Amygdala-centred functional connectivity affects daily cortisol concentrations: a putative link with anxiety
Abstract The amygdala plays a critical role in emotion. Its functional coupling with the hippocampus and ventromedial prefrontal cortex extending to a portion of the anterior cingulate cortex (ACC) is implicated in anxiogenesis and hypothalamic-pituitary-adrenal (HPA) system regulation. However, it...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-08918-7 |
| _version_ | 1818749369240780800 |
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| author | Yuko Hakamata Shotaro Komi Yoshiya Moriguchi Shuhei Izawa Yuki Motomura Eisuke Sato Shinya Mizukami Yoshiharu Kim Takashi Hanakawa Yusuke Inoue Hirokuni Tagaya |
| author_facet | Yuko Hakamata Shotaro Komi Yoshiya Moriguchi Shuhei Izawa Yuki Motomura Eisuke Sato Shinya Mizukami Yoshiharu Kim Takashi Hanakawa Yusuke Inoue Hirokuni Tagaya |
| author_sort | Yuko Hakamata |
| collection | DOAJ |
| description | Abstract The amygdala plays a critical role in emotion. Its functional coupling with the hippocampus and ventromedial prefrontal cortex extending to a portion of the anterior cingulate cortex (ACC) is implicated in anxiogenesis and hypothalamic-pituitary-adrenal (HPA) system regulation. However, it remains unclear how amygdala-centred functional connectivity (FC) affects anxiety and cortisol concentrations in everyday life. Here, we investigate the relationship between daily cortisol concentrations (dCOR) and amygdala-centred FC during emotional processing in forty-one healthy humans. FC analyses revealed that higher dCOR predicted strengthened amygdala-centred FC with the hippocampus and cerebellum, but inhibited FC with the supramarginal gyrus and a perigenual part of the ACC (pgACC) when processing fearful faces (vs. neutral faces). Notably, the strength of amygdala-hippocampus FC mediated the positive relationship between cortisol and anxiety, specifically when the effect of amygdala-pgACC FC, a presumptive neural indicator of emotional control, was taken into account. Individuals with diminished connectivity between the amygdala and pgACC during fear-related processing might be more vulnerable to anxiogenesis as it pertains to greater circulating cortisol levels in everyday life. Individual functional patterns of amygdala-hippocampal-pgACC connectivity might provide a key to understand the complicate link between cortisol and anxiety-related behaviors. |
| first_indexed | 2024-12-18T04:02:41Z |
| format | Article |
| id | doaj.art-1d3afdc8420e4db4a29d9c05c4b876f2 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-18T04:02:41Z |
| publishDate | 2017-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-1d3afdc8420e4db4a29d9c05c4b876f22022-12-21T21:21:39ZengNature PortfolioScientific Reports2045-23222017-08-017111110.1038/s41598-017-08918-7Amygdala-centred functional connectivity affects daily cortisol concentrations: a putative link with anxietyYuko Hakamata0Shotaro Komi1Yoshiya Moriguchi2Shuhei Izawa3Yuki Motomura4Eisuke Sato5Shinya Mizukami6Yoshiharu Kim7Takashi Hanakawa8Yusuke Inoue9Hirokuni Tagaya10Department of Adult Mental Health, National Institute of Mental Health, National Center of Neurology and PsychiatryDepartment of Radiology, Kitasato University HospitalIntegrative Brain Imaging Center, National Center of Neurology and PsychiatryOccupational Stress Research Group, National Institute of Occupational Safety and HealthDepartment of Psychophysiology, National Institute of Mental Health, National Center of Neurology and PsychiatryDepartment of Medical Radiological Technology, Kyorin University School of Health SciencesDepartment of Clinical Engineering, Kitasato University School of Allied Health SciencesDepartment of Adult Mental Health, National Institute of Mental Health, National Center of Neurology and PsychiatryIntegrative Brain Imaging Center, National Center of Neurology and PsychiatryDepartment of Diagnostic Radiology, Kitasato University School of MedicineDepartment of Health Sciences, Kitasato University School of Allied Health SciencesAbstract The amygdala plays a critical role in emotion. Its functional coupling with the hippocampus and ventromedial prefrontal cortex extending to a portion of the anterior cingulate cortex (ACC) is implicated in anxiogenesis and hypothalamic-pituitary-adrenal (HPA) system regulation. However, it remains unclear how amygdala-centred functional connectivity (FC) affects anxiety and cortisol concentrations in everyday life. Here, we investigate the relationship between daily cortisol concentrations (dCOR) and amygdala-centred FC during emotional processing in forty-one healthy humans. FC analyses revealed that higher dCOR predicted strengthened amygdala-centred FC with the hippocampus and cerebellum, but inhibited FC with the supramarginal gyrus and a perigenual part of the ACC (pgACC) when processing fearful faces (vs. neutral faces). Notably, the strength of amygdala-hippocampus FC mediated the positive relationship between cortisol and anxiety, specifically when the effect of amygdala-pgACC FC, a presumptive neural indicator of emotional control, was taken into account. Individuals with diminished connectivity between the amygdala and pgACC during fear-related processing might be more vulnerable to anxiogenesis as it pertains to greater circulating cortisol levels in everyday life. Individual functional patterns of amygdala-hippocampal-pgACC connectivity might provide a key to understand the complicate link between cortisol and anxiety-related behaviors.https://doi.org/10.1038/s41598-017-08918-7 |
| spellingShingle | Yuko Hakamata Shotaro Komi Yoshiya Moriguchi Shuhei Izawa Yuki Motomura Eisuke Sato Shinya Mizukami Yoshiharu Kim Takashi Hanakawa Yusuke Inoue Hirokuni Tagaya Amygdala-centred functional connectivity affects daily cortisol concentrations: a putative link with anxiety Scientific Reports |
| title | Amygdala-centred functional connectivity affects daily cortisol concentrations: a putative link with anxiety |
| title_full | Amygdala-centred functional connectivity affects daily cortisol concentrations: a putative link with anxiety |
| title_fullStr | Amygdala-centred functional connectivity affects daily cortisol concentrations: a putative link with anxiety |
| title_full_unstemmed | Amygdala-centred functional connectivity affects daily cortisol concentrations: a putative link with anxiety |
| title_short | Amygdala-centred functional connectivity affects daily cortisol concentrations: a putative link with anxiety |
| title_sort | amygdala centred functional connectivity affects daily cortisol concentrations a putative link with anxiety |
| url | https://doi.org/10.1038/s41598-017-08918-7 |
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