Compromised Myelin and Axonal Molecular Organization Following Adult-Onset Sulfatide Depletion

Compromised Myelin and Axonal Molecular Organization Following Adult-Onset Sulfatide Depletion

3-O-sulfogalactosylceramide, or sulfatide, is a prominent myelin glycosphingolipid reduced in the normal appearing white matter (NAWM) in Multiple Sclerosis (MS), indicating that sulfatide reduction precedes demyelination. Using a mouse model that is constitutively depleted of sulfatide, we previous...

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Bibliographic Details
Main Authors: Elizabeth Dustin, Edna Suarez-Pozos, Camryn Stotesberry, Shulan Qiu, Juan Pablo Palavicini, Xianlin Han, Jeffrey L. Dupree
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Biomedicines
Subjects:
sulfatide
lipid rafts
sphingolipid
myelin
multiple sclerosis
Online Access:https://www.mdpi.com/2227-9059/11/5/1431

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