Effect of intrathecal Bupivacaine–Lidocaine combination on motor block and analgesia period
Objective: To assess the effect of intrathecal Bupivacain–Lidocaine combination at different doses of Lidocaine (6 and 12 mg) on the onset and recovery of anesthesia. Methods: Ninety patients who were scheduled for elective lower abdominal surgery were randomly allocated into three equal groups: Gro...
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| Format: | Article |
| Language: | English |
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Faculty of Pharmacy, Cairo University
2012-06-01
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| Series: | Bulletin of Faculty of Pharmacy Cairo University |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1110093112000105 |
| _version_ | 1828081371501821952 |
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| author | Sara El-Adawy Azza Abd-El Alim Manal El-Hamamsy |
| author_facet | Sara El-Adawy Azza Abd-El Alim Manal El-Hamamsy |
| author_sort | Sara El-Adawy |
| collection | DOAJ |
| description | Objective: To assess the effect of intrathecal Bupivacain–Lidocaine combination at different doses of Lidocaine (6 and 12 mg) on the onset and recovery of anesthesia.
Methods: Ninety patients who were scheduled for elective lower abdominal surgery were randomly allocated into three equal groups: Group I; 30 patients received 1.5 mL hyperbaric 0.5% Bupivacaine + 0.6 mL saline. Group II; 30 patients received 1.5 mL hyperbaric 0.5% Bupivacaine + 0.6 mL 1% Lidocaine [6 mg] mixed. Group III; 30 patients received 1.5 mL hyperbaric 0.5% Bupivacaine + 0.6 mL 2% Lidocaine [12 mg]. Peak sensory block level, time to peak sensory block, times to two-segment, S2 regressions from peak sensory block, motor blocks at peak sensory block and total motor block duration, post anesthesia care unit stay time and analgesia time were measured.
Results: The median height of peak sensory block in Group III was higher than in Group I or II. Times to two-segment and S2 regressions from peak sensory block, motor block duration and PACU time were significantly reduced in Group II compared to Group I and III. No patient required general anesthesia. No patients experienced postdural puncture headache or TNS.
Conclusions: Lidocaine 1% (6 mg) mixed to spinal 1.5 mL hyperbaric 0.5% Bupivacaine (7.5 mg) can shorten the duration of Bupivacaine spinal anesthesia, provide more rapid recovery from the spinal anesthesia compared to the same dose of 0.5% Bupivacaine (7.5 mg) alone or the same dose of 0.5% Bupivacaine (7.5 mg) mixed with 0.6 mL 2% Lidocaine (12 mg). |
| first_indexed | 2024-04-11T03:34:10Z |
| format | Article |
| id | doaj.art-1d35ca32978b45009a914a9c1831c31d |
| institution | Directory Open Access Journal |
| issn | 1110-0931 |
| language | English |
| last_indexed | 2024-04-11T03:34:10Z |
| publishDate | 2012-06-01 |
| publisher | Faculty of Pharmacy, Cairo University |
| record_format | Article |
| series | Bulletin of Faculty of Pharmacy Cairo University |
| spelling | doaj.art-1d35ca32978b45009a914a9c1831c31d2023-01-02T05:42:00ZengFaculty of Pharmacy, Cairo UniversityBulletin of Faculty of Pharmacy Cairo University1110-09312012-06-01501616510.1016/j.bfopcu.2012.03.001Effect of intrathecal Bupivacaine–Lidocaine combination on motor block and analgesia periodSara El-Adawy0Azza Abd-El Alim1Manal El-Hamamsy2Faculty of Pharmacy, Ain Shams University, Cairo, EgyptDepartment of Anesthesia, Faculty of Medicine, Ain Shams University, Cairo, EgyptClinical Pharmacy Department, Faculty of Pharmacy, Ain Shams University, Abasia, Cairo, EgyptObjective: To assess the effect of intrathecal Bupivacain–Lidocaine combination at different doses of Lidocaine (6 and 12 mg) on the onset and recovery of anesthesia. Methods: Ninety patients who were scheduled for elective lower abdominal surgery were randomly allocated into three equal groups: Group I; 30 patients received 1.5 mL hyperbaric 0.5% Bupivacaine + 0.6 mL saline. Group II; 30 patients received 1.5 mL hyperbaric 0.5% Bupivacaine + 0.6 mL 1% Lidocaine [6 mg] mixed. Group III; 30 patients received 1.5 mL hyperbaric 0.5% Bupivacaine + 0.6 mL 2% Lidocaine [12 mg]. Peak sensory block level, time to peak sensory block, times to two-segment, S2 regressions from peak sensory block, motor blocks at peak sensory block and total motor block duration, post anesthesia care unit stay time and analgesia time were measured. Results: The median height of peak sensory block in Group III was higher than in Group I or II. Times to two-segment and S2 regressions from peak sensory block, motor block duration and PACU time were significantly reduced in Group II compared to Group I and III. No patient required general anesthesia. No patients experienced postdural puncture headache or TNS. Conclusions: Lidocaine 1% (6 mg) mixed to spinal 1.5 mL hyperbaric 0.5% Bupivacaine (7.5 mg) can shorten the duration of Bupivacaine spinal anesthesia, provide more rapid recovery from the spinal anesthesia compared to the same dose of 0.5% Bupivacaine (7.5 mg) alone or the same dose of 0.5% Bupivacaine (7.5 mg) mixed with 0.6 mL 2% Lidocaine (12 mg).http://www.sciencedirect.com/science/article/pii/S1110093112000105LidocaineBupivacaineSpinal anesthesiaBupivacain–Lidocaine combination |
| spellingShingle | Sara El-Adawy Azza Abd-El Alim Manal El-Hamamsy Effect of intrathecal Bupivacaine–Lidocaine combination on motor block and analgesia period Bulletin of Faculty of Pharmacy Cairo University Lidocaine Bupivacaine Spinal anesthesia Bupivacain–Lidocaine combination |
| title | Effect of intrathecal Bupivacaine–Lidocaine combination on motor block and analgesia period |
| title_full | Effect of intrathecal Bupivacaine–Lidocaine combination on motor block and analgesia period |
| title_fullStr | Effect of intrathecal Bupivacaine–Lidocaine combination on motor block and analgesia period |
| title_full_unstemmed | Effect of intrathecal Bupivacaine–Lidocaine combination on motor block and analgesia period |
| title_short | Effect of intrathecal Bupivacaine–Lidocaine combination on motor block and analgesia period |
| title_sort | effect of intrathecal bupivacaine lidocaine combination on motor block and analgesia period |
| topic | Lidocaine Bupivacaine Spinal anesthesia Bupivacain–Lidocaine combination |
| url | http://www.sciencedirect.com/science/article/pii/S1110093112000105 |
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