospective case–control study was performed in a tertiary maternity center on 61 patients diagnosed with GDM and 55 normal pregnant patients. The patients were genotyped for rs7903146 (C/T) polymorphism of the TCF7L2 gene using the PCR-RFLP method between 24 and 28 weeks of gestation. The minor T allele was associated with a high risk of developing GDM (OR 1.71 [95% CI 0.82–3.59]) if both heterozygote and homozygote types were considered. Also, a higher risk of developing GDM was observed in homozygous carriers (OR 3.26 [95% CI 1.10–9.68]). Women with the TT genotype were more likely to require insulin therapy during pregnancy than other genotypes with a 5.67-fold increased risk ([1.61–19.97], <i>p</i> = 0.015). TT homozygote type was significantly associated with fetal macrosomia for birth weights greater than the 95th percentile (<i>p</i> = 0.034). The homozygous TT genotype is associated with an increased risk of developing GDM. Also, rs7903146 (C/T) TCF7L2 variant is accompanied by a high probability of developing insulin-dependent gestational diabetes mellitus (ID-GDM). The presence of at least one minor T allele was associated with a higher risk of fetal macrosomia. |
| first_indexed | 2024-04-24T10:41:58Z |
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| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-04-24T10:41:58Z |
| publishDate | 2024-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-1d2bda1667a14525a7683f55d34b94292024-04-12T13:20:28ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-04-01257403910.3390/ijms25074039TCF7L2 Polymorphism rs7903146 (C/T) and Gestational Diabetes Influence on Obstetric Outcome: A Romanian Case–Control StudyGheorghe Cruciat0Andreea Roxana Florian1Mariam-Suzana Chaikh-Sulaiman2Adelina Staicu3Gabriela Valentina Caracostea4Lucia Maria Procopciuc5Florin Stamatian6Daniel Muresan7Mother and Child Department, Obstetrics and Gynecology I, “Iuliu Haţieganu” University of Medicine and Pharmacy Cluj-Napoca, 400347 Cluj-Napoca, RomaniaMother and Child Department, Obstetrics and Gynecology I, “Iuliu Haţieganu” University of Medicine and Pharmacy Cluj-Napoca, 400347 Cluj-Napoca, RomaniaMother and Child Department, Obstetrics and Gynecology I, “Iuliu Haţieganu” University of Medicine and Pharmacy Cluj-Napoca, 400347 Cluj-Napoca, RomaniaMother and Child Department, Obstetrics and Gynecology I, “Iuliu Haţieganu” University of Medicine and Pharmacy Cluj-Napoca, 400347 Cluj-Napoca, RomaniaMother and Child Department, Obstetrics and Gynecology I, “Iuliu Haţieganu” University of Medicine and Pharmacy Cluj-Napoca, 400347 Cluj-Napoca, RomaniaDepartment of Medical Biochemistry, “Iuliu Haţieganu” University of Medicine and Pharmacy Cluj-Napoca, 400347 Cluj-Napoca, RomaniaImogen Clinical Research Centre, 400347 Cluj-Napoca, RomaniaMother and Child Department, Obstetrics and Gynecology I, “Iuliu Haţieganu” University of Medicine and Pharmacy Cluj-Napoca, 400347 Cluj-Napoca, RomaniaGestational diabetes mellitus (GDM) is one of the most frequent predictors of obstetric outcome among Romanian pregnant women. Thus, we aimed to investigate the role of rs7903146 (C/T) TCF7L2 gene polymorphism in the presence of GDM and to evaluate the influence on maternal-fetal outcomes in a cohort of pregnant women from Northern Transylvania. Our prospective case–control study was performed in a tertiary maternity center on 61 patients diagnosed with GDM and 55 normal pregnant patients. The patients were genotyped for rs7903146 (C/T) polymorphism of the TCF7L2 gene using the PCR-RFLP method between 24 and 28 weeks of gestation. The minor T allele was associated with a high risk of developing GDM (OR 1.71 [95% CI 0.82–3.59]) if both heterozygote and homozygote types were considered. Also, a higher risk of developing GDM was observed in homozygous carriers (OR 3.26 [95% CI 1.10–9.68]). Women with the TT genotype were more likely to require insulin therapy during pregnancy than other genotypes with a 5.67-fold increased risk ([1.61–19.97], <i>p</i> = 0.015). TT homozygote type was significantly associated with fetal macrosomia for birth weights greater than the 95th percentile (<i>p</i> = 0.034). The homozygous TT genotype is associated with an increased risk of developing GDM. Also, rs7903146 (C/T) TCF7L2 variant is accompanied by a high probability of developing insulin-dependent gestational diabetes mellitus (ID-GDM). The presence of at least one minor T allele was associated with a higher risk of fetal macrosomia.https://www.mdpi.com/1422-0067/25/7/4039gestational diabetes mellitusrs7903146 (C/T) polymorphismTCF7L2 genefetal macrosomia |
| spellingShingle | Gheorghe Cruciat Andreea Roxana Florian Mariam-Suzana Chaikh-Sulaiman Adelina Staicu Gabriela Valentina Caracostea Lucia Maria Procopciuc Florin Stamatian Daniel Muresan TCF7L2 Polymorphism rs7903146 (C/T) and Gestational Diabetes Influence on Obstetric Outcome: A Romanian Case–Control Study International Journal of Molecular Sciences gestational diabetes mellitus rs7903146 (C/T) polymorphism TCF7L2 gene fetal macrosomia |
| title | TCF7L2 Polymorphism rs7903146 (C/T) and Gestational Diabetes Influence on Obstetric Outcome: A Romanian Case–Control Study |
| title_full | TCF7L2 Polymorphism rs7903146 (C/T) and Gestational Diabetes Influence on Obstetric Outcome: A Romanian Case–Control Study |
| title_fullStr | TCF7L2 Polymorphism rs7903146 (C/T) and Gestational Diabetes Influence on Obstetric Outcome: A Romanian Case–Control Study |
| title_full_unstemmed | TCF7L2 Polymorphism rs7903146 (C/T) and Gestational Diabetes Influence on Obstetric Outcome: A Romanian Case–Control Study |
| title_short | TCF7L2 Polymorphism rs7903146 (C/T) and Gestational Diabetes Influence on Obstetric Outcome: A Romanian Case–Control Study |
| title_sort | tcf7l2 polymorphism rs7903146 c t and gestational diabetes influence on obstetric outcome a romanian case control study |
| topic | gestational diabetes mellitus rs7903146 (C/T) polymorphism TCF7L2 gene fetal macrosomia |
| url | https://www.mdpi.com/1422-0067/25/7/4039 |
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