New observations on maternal age effect on germline de novo mutations
The study of germline mutations has been greatly enhanced by massive parallel sequencing technologies. Here the authors use deep sequencing data from nearly 700 parent-child trios to show maternal age has a small but significant correlation with the number of de novomutations in the offspring.
Bibliographic Details
| Main Authors: |
Wendy S. W. Wong,
Benjamin D. Solomon,
Dale L. Bodian,
Prachi Kothiyal,
Greg Eley,
Kathi C. Huddleston,
Robin Baker,
Dzung C. Thach,
Ramaswamy K. Iyer,
Joseph G. Vockley,
John E. Niederhuber |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2016-01-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms10486
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