Iatrogenic aspergillus infection of the central nervous system in a pregnant woman
A healthy postnatal woman succumbed to fulminant iatrogenic Aspergillus infection of the central nervous system, following accidental inoculation into the subarachnoid space at spinal anesthesia, during an outbreak of Aspergillus meningitis in Sri Lanka. Autopsy revealed extensive Aspergillus mening...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2009-07-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2009;volume=52;issue=3;spage=427;epage=429;aulast=Lokuhetty |
| _version_ | 1818921330333974528 |
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| author | Lokuhetty Menaka Wijesinghe Harshima Weerasundera Buddhika Dayapala A |
| author_facet | Lokuhetty Menaka Wijesinghe Harshima Weerasundera Buddhika Dayapala A |
| author_sort | Lokuhetty Menaka |
| collection | DOAJ |
| description | A healthy postnatal woman succumbed to fulminant iatrogenic Aspergillus infection of the central nervous system, following accidental inoculation into the subarachnoid space at spinal anesthesia, during an outbreak of Aspergillus meningitis in Sri Lanka. Autopsy revealed extensive Aspergillus meningitis and culture confirmed <i> Aspergillus fumigatus.</i> The thalamic parenchyma in the brain was invaded by fungal hyphae producing necrotizing angitis with thrombosis, thalamic infarcts and fungal abscesses. The directional growth of fungal hyphae from the extra-luminal side of blood vessels towards the lumen favored extension from the brain parenchyma over hematogenous spread. The spinal parenchyma was resistant to fungal invasion in spite of the heavy growth within the spinal meninges and initial inoculation at spinal level. Modulation of the immune response in pregnancy with depression of selective aspects of cell-mediated immunity probably contributed to rapid spread within the subarachnoid space, to involve the brain parenchyma leading to clinical deterioration and death. |
| first_indexed | 2024-12-20T01:35:56Z |
| format | Article |
| id | doaj.art-1d2ce225d2e94215be3db6d3e2f98263 |
| institution | Directory Open Access Journal |
| issn | 0377-4929 |
| language | English |
| last_indexed | 2024-12-20T01:35:56Z |
| publishDate | 2009-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-1d2ce225d2e94215be3db6d3e2f982632022-12-21T19:58:01ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292009-07-01523427429Iatrogenic aspergillus infection of the central nervous system in a pregnant womanLokuhetty MenakaWijesinghe HarshimaWeerasundera BuddhikaDayapala AA healthy postnatal woman succumbed to fulminant iatrogenic Aspergillus infection of the central nervous system, following accidental inoculation into the subarachnoid space at spinal anesthesia, during an outbreak of Aspergillus meningitis in Sri Lanka. Autopsy revealed extensive Aspergillus meningitis and culture confirmed <i> Aspergillus fumigatus.</i> The thalamic parenchyma in the brain was invaded by fungal hyphae producing necrotizing angitis with thrombosis, thalamic infarcts and fungal abscesses. The directional growth of fungal hyphae from the extra-luminal side of blood vessels towards the lumen favored extension from the brain parenchyma over hematogenous spread. The spinal parenchyma was resistant to fungal invasion in spite of the heavy growth within the spinal meninges and initial inoculation at spinal level. Modulation of the immune response in pregnancy with depression of selective aspects of cell-mediated immunity probably contributed to rapid spread within the subarachnoid space, to involve the brain parenchyma leading to clinical deterioration and death.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2009;volume=52;issue=3;spage=427;epage=429;aulast=LokuhettyAspergillosiscentral nervous system infectionsIatrogenicpostpartum |
| spellingShingle | Lokuhetty Menaka Wijesinghe Harshima Weerasundera Buddhika Dayapala A Iatrogenic aspergillus infection of the central nervous system in a pregnant woman Indian Journal of Pathology and Microbiology Aspergillosis central nervous system infections Iatrogenic postpartum |
| title | Iatrogenic aspergillus infection of the central nervous system in a pregnant woman |
| title_full | Iatrogenic aspergillus infection of the central nervous system in a pregnant woman |
| title_fullStr | Iatrogenic aspergillus infection of the central nervous system in a pregnant woman |
| title_full_unstemmed | Iatrogenic aspergillus infection of the central nervous system in a pregnant woman |
| title_short | Iatrogenic aspergillus infection of the central nervous system in a pregnant woman |
| title_sort | iatrogenic aspergillus infection of the central nervous system in a pregnant woman |
| topic | Aspergillosis central nervous system infections Iatrogenic postpartum |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2009;volume=52;issue=3;spage=427;epage=429;aulast=Lokuhetty |
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