Characterization of neuropsychiatric symptoms in a group of individuals with manifest or pre-motor Huntington’s disease in Medellín, Colombia
Introduction Huntington’s disease (HD) is a rare (1-9/100 000), inherited disease characterized by an elongated CAG repeat on chromosome 4p, leading to a degeneration of neurons. Also, psychiatric symptoms are very common in the early stage and may appear before motor symptoms. Objectives To chara...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2022-06-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933822011488/type/journal_article |
| _version_ | 1797616765516120064 |
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| author | D. Vasquez M. Agudelo C. Gomez D. Aguillon J. Quintero S. Rassi M. Zuluaga D. Pineda O. Buritica F. Lopera |
| author_facet | D. Vasquez M. Agudelo C. Gomez D. Aguillon J. Quintero S. Rassi M. Zuluaga D. Pineda O. Buritica F. Lopera |
| author_sort | D. Vasquez |
| collection | DOAJ |
| description |
Introduction
Huntington’s disease (HD) is a rare (1-9/100 000), inherited disease characterized by an elongated CAG repeat on chromosome 4p, leading to a degeneration of neurons. Also, psychiatric symptoms are very common in the early stage and may appear before motor symptoms.
Objectives
To characterize neuropsychiatric symptoms in a group of individuals with manifest or pre-motor Huntington’s disease in Medellín, Colombia.
Methods
Data obtained from clinical records of individuals with HD (motor-manifest or pre-motor with triplets count) evaluated for ENROLL-HD project in the Group of Neuroscience of Antioquia. We explored variables related to substances abuse, neuropsychiatric symptoms, the respective age of onset, sex, and triplet count when available.
Results
Twenty-six (53%) were women, 8% had a familiar history of psychotic illness in a first-degree relative and 88% presented motor symptoms. Also, 59% had a history of depression, 53% irritability, 57% aggressiveness, 34% apathy, 29% perseverative/obsessive behavior, 14% psychosis, and 30% mild cognitive impairment. Ten individuals (20%) had motor without neuropsychiatric symptoms. Also, thirty-seven individuals (76%) presented motor and neuropsychiatric symptoms; of these, 41% had neuropsychiatric symptoms before motor symptoms. No psychiatric symptoms were associated with the use of alcohol, cigarettes, or drugs of abuse.
Conclusions
Neuropsychiatric symptoms are highly prevalent among individuals with HD and studies oriented to create relevant knowledge for the development of advice oriented to people with this disease are necessary.
Disclosure
No significant relationships.
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| first_indexed | 2024-03-11T07:46:00Z |
| format | Article |
| id | doaj.art-1d378493de334e84a3abf7e9fd520db7 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:46:00Z |
| publishDate | 2022-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-1d378493de334e84a3abf7e9fd520db72023-11-17T05:07:39ZengCambridge University PressEuropean Psychiatry0924-93381778-35852022-06-0165S453S45310.1192/j.eurpsy.2022.1148Characterization of neuropsychiatric symptoms in a group of individuals with manifest or pre-motor Huntington’s disease in Medellín, ColombiaD. Vasquez0M. Agudelo1C. Gomez2D. Aguillon3J. Quintero4S. Rassi5M. Zuluaga6D. Pineda7O. Buritica8F. Lopera9Universidad de Antioquia, Grupo De Neurociencias De Antioquia, Medellin, ColombiaUniversidad de Antioquia, Neurología, Medellin, ColombiaUniversidad de Antioquia, Psiquiatría, Medellin, ColombiaUniversidad de Antioquia, Grupo De Neurociencias De Antioquia, Medellin, ColombiaUniversidad de Antioquia, Grupo De Neurociencias De Antioquia, Medellin, ColombiaUniversidad de Antioquia, Grupo De Neurociencias De Antioquia, Medellin, ColombiaUniversidad de Antioquia, Grupo De Neurociencias De Antioquia, Medellin, ColombiaUniversidad de Antioquia, Grupo De Neurociencias De Antioquia, Medellin, ColombiaUniversidad de Antioquia, Grupo De Neurociencias De Antioquia, Medellin, ColombiaUniversidad de Antioquia, Grupo De Neurociencias De Antioquia, Medellin, Colombia Introduction Huntington’s disease (HD) is a rare (1-9/100 000), inherited disease characterized by an elongated CAG repeat on chromosome 4p, leading to a degeneration of neurons. Also, psychiatric symptoms are very common in the early stage and may appear before motor symptoms. Objectives To characterize neuropsychiatric symptoms in a group of individuals with manifest or pre-motor Huntington’s disease in Medellín, Colombia. Methods Data obtained from clinical records of individuals with HD (motor-manifest or pre-motor with triplets count) evaluated for ENROLL-HD project in the Group of Neuroscience of Antioquia. We explored variables related to substances abuse, neuropsychiatric symptoms, the respective age of onset, sex, and triplet count when available. Results Twenty-six (53%) were women, 8% had a familiar history of psychotic illness in a first-degree relative and 88% presented motor symptoms. Also, 59% had a history of depression, 53% irritability, 57% aggressiveness, 34% apathy, 29% perseverative/obsessive behavior, 14% psychosis, and 30% mild cognitive impairment. Ten individuals (20%) had motor without neuropsychiatric symptoms. Also, thirty-seven individuals (76%) presented motor and neuropsychiatric symptoms; of these, 41% had neuropsychiatric symptoms before motor symptoms. No psychiatric symptoms were associated with the use of alcohol, cigarettes, or drugs of abuse. Conclusions Neuropsychiatric symptoms are highly prevalent among individuals with HD and studies oriented to create relevant knowledge for the development of advice oriented to people with this disease are necessary. Disclosure No significant relationships. https://www.cambridge.org/core/product/identifier/S0924933822011488/type/journal_articleHuntington’s diseaseMotor symptomsNeuropsychiatric symptomsChorea |
| spellingShingle | D. Vasquez M. Agudelo C. Gomez D. Aguillon J. Quintero S. Rassi M. Zuluaga D. Pineda O. Buritica F. Lopera Characterization of neuropsychiatric symptoms in a group of individuals with manifest or pre-motor Huntington’s disease in Medellín, Colombia European Psychiatry Huntington’s disease Motor symptoms Neuropsychiatric symptoms Chorea |
| title | Characterization of neuropsychiatric symptoms in a group of individuals with manifest or pre-motor Huntington’s disease in Medellín, Colombia |
| title_full | Characterization of neuropsychiatric symptoms in a group of individuals with manifest or pre-motor Huntington’s disease in Medellín, Colombia |
| title_fullStr | Characterization of neuropsychiatric symptoms in a group of individuals with manifest or pre-motor Huntington’s disease in Medellín, Colombia |
| title_full_unstemmed | Characterization of neuropsychiatric symptoms in a group of individuals with manifest or pre-motor Huntington’s disease in Medellín, Colombia |
| title_short | Characterization of neuropsychiatric symptoms in a group of individuals with manifest or pre-motor Huntington’s disease in Medellín, Colombia |
| title_sort | characterization of neuropsychiatric symptoms in a group of individuals with manifest or pre motor huntington s disease in medellin colombia |
| topic | Huntington’s disease Motor symptoms Neuropsychiatric symptoms Chorea |
| url | https://www.cambridge.org/core/product/identifier/S0924933822011488/type/journal_article |
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