Molecular Docking and In Silico Study of Denileukin Diftitox: Comparison of Wild Type With C519S Mutant

Molecular Docking and In Silico Study of Denileukin Diftitox: Comparison of Wild Type With C519S Mutant

Background: Denileukin diftitox (trade name, Ontak) is the first recombinant immunotoxin (IM), in which the binding domain of diphtheria toxin has been replaced by the amino acid sequence of human interleukin-2 (DT389IL-2) using genetic engineering. Purity, stability, and structural property of the...

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Bibliographic Details
Main Authors: Mohamad Najarasl, Mehdi Zeinoddini, Ali Reza Saeeidinia, Reza Hasan Sajedi
Format: Article
Language:English
Published: Mazandaran University of Medical Sciences and Health Services 2020-05-01
Series:Research in Molecular Medicine
Subjects:
immunotoxin
denileukin diftitox
refolding process
prediction
bioinformatic software
docking.
Online Access:http://rmm.mazums.ac.ir/article-1-346-en.html

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