Short-term exposure to antimony induces hepatotoxicity and metabolic remodeling in rats
Antimony (Sb) poses a significant threat to human health due to sharp increases in its exploitation and application globally, but few studies have explored the pathophysiological mechanisms of acute hepatotoxicity induced by Sb exposure. We established an in vivo model to comprehensively explore the...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651323003561 |
| _version_ | 1797840522842210304 |
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| author | Wen Gu Ruifang Pang Yuanyuan Chen Fuchang Deng Miao Zhang Zijin Shao Shuyi Zhang Huawei Duan Song Tang |
| author_facet | Wen Gu Ruifang Pang Yuanyuan Chen Fuchang Deng Miao Zhang Zijin Shao Shuyi Zhang Huawei Duan Song Tang |
| author_sort | Wen Gu |
| collection | DOAJ |
| description | Antimony (Sb) poses a significant threat to human health due to sharp increases in its exploitation and application globally, but few studies have explored the pathophysiological mechanisms of acute hepatotoxicity induced by Sb exposure. We established an in vivo model to comprehensively explore the endogenous mechanisms underlying liver injury induced by short-term Sb exposure. Adult female and male Sprague-Dawley rats were orally administrated various concentrations of potassium antimony tartrate for 28 days. After exposure, the serum Sb concentration, liver-to-body weight ratio, and serum glucose levels significantly increased in a dose-dependent manner. Body weight gain and serum concentrations of biomarkers of hepatic injury (e.g., total cholesterol, total protein, alkaline phosphatase, and the aspartate aminotransferase/alanine aminotransferase ratio) decreased with increasing Sb exposure. Through integrative non-targeted metabolome and lipidome analyses, alanine, aspartate, and glutamate metabolism; phosphatidylcholines; sphingomyelins; and phosphatidylinositols were the most significantly affected pathways in female and male rats exposed to Sb. Additionally, correlation analysis showed that the concentrations of certain metabolites and lipids (e.g., deoxycholic acid, N-methylproline, palmitoylcarnitine, glycerophospholipids, sphingomyelins, and glycerol) were significantly associated with hepatic injury biomarkers, indicating that metabolic remodeling may be involved in apical hepatotoxicity. Our study demonstrated that short-term exposure to Sb induces hepatotoxicity, possibly through a glycolipid metabolism disorder, providing an important reference for the health risks of Sb pollution. |
| first_indexed | 2024-04-09T16:16:43Z |
| format | Article |
| id | doaj.art-1d34f28af4594ceb9375873c56917847 |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-04-09T16:16:43Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-1d34f28af4594ceb9375873c569178472023-04-24T04:36:54ZengElsevierEcotoxicology and Environmental Safety0147-65132023-05-01256114852Short-term exposure to antimony induces hepatotoxicity and metabolic remodeling in ratsWen Gu0Ruifang Pang1Yuanyuan Chen2Fuchang Deng3Miao Zhang4Zijin Shao5Shuyi Zhang6Huawei Duan7Song Tang8Key Laboratory of Chemical Safety and Health, National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, ChinaInstitute of Precision Medicine, Peking University Shenzhen Hospital, Shenzhen 518036, ChinaKey Laboratory of Chemical Safety and Health, National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China; Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, ChinaKey Laboratory of Chemical Safety and Health, National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China; Corresponding author.China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China; Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China; Corresponding author at: China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.Antimony (Sb) poses a significant threat to human health due to sharp increases in its exploitation and application globally, but few studies have explored the pathophysiological mechanisms of acute hepatotoxicity induced by Sb exposure. We established an in vivo model to comprehensively explore the endogenous mechanisms underlying liver injury induced by short-term Sb exposure. Adult female and male Sprague-Dawley rats were orally administrated various concentrations of potassium antimony tartrate for 28 days. After exposure, the serum Sb concentration, liver-to-body weight ratio, and serum glucose levels significantly increased in a dose-dependent manner. Body weight gain and serum concentrations of biomarkers of hepatic injury (e.g., total cholesterol, total protein, alkaline phosphatase, and the aspartate aminotransferase/alanine aminotransferase ratio) decreased with increasing Sb exposure. Through integrative non-targeted metabolome and lipidome analyses, alanine, aspartate, and glutamate metabolism; phosphatidylcholines; sphingomyelins; and phosphatidylinositols were the most significantly affected pathways in female and male rats exposed to Sb. Additionally, correlation analysis showed that the concentrations of certain metabolites and lipids (e.g., deoxycholic acid, N-methylproline, palmitoylcarnitine, glycerophospholipids, sphingomyelins, and glycerol) were significantly associated with hepatic injury biomarkers, indicating that metabolic remodeling may be involved in apical hepatotoxicity. Our study demonstrated that short-term exposure to Sb induces hepatotoxicity, possibly through a glycolipid metabolism disorder, providing an important reference for the health risks of Sb pollution.http://www.sciencedirect.com/science/article/pii/S0147651323003561AntimonyMetabolomicsLipidomicsLiver injuryGlycolipid metabolismMetabolic disorders |
| spellingShingle | Wen Gu Ruifang Pang Yuanyuan Chen Fuchang Deng Miao Zhang Zijin Shao Shuyi Zhang Huawei Duan Song Tang Short-term exposure to antimony induces hepatotoxicity and metabolic remodeling in rats Ecotoxicology and Environmental Safety Antimony Metabolomics Lipidomics Liver injury Glycolipid metabolism Metabolic disorders |
| title | Short-term exposure to antimony induces hepatotoxicity and metabolic remodeling in rats |
| title_full | Short-term exposure to antimony induces hepatotoxicity and metabolic remodeling in rats |
| title_fullStr | Short-term exposure to antimony induces hepatotoxicity and metabolic remodeling in rats |
| title_full_unstemmed | Short-term exposure to antimony induces hepatotoxicity and metabolic remodeling in rats |
| title_short | Short-term exposure to antimony induces hepatotoxicity and metabolic remodeling in rats |
| title_sort | short term exposure to antimony induces hepatotoxicity and metabolic remodeling in rats |
| topic | Antimony Metabolomics Lipidomics Liver injury Glycolipid metabolism Metabolic disorders |
| url | http://www.sciencedirect.com/science/article/pii/S0147651323003561 |
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