Comparative study of three brands of antidiabetic drug, empagliflozin available in Karachi, Pakistan
Empagliflozin is a newer oral antidiabetic drug that treats people who have type-II Diabetes Mellitus. Empagliflozin reduces the reabsorption of filtered glucose and increases urine glucose excretion. The objective of the study is to analyze the physiochemical equivalence of different brands of Emp...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
University of Faisalabad
2023-04-01
|
| Series: | Journal of University Medical & Dental College |
| Subjects: | |
| Online Access: | https://jumdc.com/index.php/jumdc/article/view/781 |
| _version_ | 1797818762536157184 |
|---|---|
| author | Khadija Aslam Safila Naveed Fatima Qamar Halima Sadia Muhammad Ulusyar Khan Tajala Aman |
| author_facet | Khadija Aslam Safila Naveed Fatima Qamar Halima Sadia Muhammad Ulusyar Khan Tajala Aman |
| author_sort | Khadija Aslam |
| collection | DOAJ |
| description |
Empagliflozin is a newer oral antidiabetic drug that treats people who have type-II Diabetes Mellitus. Empagliflozin reduces the reabsorption of filtered glucose and increases urine glucose excretion. The objective of the study is to analyze the physiochemical equivalence of different brands of Empagliflozin available in Pakistan. Three different brands of Empagliflozin were evaluated for their physicochemical properties and cost-effectiveness. These brands were analyzed for different physicochemical tests for weight variation, hardness, friability, disintegration, and dissolution. All the brands had an average hardness of ≥2kg, which was suitable for an immediate-release tablet. All three brands had shown their friability variation within ±1% range specified by United State Pharmacopoeia (USP). The standard deviation was also calculated. All three brands showed good disintegration and dissolution profile which would aid in maximizing bioavailability and satisfying patient needs. The present findings suggest that almost all three brands of Empagliflozin that are available in Karachi meet the USP specification for quality control analysis.
|
| first_indexed | 2024-03-13T09:12:50Z |
| format | Article |
| id | doaj.art-1d36ef0e797442718dc8638c13f05b67 |
| institution | Directory Open Access Journal |
| issn | 2221-7827 2310-5542 |
| language | English |
| last_indexed | 2024-03-13T09:12:50Z |
| publishDate | 2023-04-01 |
| publisher | University of Faisalabad |
| record_format | Article |
| series | Journal of University Medical & Dental College |
| spelling | doaj.art-1d36ef0e797442718dc8638c13f05b672023-05-26T18:04:57ZengUniversity of FaisalabadJournal of University Medical & Dental College2221-78272310-55422023-04-01142Comparative study of three brands of antidiabetic drug, empagliflozin available in Karachi, PakistanKhadija Aslam0Safila Naveed1Fatima Qamar2Halima Sadia3Muhammad Ulusyar Khan4Tajala Aman5Student, Department of Pharmaceutical Chemistry, Jinnah University for Women.Dean Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Jinnah University for Women.Lecturer Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Jinnah University for Women.Lecturer Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Jinnah University for Women.Research Volunteer, Department of Medicine, Bolan Medical College, Quetta, Balochistan.MD, Department of Medicine, Bolan Medical College, Quetta, Balochistan. Empagliflozin is a newer oral antidiabetic drug that treats people who have type-II Diabetes Mellitus. Empagliflozin reduces the reabsorption of filtered glucose and increases urine glucose excretion. The objective of the study is to analyze the physiochemical equivalence of different brands of Empagliflozin available in Pakistan. Three different brands of Empagliflozin were evaluated for their physicochemical properties and cost-effectiveness. These brands were analyzed for different physicochemical tests for weight variation, hardness, friability, disintegration, and dissolution. All the brands had an average hardness of ≥2kg, which was suitable for an immediate-release tablet. All three brands had shown their friability variation within ±1% range specified by United State Pharmacopoeia (USP). The standard deviation was also calculated. All three brands showed good disintegration and dissolution profile which would aid in maximizing bioavailability and satisfying patient needs. The present findings suggest that almost all three brands of Empagliflozin that are available in Karachi meet the USP specification for quality control analysis. https://jumdc.com/index.php/jumdc/article/view/781EmpagliflozinPhysicochemical testingHardnessThicknessFriabilityDissolution |
| spellingShingle | Khadija Aslam Safila Naveed Fatima Qamar Halima Sadia Muhammad Ulusyar Khan Tajala Aman Comparative study of three brands of antidiabetic drug, empagliflozin available in Karachi, Pakistan Journal of University Medical & Dental College Empagliflozin Physicochemical testing Hardness Thickness Friability Dissolution |
| title | Comparative study of three brands of antidiabetic drug, empagliflozin available in Karachi, Pakistan |
| title_full | Comparative study of three brands of antidiabetic drug, empagliflozin available in Karachi, Pakistan |
| title_fullStr | Comparative study of three brands of antidiabetic drug, empagliflozin available in Karachi, Pakistan |
| title_full_unstemmed | Comparative study of three brands of antidiabetic drug, empagliflozin available in Karachi, Pakistan |
| title_short | Comparative study of three brands of antidiabetic drug, empagliflozin available in Karachi, Pakistan |
| title_sort | comparative study of three brands of antidiabetic drug empagliflozin available in karachi pakistan |
| topic | Empagliflozin Physicochemical testing Hardness Thickness Friability Dissolution |
| url | https://jumdc.com/index.php/jumdc/article/view/781 |
| work_keys_str_mv | AT khadijaaslam comparativestudyofthreebrandsofantidiabeticdrugempagliflozinavailableinkarachipakistan AT safilanaveed comparativestudyofthreebrandsofantidiabeticdrugempagliflozinavailableinkarachipakistan AT fatimaqamar comparativestudyofthreebrandsofantidiabeticdrugempagliflozinavailableinkarachipakistan AT halimasadia comparativestudyofthreebrandsofantidiabeticdrugempagliflozinavailableinkarachipakistan AT muhammadulusyarkhan comparativestudyofthreebrandsofantidiabeticdrugempagliflozinavailableinkarachipakistan AT tajalaaman comparativestudyofthreebrandsofantidiabeticdrugempagliflozinavailableinkarachipakistan |