The Relationship Between Depression and Anxiety Symptoms of Adult PWE and Caregivers in a Tertiary Center
BackgroundAlthough several studies have emphasized the association between epilepsy and psychiatric disorders, fewer have investigated the impact of epilepsy on caregivers' emotional status, mainly in adult people with epilepsy (PWE). Here we investigated depressive symptoms, suicidal ideation,...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.766009/full |
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| author | Rafael Batista João Rafael Batista João Mateus Henrique Nogueira Mateus Henrique Nogueira Márcia Elisabete Morita-Sherman Márcia Elisabete Morita-Sherman Marina Koutsodontis Machado Alvim Marina Koutsodontis Machado Alvim Steven Johnny Steven Johnny Haryton Pereira Haryton Pereira Hildete Prisco Pinheiro Fernando Cendes Fernando Cendes Clarissa Lin Yasuda Clarissa Lin Yasuda |
| author_facet | Rafael Batista João Rafael Batista João Mateus Henrique Nogueira Mateus Henrique Nogueira Márcia Elisabete Morita-Sherman Márcia Elisabete Morita-Sherman Marina Koutsodontis Machado Alvim Marina Koutsodontis Machado Alvim Steven Johnny Steven Johnny Haryton Pereira Haryton Pereira Hildete Prisco Pinheiro Fernando Cendes Fernando Cendes Clarissa Lin Yasuda Clarissa Lin Yasuda |
| author_sort | Rafael Batista João |
| collection | DOAJ |
| description | BackgroundAlthough several studies have emphasized the association between epilepsy and psychiatric disorders, fewer have investigated the impact of epilepsy on caregivers' emotional status, mainly in adult people with epilepsy (PWE). Here we investigated depressive symptoms, suicidal ideation, and anxiety symptoms in a large group of adult PWE and their caregivers.MethodsWe analyzed symptoms of depression [with the Beck Depression Inventory-II (BDI-II)], suicidal ideation (with BDI-II item 9), and anxiety symptoms (with the Beck Anxiety Inventory) in a large group of adult PWE [N = 548 (60% women; median age 41)] and caregivers [N = 191 (72% women; median age 47)] from a Brazilian tertiary center, considering sociodemographic and clinical aspects. We also applied the Liverpool Adverse Events Profile to assess anti-seizure drugs adverse events.ResultsWhile the presence (p = 0.026) (and intensity, p = 0.007) of depressive symptoms and suicidal ideation (p = 0.02) were higher in PWE compared to caregivers, the proportion of clinical anxiety symptoms (p = 0.32) (and the intensity, p = 0.13) was similar in both groups. Although the rates of suicidal ideation were higher in focal epilepsy (20%), both generalized genetic epilepsy and caregivers also presented elevated frequencies (11%) of suicidal ideation. The analyses of 120 patient-caregiver dyads revealed that the intensity of depressive symptoms in PWE (but not anxiety) correlated with the intensity of depressive (r = 0.35; p < 0.001) and anxiety (r = 0.25; p = 0.01) symptoms in their caregivers. In the multivariate analyses of PWE, focal epilepsy (compared to GGE) was associated with clinical depressive symptoms (odds ratio, OR 2.1) and suicidal ideation (OR 3.2), while recurrent seizures (compared to the seizure-free group) were associated with suicidal ideation (OR 2.6) and anxiety symptoms (OR 2.1). Also, caregivers with anxiety symptoms were 8 times more likely to exhibit depressive symptoms, and those with depressive symptoms were 8 times more likely to present anxiety symptoms.ConclusionOur study suggests that specific attention for the caregivers' mental health is as essential as PWE. There is an urgent need for more studies involving caregivers to identify their emotional distress and provide adequate treatment. |
| first_indexed | 2024-12-24T04:29:30Z |
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| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-24T04:29:30Z |
| publishDate | 2022-03-01 |
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| series | Frontiers in Neurology |
| spelling | doaj.art-1d34348a7333437fabe92f19941e72152022-12-21T17:15:28ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-03-011310.3389/fneur.2022.766009766009The Relationship Between Depression and Anxiety Symptoms of Adult PWE and Caregivers in a Tertiary CenterRafael Batista João0Rafael Batista João1Mateus Henrique Nogueira2Mateus Henrique Nogueira3Márcia Elisabete Morita-Sherman4Márcia Elisabete Morita-Sherman5Marina Koutsodontis Machado Alvim6Marina Koutsodontis Machado Alvim7Steven Johnny8Steven Johnny9Haryton Pereira10Haryton Pereira11Hildete Prisco Pinheiro12Fernando Cendes13Fernando Cendes14Clarissa Lin Yasuda15Clarissa Lin Yasuda16Neuroimaging Laboratory, Department of Neurology, University of Campinas, Campinas, BrazilThe Brazilian Institute of Neuroscience and Neurotechnology, University of Campinas, Campinas, BrazilNeuroimaging Laboratory, Department of Neurology, University of Campinas, Campinas, BrazilThe Brazilian Institute of Neuroscience and Neurotechnology, University of Campinas, Campinas, BrazilNeuroimaging Laboratory, Department of Neurology, University of Campinas, Campinas, BrazilThe Brazilian Institute of Neuroscience and Neurotechnology, University of Campinas, Campinas, BrazilNeuroimaging Laboratory, Department of Neurology, University of Campinas, Campinas, BrazilThe Brazilian Institute of Neuroscience and Neurotechnology, University of Campinas, Campinas, BrazilNeuroimaging Laboratory, Department of Neurology, University of Campinas, Campinas, BrazilThe Brazilian Institute of Neuroscience and Neurotechnology, University of Campinas, Campinas, BrazilNeuroimaging Laboratory, Department of Neurology, University of Campinas, Campinas, BrazilThe Brazilian Institute of Neuroscience and Neurotechnology, University of Campinas, Campinas, BrazilInstitute of Mathematics, Statistics and Scientific Computing, University of Campinas, Campinas, BrazilNeuroimaging Laboratory, Department of Neurology, University of Campinas, Campinas, BrazilThe Brazilian Institute of Neuroscience and Neurotechnology, University of Campinas, Campinas, BrazilNeuroimaging Laboratory, Department of Neurology, University of Campinas, Campinas, BrazilThe Brazilian Institute of Neuroscience and Neurotechnology, University of Campinas, Campinas, BrazilBackgroundAlthough several studies have emphasized the association between epilepsy and psychiatric disorders, fewer have investigated the impact of epilepsy on caregivers' emotional status, mainly in adult people with epilepsy (PWE). Here we investigated depressive symptoms, suicidal ideation, and anxiety symptoms in a large group of adult PWE and their caregivers.MethodsWe analyzed symptoms of depression [with the Beck Depression Inventory-II (BDI-II)], suicidal ideation (with BDI-II item 9), and anxiety symptoms (with the Beck Anxiety Inventory) in a large group of adult PWE [N = 548 (60% women; median age 41)] and caregivers [N = 191 (72% women; median age 47)] from a Brazilian tertiary center, considering sociodemographic and clinical aspects. We also applied the Liverpool Adverse Events Profile to assess anti-seizure drugs adverse events.ResultsWhile the presence (p = 0.026) (and intensity, p = 0.007) of depressive symptoms and suicidal ideation (p = 0.02) were higher in PWE compared to caregivers, the proportion of clinical anxiety symptoms (p = 0.32) (and the intensity, p = 0.13) was similar in both groups. Although the rates of suicidal ideation were higher in focal epilepsy (20%), both generalized genetic epilepsy and caregivers also presented elevated frequencies (11%) of suicidal ideation. The analyses of 120 patient-caregiver dyads revealed that the intensity of depressive symptoms in PWE (but not anxiety) correlated with the intensity of depressive (r = 0.35; p < 0.001) and anxiety (r = 0.25; p = 0.01) symptoms in their caregivers. In the multivariate analyses of PWE, focal epilepsy (compared to GGE) was associated with clinical depressive symptoms (odds ratio, OR 2.1) and suicidal ideation (OR 3.2), while recurrent seizures (compared to the seizure-free group) were associated with suicidal ideation (OR 2.6) and anxiety symptoms (OR 2.1). Also, caregivers with anxiety symptoms were 8 times more likely to exhibit depressive symptoms, and those with depressive symptoms were 8 times more likely to present anxiety symptoms.ConclusionOur study suggests that specific attention for the caregivers' mental health is as essential as PWE. There is an urgent need for more studies involving caregivers to identify their emotional distress and provide adequate treatment.https://www.frontiersin.org/articles/10.3389/fneur.2022.766009/fullepilepsycaregiversdepressionanxietysuicidality |
| spellingShingle | Rafael Batista João Rafael Batista João Mateus Henrique Nogueira Mateus Henrique Nogueira Márcia Elisabete Morita-Sherman Márcia Elisabete Morita-Sherman Marina Koutsodontis Machado Alvim Marina Koutsodontis Machado Alvim Steven Johnny Steven Johnny Haryton Pereira Haryton Pereira Hildete Prisco Pinheiro Fernando Cendes Fernando Cendes Clarissa Lin Yasuda Clarissa Lin Yasuda The Relationship Between Depression and Anxiety Symptoms of Adult PWE and Caregivers in a Tertiary Center Frontiers in Neurology epilepsy caregivers depression anxiety suicidality |
| title | The Relationship Between Depression and Anxiety Symptoms of Adult PWE and Caregivers in a Tertiary Center |
| title_full | The Relationship Between Depression and Anxiety Symptoms of Adult PWE and Caregivers in a Tertiary Center |
| title_fullStr | The Relationship Between Depression and Anxiety Symptoms of Adult PWE and Caregivers in a Tertiary Center |
| title_full_unstemmed | The Relationship Between Depression and Anxiety Symptoms of Adult PWE and Caregivers in a Tertiary Center |
| title_short | The Relationship Between Depression and Anxiety Symptoms of Adult PWE and Caregivers in a Tertiary Center |
| title_sort | relationship between depression and anxiety symptoms of adult pwe and caregivers in a tertiary center |
| topic | epilepsy caregivers depression anxiety suicidality |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.766009/full |
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