Microbial Production of Human Milk Oligosaccharides
Human milk oligosaccharides (HMOs) are complex nonnutritive sugars present in human milk. These sugars possess prebiotic, immunomodulatory, and antagonistic properties towards pathogens and therefore are important for the health and well-being of newborn babies. Lower prevalence of breastfeeding aro...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/28/3/1491 |
| _version_ | 1827759753772662784 |
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| author | Dileep Sai Kumar Palur Shannon R. Pressley Shota Atsumi |
| author_facet | Dileep Sai Kumar Palur Shannon R. Pressley Shota Atsumi |
| author_sort | Dileep Sai Kumar Palur |
| collection | DOAJ |
| description | Human milk oligosaccharides (HMOs) are complex nonnutritive sugars present in human milk. These sugars possess prebiotic, immunomodulatory, and antagonistic properties towards pathogens and therefore are important for the health and well-being of newborn babies. Lower prevalence of breastfeeding around the globe, rising popularity of nutraceuticals, and low availability of HMOs have inspired efforts to develop economically feasible and efficient industrial-scale production platforms for HMOs. Recent progress in synthetic biology and metabolic engineering tools has enabled microbial systems to be a production system of HMOs. In this regard, the model organism <i>Escherichia coli</i> has emerged as the preferred production platform. Herein, we summarize the remarkable progress in the microbial production of HMOs and discuss the challenges and future opportunities in unraveling the scope of production of complex HMOs. We focus on the microbial production of five HMOs that have been approved for their commercialization. |
| first_indexed | 2024-03-11T09:32:04Z |
| format | Article |
| id | doaj.art-1d3841ebe02a4030901d6caf1b1d72d6 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T09:32:04Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-1d3841ebe02a4030901d6caf1b1d72d62023-11-16T17:33:15ZengMDPI AGMolecules1420-30492023-02-01283149110.3390/molecules28031491Microbial Production of Human Milk OligosaccharidesDileep Sai Kumar Palur0Shannon R. Pressley1Shota Atsumi2Department of Chemistry, University of California, Davis, Davis, CA 95616, USADepartment of Chemistry, University of California, Davis, Davis, CA 95616, USADepartment of Chemistry, University of California, Davis, Davis, CA 95616, USAHuman milk oligosaccharides (HMOs) are complex nonnutritive sugars present in human milk. These sugars possess prebiotic, immunomodulatory, and antagonistic properties towards pathogens and therefore are important for the health and well-being of newborn babies. Lower prevalence of breastfeeding around the globe, rising popularity of nutraceuticals, and low availability of HMOs have inspired efforts to develop economically feasible and efficient industrial-scale production platforms for HMOs. Recent progress in synthetic biology and metabolic engineering tools has enabled microbial systems to be a production system of HMOs. In this regard, the model organism <i>Escherichia coli</i> has emerged as the preferred production platform. Herein, we summarize the remarkable progress in the microbial production of HMOs and discuss the challenges and future opportunities in unraveling the scope of production of complex HMOs. We focus on the microbial production of five HMOs that have been approved for their commercialization.https://www.mdpi.com/1420-3049/28/3/1491human milk oligosaccharidessynthetic biologymetabolic engineering |
| spellingShingle | Dileep Sai Kumar Palur Shannon R. Pressley Shota Atsumi Microbial Production of Human Milk Oligosaccharides Molecules human milk oligosaccharides synthetic biology metabolic engineering |
| title | Microbial Production of Human Milk Oligosaccharides |
| title_full | Microbial Production of Human Milk Oligosaccharides |
| title_fullStr | Microbial Production of Human Milk Oligosaccharides |
| title_full_unstemmed | Microbial Production of Human Milk Oligosaccharides |
| title_short | Microbial Production of Human Milk Oligosaccharides |
| title_sort | microbial production of human milk oligosaccharides |
| topic | human milk oligosaccharides synthetic biology metabolic engineering |
| url | https://www.mdpi.com/1420-3049/28/3/1491 |
| work_keys_str_mv | AT dileepsaikumarpalur microbialproductionofhumanmilkoligosaccharides AT shannonrpressley microbialproductionofhumanmilkoligosaccharides AT shotaatsumi microbialproductionofhumanmilkoligosaccharides |