Case report of successful live birth in an infertile couple with male idiopathic hypogonadotropic hypogonadism/azoospermia and atypical polypoid adenomyoma of the uterus
The authors report a unique case of a successful live birth in an infertile couple both with male factor (idiopathic hypogonadotropic hypogonadism, IHH/azoospermia) and female factor [atypical polypoid adenomyoma (APA) of the uterus]. According to the history of ejaculation disorder and low values o...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2020-12-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/47/6/10.31083/j.ceog.2020.06.5496 |
| _version_ | 1818210724840734720 |
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| author | K. Okuno K. Kitaya N. Kim K. Yamaguchi H. Matsubayashi T. Ishikawa |
| author_facet | K. Okuno K. Kitaya N. Kim K. Yamaguchi H. Matsubayashi T. Ishikawa |
| author_sort | K. Okuno |
| collection | DOAJ |
| description | The authors report a unique case of a successful live birth in an infertile couple both with male factor (idiopathic hypogonadotropic hypogonadism, IHH/azoospermia) and female factor [atypical polypoid adenomyoma (APA) of the uterus]. According to the history of ejaculation disorder and low values of serum follicle stimulating hormone, luteinizing hormone, and testosterone concentration, an infertile man was diagnosed with IHH. Gonadotropin therapy failed to produce ejaculated spermatozoa, but microdissection testicular sperm extraction was successful for retrieval and cryopreservation of motile testicular spermatozoa. Meanwhile, in the course of infertility workup for his female partner, fluid hysteroscopy detected multiple endometrial polypoid lesions in her uterine cavity. Hysteroscopic resection and histopathologic examinations revealed that the lesions were APA. Repeated hysteroscopic and histopathologic examinations did not find any evidence of the recurrence. She underwent controlled ovarian stimulation, oocyte pickup, and intracytoplasmic sperm injection using thawed testicular spermatozoa. She had a pregnancy in the first frozen-thawed blastocyst transfer cycle and gave birth to a healthy baby. |
| first_indexed | 2024-12-12T05:21:10Z |
| format | Article |
| id | doaj.art-1d32bafd2f57451ea4e07938e6046200 |
| institution | Directory Open Access Journal |
| issn | 0390-6663 |
| language | English |
| last_indexed | 2024-12-12T05:21:10Z |
| publishDate | 2020-12-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj.art-1d32bafd2f57451ea4e07938e60462002022-12-22T00:36:36ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632020-12-0147697297310.31083/j.ceog.2020.06.5496S0390-6663(20)00388-7Case report of successful live birth in an infertile couple with male idiopathic hypogonadotropic hypogonadism/azoospermia and atypical polypoid adenomyoma of the uterusK. Okuno0K. Kitaya1N. Kim2K. Yamaguchi3H. Matsubayashi4T. Ishikawa5Reproduction Clinic Osaka, Grand Front Osaka Tower A 15F, 4-20 Oofuka-cho, Kita-ku, Osaka, 530-0011, JapanReproduction Clinic Osaka, Grand Front Osaka Tower A 15F, 4-20 Oofuka-cho, Kita-ku, Osaka, 530-0011, JapanReproduction Clinic Osaka, Grand Front Osaka Tower A 15F, 4-20 Oofuka-cho, Kita-ku, Osaka, 530-0011, JapanReproduction Clinic Osaka, Grand Front Osaka Tower A 15F, 4-20 Oofuka-cho, Kita-ku, Osaka, 530-0011, JapanReproduction Clinic Osaka, Grand Front Osaka Tower A 15F, 4-20 Oofuka-cho, Kita-ku, Osaka, 530-0011, JapanReproduction Clinic Osaka, Grand Front Osaka Tower A 15F, 4-20 Oofuka-cho, Kita-ku, Osaka, 530-0011, JapanThe authors report a unique case of a successful live birth in an infertile couple both with male factor (idiopathic hypogonadotropic hypogonadism, IHH/azoospermia) and female factor [atypical polypoid adenomyoma (APA) of the uterus]. According to the history of ejaculation disorder and low values of serum follicle stimulating hormone, luteinizing hormone, and testosterone concentration, an infertile man was diagnosed with IHH. Gonadotropin therapy failed to produce ejaculated spermatozoa, but microdissection testicular sperm extraction was successful for retrieval and cryopreservation of motile testicular spermatozoa. Meanwhile, in the course of infertility workup for his female partner, fluid hysteroscopy detected multiple endometrial polypoid lesions in her uterine cavity. Hysteroscopic resection and histopathologic examinations revealed that the lesions were APA. Repeated hysteroscopic and histopathologic examinations did not find any evidence of the recurrence. She underwent controlled ovarian stimulation, oocyte pickup, and intracytoplasmic sperm injection using thawed testicular spermatozoa. She had a pregnancy in the first frozen-thawed blastocyst transfer cycle and gave birth to a healthy baby.https://www.imrpress.com/journal/CEOG/47/6/10.31083/j.ceog.2020.06.5496azoospermiaidiopathic hypogonadotropic hypogonadismatypical polypoid adenomyomainfertility |
| spellingShingle | K. Okuno K. Kitaya N. Kim K. Yamaguchi H. Matsubayashi T. Ishikawa Case report of successful live birth in an infertile couple with male idiopathic hypogonadotropic hypogonadism/azoospermia and atypical polypoid adenomyoma of the uterus Clinical and Experimental Obstetrics & Gynecology azoospermia idiopathic hypogonadotropic hypogonadism atypical polypoid adenomyoma infertility |
| title | Case report of successful live birth in an infertile couple with male idiopathic hypogonadotropic hypogonadism/azoospermia and atypical polypoid adenomyoma of the uterus |
| title_full | Case report of successful live birth in an infertile couple with male idiopathic hypogonadotropic hypogonadism/azoospermia and atypical polypoid adenomyoma of the uterus |
| title_fullStr | Case report of successful live birth in an infertile couple with male idiopathic hypogonadotropic hypogonadism/azoospermia and atypical polypoid adenomyoma of the uterus |
| title_full_unstemmed | Case report of successful live birth in an infertile couple with male idiopathic hypogonadotropic hypogonadism/azoospermia and atypical polypoid adenomyoma of the uterus |
| title_short | Case report of successful live birth in an infertile couple with male idiopathic hypogonadotropic hypogonadism/azoospermia and atypical polypoid adenomyoma of the uterus |
| title_sort | case report of successful live birth in an infertile couple with male idiopathic hypogonadotropic hypogonadism azoospermia and atypical polypoid adenomyoma of the uterus |
| topic | azoospermia idiopathic hypogonadotropic hypogonadism atypical polypoid adenomyoma infertility |
| url | https://www.imrpress.com/journal/CEOG/47/6/10.31083/j.ceog.2020.06.5496 |
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