Tissue plasminogen activator worsens experimental autoimmune encephalomyelitis by complementary actions on lymphoid and myeloid cell responses

Tissue plasminogen activator worsens experimental autoimmune encephalomyelitis by complementary actions on lymphoid and myeloid cell responses

Abstract Background Tissue plasminogen activator (tPA) is a serine protease involved in fibrinolysis. It is released by endothelial cells, but also expressed by neurons and glial cells in the central nervous system (CNS). Interestingly, this enzyme also contributes to pathological processes in the C...

Full description

Bibliographic Details
Main Authors: Pauline Hélie, Celia Camacho-Toledano, Léonie Lesec, Célia Seillier, Antonio J. Miralles, Maria Cristina Ortega, Sylvaine Guérit, Héloïse Lebas, Isabelle Bardou, Virginia Vila-del Sol, Denis Vivien, Brigitte Le Mauff, Diego Clemente, Fabian Docagne, Olivier Toutirais
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Journal of Neuroinflammation
Subjects:
Tissue plasminogen activator
Neuroinflammation
Experimental autoimmune encephalomyelitis
T cell response
Antigen-presenting cells
Online Access:https://doi.org/10.1186/s12974-021-02102-5

Similar Items

Similar Items