Respiratory Syncytial Virus in Pregnant Women: Systematic Review and Meta-Analysis
Human Respiratory Syncytial Virus (RSV) is a highly contagious viral pathogen. In infants, it is usually listed among the main causes of medical referrals and hospitalizations, particularly among newborns. While waiting for the results of early randomized controlled trials on maternal vaccination ag...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Women |
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| Online Access: | https://www.mdpi.com/2673-4184/2/2/16 |
| _version_ | 1827655682370830336 |
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| author | Matteo Riccò Pietro Ferraro Silvia Corrado Alessandro Zaniboni Elia Satta Silvia Ranzieri |
| author_facet | Matteo Riccò Pietro Ferraro Silvia Corrado Alessandro Zaniboni Elia Satta Silvia Ranzieri |
| author_sort | Matteo Riccò |
| collection | DOAJ |
| description | Human Respiratory Syncytial Virus (RSV) is a highly contagious viral pathogen. In infants, it is usually listed among the main causes of medical referrals and hospitalizations, particularly among newborns. While waiting for the results of early randomized controlled trials on maternal vaccination against RSV, the present systematic review and meta-analysis aimed to collect available evidence on maternal RSV infections. According to the PRISMA statement, Pubmed, Embase, and pre-print archive medRxiv.og were searched for eligible studies published up to 1 April 2022. Raw data included the incidence of RSV infection among sampled pregnant women, and the occurrence of complications. Data were then pooled in a random-effects model. Heterogeneity was assessed using the I<sup>2</sup> measure, while reporting bias was assessed by means of funnel plots and regression analysis. A total of 5 studies for 282,918 pregnancies were retrieved, with a pooled prevalence of 0.2 per 100 pregnancies and 2.5 per 100 pregnancies with respiratory tract infections. Neither maternal deaths nor miscarriages were reported. Even though detailed data were available only for 6309 pregnancies and 33 RSV cases, infant outcomes such as low birth weight and preterm delivery were rare (in both cases 0.04%), but up to 9.1% in cases where RSV diagnosis was confirmed. No substantially increased risk for preterm delivery (RR 1.395; 95%CI 0.566 to 3.434) and giving birth to a low-birth-weight infant (RR 0.509; 95%CI 0.134 to 1.924) was eventually identified. <i>Conclusions</i>. Although RSV is uncommonly detected among pregnant women, incident cases were associated with a relatively high share of complications. However, heterogeneous design and the quality of retrieved reports stress the need for specifically designed studies. |
| first_indexed | 2024-03-09T22:11:04Z |
| format | Article |
| id | doaj.art-1d2e5d22dd584ca7b6cfbcb97125501f |
| institution | Directory Open Access Journal |
| issn | 2673-4184 |
| language | English |
| last_indexed | 2024-03-09T22:11:04Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Women |
| spelling | doaj.art-1d2e5d22dd584ca7b6cfbcb97125501f2023-11-23T19:31:07ZengMDPI AGWomen2673-41842022-06-012214716010.3390/women2020016Respiratory Syncytial Virus in Pregnant Women: Systematic Review and Meta-AnalysisMatteo Riccò0Pietro Ferraro1Silvia Corrado2Alessandro Zaniboni3Elia Satta4Silvia Ranzieri5AUSL–IRCCS di Reggio Emilia, Servizio di Prevenzione e Sicurezza Negli Ambienti di Lavoro (SPSAL), Local Health Unit of Reggio Emilia, Via Amendola n. 2, I-42122 Reggio Emilia, ItalyOccupational Medicine Unit, Direzione Sanità, Italian Railways’ Infrastructure Division, RFI SpA, Piazza della Croce Rossa n. 1, I-00161 Rome, ItalyDepartment of Medicine DAME, Division of Pediatrics, University of Udine, Via delle Scienze, n. 206, I-33100 Udine, ItalyDepartment of Medicine and Surgery, University of Parma, Via Gramsci 14, I-43126 Parma, ItalyDepartment of Medicine and Surgery, University of Parma, Via Gramsci 14, I-43126 Parma, ItalyDepartment of Medicine and Surgery, University of Parma, Via Gramsci 14, I-43126 Parma, ItalyHuman Respiratory Syncytial Virus (RSV) is a highly contagious viral pathogen. In infants, it is usually listed among the main causes of medical referrals and hospitalizations, particularly among newborns. While waiting for the results of early randomized controlled trials on maternal vaccination against RSV, the present systematic review and meta-analysis aimed to collect available evidence on maternal RSV infections. According to the PRISMA statement, Pubmed, Embase, and pre-print archive medRxiv.og were searched for eligible studies published up to 1 April 2022. Raw data included the incidence of RSV infection among sampled pregnant women, and the occurrence of complications. Data were then pooled in a random-effects model. Heterogeneity was assessed using the I<sup>2</sup> measure, while reporting bias was assessed by means of funnel plots and regression analysis. A total of 5 studies for 282,918 pregnancies were retrieved, with a pooled prevalence of 0.2 per 100 pregnancies and 2.5 per 100 pregnancies with respiratory tract infections. Neither maternal deaths nor miscarriages were reported. Even though detailed data were available only for 6309 pregnancies and 33 RSV cases, infant outcomes such as low birth weight and preterm delivery were rare (in both cases 0.04%), but up to 9.1% in cases where RSV diagnosis was confirmed. No substantially increased risk for preterm delivery (RR 1.395; 95%CI 0.566 to 3.434) and giving birth to a low-birth-weight infant (RR 0.509; 95%CI 0.134 to 1.924) was eventually identified. <i>Conclusions</i>. Although RSV is uncommonly detected among pregnant women, incident cases were associated with a relatively high share of complications. However, heterogeneous design and the quality of retrieved reports stress the need for specifically designed studies.https://www.mdpi.com/2673-4184/2/2/16respiratory syncytial virusrespiratory tract infectionsvaccinepregnancyepidemiology |
| spellingShingle | Matteo Riccò Pietro Ferraro Silvia Corrado Alessandro Zaniboni Elia Satta Silvia Ranzieri Respiratory Syncytial Virus in Pregnant Women: Systematic Review and Meta-Analysis Women respiratory syncytial virus respiratory tract infections vaccine pregnancy epidemiology |
| title | Respiratory Syncytial Virus in Pregnant Women: Systematic Review and Meta-Analysis |
| title_full | Respiratory Syncytial Virus in Pregnant Women: Systematic Review and Meta-Analysis |
| title_fullStr | Respiratory Syncytial Virus in Pregnant Women: Systematic Review and Meta-Analysis |
| title_full_unstemmed | Respiratory Syncytial Virus in Pregnant Women: Systematic Review and Meta-Analysis |
| title_short | Respiratory Syncytial Virus in Pregnant Women: Systematic Review and Meta-Analysis |
| title_sort | respiratory syncytial virus in pregnant women systematic review and meta analysis |
| topic | respiratory syncytial virus respiratory tract infections vaccine pregnancy epidemiology |
| url | https://www.mdpi.com/2673-4184/2/2/16 |
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