Transition-metal-catalyzed C–H bond activation as a sustainable strategy for the synthesis of fluorinated molecules: an overview
The last decade has witnessed the emergence of innovative synthetic tools for the synthesis of fluorinated molecules. Among these approaches, the transition-metal-catalyzed functionalization of various scaffolds with a panel of fluorinated groups (XRF, X = S, Se, O) offered straightforward access to...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2023-04-01
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| Series: | Beilstein Journal of Organic Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjoc.19.35 |
| _version_ | 1797835431032651776 |
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| author | Louis Monsigny Floriane Doche Tatiana Besset |
| author_facet | Louis Monsigny Floriane Doche Tatiana Besset |
| author_sort | Louis Monsigny |
| collection | DOAJ |
| description | The last decade has witnessed the emergence of innovative synthetic tools for the synthesis of fluorinated molecules. Among these approaches, the transition-metal-catalyzed functionalization of various scaffolds with a panel of fluorinated groups (XRF, X = S, Se, O) offered straightforward access to high value-added compounds. This review will highlight the main advances made in the field with the transition-metal-catalyzed functionalization of C(sp2) and C(sp3) centers with SCF3, SeCF3, or OCH2CF3 groups among others, by C–H bond activation. The scope and limitations of these transformations are discussed in this review. |
| first_indexed | 2024-04-09T14:52:49Z |
| format | Article |
| id | doaj.art-1d2c9624ac3e41789d000a15fcf3d1a4 |
| institution | Directory Open Access Journal |
| issn | 1860-5397 |
| language | English |
| last_indexed | 2024-04-09T14:52:49Z |
| publishDate | 2023-04-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj.art-1d2c9624ac3e41789d000a15fcf3d1a42023-05-02T09:01:07ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972023-04-0119144847310.3762/bjoc.19.351860-5397-19-35Transition-metal-catalyzed C–H bond activation as a sustainable strategy for the synthesis of fluorinated molecules: an overviewLouis Monsigny0Floriane Doche1Tatiana Besset2Normandie University, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000 Rouen, France Normandie University, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000 Rouen, France Normandie University, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000 Rouen, France The last decade has witnessed the emergence of innovative synthetic tools for the synthesis of fluorinated molecules. Among these approaches, the transition-metal-catalyzed functionalization of various scaffolds with a panel of fluorinated groups (XRF, X = S, Se, O) offered straightforward access to high value-added compounds. This review will highlight the main advances made in the field with the transition-metal-catalyzed functionalization of C(sp2) and C(sp3) centers with SCF3, SeCF3, or OCH2CF3 groups among others, by C–H bond activation. The scope and limitations of these transformations are discussed in this review.https://doi.org/10.3762/bjoc.19.35c–h bond activationemergent fluorinated groupshomogeneous catalysisorganofluorine chemistrypalladiumsynthetic method |
| spellingShingle | Louis Monsigny Floriane Doche Tatiana Besset Transition-metal-catalyzed C–H bond activation as a sustainable strategy for the synthesis of fluorinated molecules: an overview Beilstein Journal of Organic Chemistry c–h bond activation emergent fluorinated groups homogeneous catalysis organofluorine chemistry palladium synthetic method |
| title | Transition-metal-catalyzed C–H bond activation as a sustainable strategy for the synthesis of fluorinated molecules: an overview |
| title_full | Transition-metal-catalyzed C–H bond activation as a sustainable strategy for the synthesis of fluorinated molecules: an overview |
| title_fullStr | Transition-metal-catalyzed C–H bond activation as a sustainable strategy for the synthesis of fluorinated molecules: an overview |
| title_full_unstemmed | Transition-metal-catalyzed C–H bond activation as a sustainable strategy for the synthesis of fluorinated molecules: an overview |
| title_short | Transition-metal-catalyzed C–H bond activation as a sustainable strategy for the synthesis of fluorinated molecules: an overview |
| title_sort | transition metal catalyzed c h bond activation as a sustainable strategy for the synthesis of fluorinated molecules an overview |
| topic | c–h bond activation emergent fluorinated groups homogeneous catalysis organofluorine chemistry palladium synthetic method |
| url | https://doi.org/10.3762/bjoc.19.35 |
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